Analysis of mutations within the 5′ untranslated region, interferon sensitivity region, and PePHD region as a function of response to interferon therapy in hepatitis C virus-infected patients in India

Journal of Clinical Microbiology

Volumn 44, Issue 3, 2006, Pages 709-715

  Gupta, Romi ^a   Subramani, Murugan ^a   Khaja, Mohammed N ^b   Madhavi, Chandra ^b   Roy, Swagata ^a   Habibullah, Chittoor M ^b   Das, Saumitra ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b DECCAN COLLEGE OF MEDICAL SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2A INTERFERON; ENVELOPE PROTEIN; GLYCOPROTEIN E2; INITIATION FACTOR 2; INTERFERON; PROTEIN KINASE R; PROTEIN PEPHD; RIBAVIRIN; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ADULT; ARTICLE; CLINICAL ARTICLE; FEMALE; GENE MUTATION; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; INDIA; INTERFERON SENSITIVITY REGION; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SPECIES DIFFERENCE; VIRUS GENE; VIRUS LOAD;

5' UNTRANSLATED REGIONS; ADULT; AMINO ACID SEQUENCE; DRUG RESISTANCE, VIRAL; FEMALE; GENES, VIRAL; GENOTYPE; HEPACIVIRUS; HEPATITIS C; HUMANS; INDIA; INTERFERONS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; PHYLOGENY; SEQUENCE HOMOLOGY, AMINO ACID; VIRAL ENVELOPE PROTEINS; VIRAL NONSTRUCTURAL PROTEINS;

EUKARYOTA; HEPATITIS C VIRUS;

EID: 33644917182     PISSN: 00951137     EISSN: None     Source Type: Journal    
DOI: 10.1128/JCM.44.3.709-715.2006     Document Type: Article

References (26)

1. Bhattacharyya, S., K. Mapa, S. Prabhavathi, S. R. Sudhamani, P. K. Menon, K. P. John, C. Shivaram, S. Amarnath, and S. Das. 2004. Phylogenetic conservation of the stem-loop III structure of the 5′ untranslated region of hepatitis C virus RNA among natural variants in samples collected from Southern India. Arch. Virol. 149:1015-1026.
2. Catherine, G., M. Lambele, A. Moreau, P. Veillon, F. Lunel, and A. Goudeau. 2005. Mutations with in the hepatitis C virus genotype 1b E2-PePHD domain do not correlate with treatment outcome. J. Clin. Microbiol. 43:750-754.
3. Chayama, K., F. Suzuki, A. Tsubota, M. Kobayashi, Y. Arase, S. Saitoh, Y. Suzuki, N. Murashima, K. Ikeda, N. Takahashi, M. Kinoshita, and H. Kumada. 2000. Association of amino acid sequence in the PKR-eIF2 phosphorylation homology domain and response to interferon therapy. Hepatology 32:1138-1144.
4. Choo, Q. L., G. Kuo, A. J. Weiner, L. R. Overby, D. W. Bradley, and M. Houghton. 1989. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244:359-362.
5. Chowdhury, A., A. Santra, S. Chaudhuri, G. K. Dhali, S. Chaudhuri, S. G. Maity, T. N. Naik, S. K. Bhattacharya, and D. N. Mazumder. 2003. Hepatitis C virus infection in the general population: a community-based study in West Bengal, India. Hepatology 37:802-809.
6. Francesco, D. R. 1999. Molecular virology of the hepatitis C virus. J. Hepatol. 31:47-53.
7. Fried, M. W., and S. J. Hadziyannis. 2004. Treatment of chronic hepatitis C infection with peginterferons plus ribavirin. Semin. Liver Dis. 24:47-54.
8. Gale, M. J., C. M. Blakely, B. Kwieciszewski, S. L. Tan, M. Dosset, N. M. Tang, M. J. Korth, S. J. Polyak, D. R. Gretch, and M. G. Katze. 1998. Control of PKR protein kinase by hepatitis C virus nonstructural protein 5A: molecular mechanisms of kinase regulation. Mol. Cell. Biol. 18:5208-5218.
9. Hagedorn, C. H., and C. M. Rice. 2000. Hepatitis C virus. Curr. Top. Microbiol. Immunol. 242:85-111.
10. Hazari, S., S. K. Panda, S. D. Gupta, Y. Batra, R. Singh, and S. K. Acharya. 2004. Treatment of hepatitis C virus infection in patients of northern India. J. Gastroenterol. Hepatol. 19:1058-1065.
11. Hofgärtner, W. T., S. J. Polyak, D. G. Sullivan, R. L. Carithers, Jr., and D. R. Gretch. 1997. Mutations in the NS5A gene of hepatitis C virus in North American patients infected with HCV genotype 1a or 1b. J. Med. Virol. 53:118-126.
12. Lake-Bakaar, G. 2003. Current and future therapy for chronic hepatitis C virus liver disease. Curr. Drug Targets Infect. Disord. 3:247-253.
13. Lole, K. S., J. A. Jha, S. P. Shrotri, B. N. Tandon, V. G. Prasad, and V. A. Arankalle. 2003. Comparison of hepatitis C virus genotyping by 5′ noncoding region- and core-based reverse transcriptase PCR assay with sequencing and use of the assay for determining subtype distribution in India. J. Clin. Microbiol. 41:5240-5244.
14. Nakano, I., Y. Fukuda, Y. Katano, S. Nakano, T. Kumada, and T. Hayakawa. 1999. Why is the interferon sensitivity-determining region (ISDR) system useful in Japan? J. Hepatol. 30:1014-1022.
15. Nousbaum, J. B. 1998. Genomic subtypes of hepatitis C virus: epidemiology, diagnosis and clinical consequences. Bull. Soc. Pathol. Exot. 91:29-33.
16. Panigrahi, A. K., J. Roca, S. K. Aacharya, S. Jameel, and S. K. Panda. 1996. Genotype determination of hepatitis C virus from northern India: identification of a new subtype. J. Med. Virol. 48:191-198.
17. Pawlotsky, J. M. 2003. The nature of interferon-alpha resistance in hepatitis C virus infection. Curr. Opin. Infect. Dis. 16:587-592.
18. Sarrazin, C., I. Kornetzky, B., Ruster, J. H. Lee, B. Kronenberger, K. Bruch, W. K. Roth, and S. Zeuzem. 2000. Mutations within the E2 and NS5A protein in patients infected with hepatitis C virus type 3a and correlation with treatment response. Hepatology 31:1360-1361.
19. Simmonds, P. 2004. Genetic diversity and evolution of hepatitis C virus - 15 years on. J. Gen. Virol. 85:3173-3188.
20. Singh, S., V. Malhotra, and S. K. Sarin. 2004. Distribution of hepatitis C virus genotypes in patients with chronic hepatitis C infection in India. Indian J. Med. Res. 119:145-148.
21. Sloer, M., M. Pellerin, C. E. Malnou, D. Dhumeaux, K. M. Kean, and J. M. Pawlotsky. 2002. Quasispecies heterogeneity and constraints on the evolution of the 5′ noncoding region of hepatitis C virus (HCV): relationship with HCV resistance to interferon α therapy. Virology 298:160-173.
22. Suzuki, R., T. Suzuki, K. Ishii, Y. Matsuura, and T. Miyamura. 1999. Processing and functions of hepatitis C virus proteins. Intervirology 42:145-152.
23. Taylor, D. R., S. T. Shi, P. R. Romano, G. N. Barber, and M. M. C. Lai. 1999. Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein. Science 285:107-110.
24. Valliammai, T., S. P. Thyagarajan, A. J. Zuckerman, and T. J. Harrison. 1995. Diversity of genotypes of hepatitis C virus in southern India. J. Gen. Virol. 76:711-716.
25. Wolf, P. H., S. Zeuzem, and C. Sarrazin. 2005. Hepatitis C virus resistance mechanisms to interferon α-based antiviral therapy. J. Clin. Virol. 32:86-91.
26. Zeuzem, S., M. Diago, E. Gane, K. R. Reddy, P. Pockros, D. Prati, M. Shiffman, P. Farci, N. Gitlin, C. B. O'Brien, F. Lamour, P. Lardelli, and the PEGASYS Study NR16071 Investigator Group. 2005. Peginterferon alfa-2a (40 kilodaltons) and ribavirin in patients with chronic hepatitis C and normal aminotransferase levels. Gastroenterology 128:1531-1532.