The possible role of myostatin in skeletal muscle atrophy and cachexia

Scandinavian Journal of Medicine and Science in Sports

Volumn 16, Issue 2, 2006, Pages 74-82

  Jespersen, J ^a,b   Kjaer, M ^a   Schjerling, P ^b  

^a BISPEBJERG HOSPITAL   (Denmark)

^b Rigshospitalet   (Denmark)

Author keywords

Critical illness; GDF 8; Muscle breakdown; Sarcopenia

Indexed keywords

MYOSTATIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; CACHEXIA; HUMAN; METABOLISM; MUSCLE ATROPHY; PATHOLOGY; REVIEW; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

ANIMALS; CACHEXIA; HUMANS; MUSCLE, SKELETAL; MUSCULAR ATROPHY; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 33644881099     PISSN: 09057188     EISSN: 16000838     Source Type: Journal    
DOI: 10.1111/j.1600-0838.2005.00498.x     Document Type: Review

References (72)

1. Anker SD Negassa A Coats AJ Afzal R Poole-Wilson PA Cohn JN Yusuf S. Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors an observational study Lancet 2003 361 1077 1083
2. Anker SD Ponikowski P Varney S Chua TP Clark AL Webb-Peploe KM Harrington D Kox WJ Poole-Wilson PA Coats AJ. Wasting as independent risk factor for mortality in chronic heart failure Lancet 1997 349 1050 1053
3. Anker SD Sharma R. The syndrome of cardiac cachexia Int J Cardiol 2002 85 51 66
4. Argiles JM Busquets S Lopez-Soriano FJ. Cytokines in the pathogenesis of cancer cachexia Curr Opin Clin Nutr Metab Care 2003 6 401 406
5. Bogdanovich S Krag TO Barton ER Morris LD Whittemore LA Ahima RS Khurana TS. Functional improvement of dystrophic muscle by myostatin blockade Nature 2002 420 418 421
6. Bogdanovich S Perkins KJ Krag TO Whittemore LA Khurana TS. Myostatin propeptide-mediated amelioration of dystrophic pathophysiology FASEB J 2005 19 543 549
7. Carlson CJ Booth FW Gordon SE. Skeletal muscle myostatin mrna expression is fiber-type specific and increases during hindlimb unloading Am J Physiol 1999 277 R601 R606
8. Charge SB Rudnicki MA. Cellular and molecular regulation of muscle regeneration Physiol Rev 2004 84 209 238
9. Dahele M Fearon KC. Research methodology cancer cachexia syndrome Palliat Med 2004 18 409 417
10. Dasarathy S Dodig M Muc SM Kalhan SC McCullough AJ. Skeletal muscle atrophy is associated with an increased expression of myostatin and impaired satellite cell function in the portacaval anastamosis rat Am J Physiol Gastrointest Liver Physiol 2004 287 G1124 G1130
11. Engelman DT Adams DH Byrne JG Aranki SF Collins Jr. JJ Couper GS Allred EN Cohn LH Rizzo RJ. Impact of body mass index and albumin on morbidity and mortality after cardiac surgery J Thorac Cardiovasc Surg 1999 118 866 873
12. Ferrell RE Conte V Lawrence EC Roth SM Hagberg JM Hurley BF. Frequent sequence variation in the human myostatin (GDF8) gene as a marker for analysis of muscle-related phenotypes Genomics 1999 62 203 207
13. Frost RA Lang CH. Skeletal muscle cytokines regulation by pathogen-associated molecules and catabolic hormones Curr Opin Clin Nutr Metab Care 2005 8 255 263
14. Glass DJ. Molecular mechanisms modulating muscle mass Trends Mol Med 2003 9 344 350
15. Glass DJ. Skeletal muscle hypertrophy and atrophy signaling pathways Int J Biochem Cell Biol 2005 37 1974 1984
16. Gonzalez-Cadavid NF Bhasin S. Role of myostatin in metabolism Curr Opin Clin Nutr Metab Care 2004 7 451 457
17. Gonzalez-Cadavid NF Taylor WE Yarasheski K Sinha-Hikim I Ma K Ezzat S Shen R Lalani R Asa S Mamita M Nair G Arver S Bhasin S. Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting Proc Natl Acad Sci USA 1998 95 14938 14943
18. Grobet L Martin LJ Poncelet D Pirottin D Brouwers B Riquet J Schoeberlein A Dunner S Menissier F Massabanda J Fries R Hanset R Georges M. A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle Nat Genet 1997 17 71 74
19. Grobet L Pirottin D Farnir F Poncelet D Royo LJ Brouwers B Christians E Desmecht D Coignoul F Kahn R Georges M. Modulating skeletal muscle mass by postnatal, muscle-specific inactivation of the myostatin gene Genesis 2003 35 227 238
20. Guttridge DC. Signaling pathways weigh in on decisions to make or break skeletal muscle Curr Opin Clin Nutr Metab Care 2004 7 443 450
21. Haddad F Roy RR Zhong H Edgerton VR Baldwin KM. Atrophy responses to muscle inactivity. II. Molecular markers of protein deficits J Appl Physiol 2003 95 791 802
22. Hanset R Michaux C Dessy-Doize C Burtonboy G. Studies on the 7th rib cut in double-muscled and conventional cattle. Anatomical, histological and biochemical aspects In King J Menissier F eds. Muscle hypertrophy of genetic origin and its use to improve beef production Martinus Nijhoff The Hague 1982 341 349
23. Hasselgren PO Fischer JE. Muscle cachexia current concepts of intracellular mechanisms and molecular regulation Ann Surg 2001 233 9 17
24. Hill JJ Davies MV Pearson AA Wang JH Hewick RM Wolfman NM Qiu Y. The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum J Biol Chem 2002 277 40735 40741
25. Hill JJ Qiu Y Hewick RM Wolfman NM. Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1 a novel protein with protease inhibitor and follistatin domains Mol Endocrinol 2003 17 1144 1154
26. Hoffman EP Nader GA. Balancing muscle hypertrophy and atrophy Nat Med 2004 10 584 585
27. Huet C Li ZF Liu HZ Black RA Galliano MF Engvall E. Skeletal muscle cell hypertrophy induced by inhibitors of metalloproteases; myostatin as a potential mediator Am J Physiol Cell Physiol 2001 281 C1624 C1634
28. Huygens W Thomis MA Peeters MW Aerssens J Janssen R Vlietinck RF Beunen G. Linkage of myostatin pathway genes with knee strength in humans Physiol Genomics 2004 17 264 270
29. Ivey FM Roth SM Ferrell RE Tracy BL Lemmer JT Hurlbut DE Martel GF Siegel EL Fozard JL Jeffrey ME Fleg JL Hurley BF. Effects of age, gender, and myostatin genotype on the hypertrophic response to heavy resistance strength training J Gerontol A Biol Sci Med Sci 2000 55 M641 M648
30. Jackman RW Kandarian SC. The molecular basis of skeletal muscle atrophy Am J Physiol Cell Physiol 2004 287 C834 C843
31. Jagoe RT Lecker SH Gomes M Goldberg AL. Patterns of gene expression in atrophying skeletal muscles response to food deprivation FASEB J 2002 16 1697 1712
32. Kadi F Schjerling P Andersen LL Charifi N Madsen JL Christensen LR Andersen JL. The effects of heavy resistance training and detraining on satellite cells in human skeletal muscles J Physiol 2004 558 1005 1012
33. Kadi F Thornell LE. Concomitant increases in myonuclear and satellite cell content in female trapezius muscle following strength training Histochem Cell Biol 2000 113 99 103
34. Kambadur R Sharma M Smith TP Bass JJ. Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle Genome Res 1997 7 910 916
35. Kotler DP. Cachexia Ann Intern Med 2000 133 622 634
36. Kotler DP Tierney AR Wang J Pierson Jr. RN. Magnitude of body-cell-mass depletion and the timing of death from wasting in AIDS Am J Clin Nutr 1989 50 444 447
37. Lecker SH Jagoe RT Gilbert A Gomes M Baracos V Bailey J Price SR Mitch WE Goldberg AL. Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression FASEB J 2004 18 39 51
38. Lee SJ. Regulation of muscle mass by myostatin Annu Rev Cell Dev Biol 2004 20 61 86
39. Lee SJ McPherron AC. Regulation of myostatin activity and muscle growth Proc Natl Acad Sci USA 2001 98 9306 9311
40. Lodish H Berk A Matsudaira P Kaiser CA Krieger M Scott MP Zipursky L Darnell J. Molecular cell biology New York W.H. Freeman and Company 2003
41. MacDonald N Easson AM Mazurak VC Dunn GP Baracos VE. Understanding and managing cancer cachexia J Am Coll Surg 2003 197 143 161
42. McCroskery S Thomas M Maxwell L Sharma M Kambadur R. Myostatin negatively regulates satellite cell activation and self-renewal J Cell Biol 2003 162 1135 1147
43. McMahon CD Popovic L Oldham JM Jeanplong F Smith HK Kambadur R Sharma M Maxwell L Bass JJ. Myostatin-deficient mice lose more skeletal muscle mass than wild-type controls during hindlimb suspension Am J Physiol Endocrinol Metab 2003 285 E82 E87
44. McPherron AC Lawler AM Lee SJ. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member Nature 1997 387 83 90
45. McPherron AC Lee SJ. Double muscling in cattle due to mutations in the myostatin gene Proc Natl Acad Sci USA 1997 94 12457 12461
46. Plank LD Hill GL. Sequential metabolic changes following induction of systemic inflammatory response in patients with severe sepsis or major blunt trauma World J Surg 2000a 24 630 638
47. Plank LD Hill GL. Similarity of changes in body composition in intensive care patients following severe sepsis or major blunt injury Ann N Y Acad Sci 2000b 904 592 602
48. Potapov EV Loebe M Anker S Stein J Bondy S Nasseri BA Sodian RR Hausmann H Hetzer R. Impact of body mass index on outcome in patients after coronary artery bypass grafting with and without valve surgery Eur Heart J 2003 24 1933 1941
49. Reardon KA Davis J Kapsa RM Choong P Byrne E. Myostatin, insulin-like growth factor-1, and leukemia inhibitory factor mrnas are upregulated in chronic human disuse muscle atrophy Muscle Nerve 2001 24 893 899
50. Rebbapragada A Benchabane H Wrana JL Celeste AJ Attisano L. Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis Mol Cell Biol 2003 23 7230 7242
51. Rennie MJ Wackerhage H Spangenburg EE Booth FW. Control of the size of the human muscle mass Annu Rev Physiol 2004 66 799 828
52. Roth SM Martel GF Ferrell RE Metter EJ Hurley BF Rogers MA. Myostatin gene expression is reduced in humans with heavy-resistance strength training a brief communication Exp Biol Med (Maywood) 2003 228 706 709
53. Roubenoff R. Origins and clinical relevance of sarcopenia Can J Appl Physiol 2001 26 78 89
54. Sartorelli V Fulco M. Molecular and cellular determinants of skeletal muscle atrophy and hypertrophy Sci STKE 2004 re11
55. Schols AM Broekhuizen R Weling-Scheepers CA Wouters EF. Body composition and mortality in chronic obstructive pulmonary disease Am J Clin Nutr 2005 82 53 59
56. Schuelke M Wagner KR Stolz LE Hubner C Riebel T Komen W Braun T. Tobin JF Lee SJ. Myostatin mutation associated with gross muscle hypertrophy in a child N Engl J Med 2004 350 2682 2688
57. Seibert MJ Xue QL Fried LP Walston JD. Polymorphic variation in the human myostatin (GDF-8) gene and association with strength measures in the women's health and aging study II cohort J Am Geriatr Soc 2001 49 1093 1096
58. Siriett V Nicholas G Berry C Watson T Hennebry A Thomas M Ling N Sharma M Kambadur R. Myostatin negatively regulates the expression of the steroid receptor co-factor ARA70 J Cell Physiol 2005 in press
59. Tang AM Forrester J Spiegelman D Knox TA Tchetgen E Gorbach SL. Weight loss and survival in HIV-positive patients in the era of highly active antiretroviral therapy J Acquir Immune Defic Syndr 2002 31 230 236
60. Taylor WE Bhasin S Artaza J Byhower F Azam M Willard Jr. DH Kull Jr. FC Gonzalez-Cadavid N. Myostatin inhibits cell proliferation and protein synthesis in C2C12 muscle cells Am J Physiol Endocrinol Metab 2001 280 E221 E228
61. Thies RS Chen T Davies MV Tomkinson KN Pearson AA Shakey QA Wolfman NM. GDF-8 propeptide binds to GDF-8 and antagonizes biological activity by inhibiting GDF-8 receptor binding Growth Factors 2001 18 251 259
62. Tisdale MJ. Cachexia in cancer patients Nat Rev Cancer 2002 2 862 871
63. Wagner KR Liu X Chang X Allen RE. Muscle regeneration in the prolonged absence of myostatin Proc Natl Acad Sci USA 2005 102 2519 2524
64. Wehling M Cai B Tidball JG. Modulation of myostatin expression during modified muscle use FASEB J 2000 14 103 110
65. Whittemore LA Song K Li X Aghajanian J Davies M Girgenrath S Hill JJ Jalenak M Kelley P Knight A Maylor R O'Hara D Pearson A Quazi A Ryerson S Tan XY Tomkinson KN Veldman GM Widom A Wright JF Wudyka S Zhao L Wolfman NM. Inhibition of myostatin in adult mice increases skeletal muscle mass and strength Biochem Biophys Res Commun 2003 300 965 971
66. Wolfman NM McPherron AC Pappano WN Davies MV Song K Tomkinson KN Wright JF Zhao L Sebald SM Greenspan DS Lee SJ. Activation of latent myostatin by the BMP-1%tolloid family of metalloproteinases Proc Natl Acad Sci USA 2003 100 15842 15846
67. Yang W Zhang Y Ma G Zhao X Chen Y Zhu D. Identification of gene expression modifications in myostatin-stimulated myoblasts Biochem Biophys Res Commun 2005 326 660 666
68. Yarasheski KE Bhasin S Sinha-Hikim I Pak-Loduca J Gonzalez-Cadavid NF. Serum myostatin-immunoreactive protein is increased in 60-92 year old women and men with muscle wasting J Nutr Health Aging 2002 6 343 348
69. Zachwieja JJ Smith SR Sinha-Hikim I Gonzalez-Cadavid N Bhasin S. Plasma myostatin-immunoreactive protein is increased after prolonged bed rest with low-dose T3 administration J Gravit Physiol 1999 6 11 15
70. Zhu X Hadhazy M Wehling M Tidball JG McNally EM. Dominant negative myostatin produces hypertrophy without hyperplasia in muscle FEBS Lett 2000 474 71 75
71. Zhu X Topouzis S Liang LF Stotish RL. Myostatin signaling through Smad2, Smad3 and Smad4 is regulated by the inhibitory Smad7 by a negative feedback mechanism Cytokine 2004 26 262 272
72. Zimmers TA Davies MV Koniaris LG Haynes P Esquela AF Tomkinson KN McPherron AC Wolfman NM Lee SJ. Induction of cachexia in mice by systemically administered myostatin Science 2002 296 1486 1488