Molecular analysis of PDGFRα/β genes in core binding factor leukemia with eosinophilia

European Journal of Haematology

Volumn 76, Issue 1, 2006, Pages 18-22

  Monma, Fumihiko ^a   Nishii, Kazuhiro ^a   Lorenzo, Felipe V ^a   Usui, Eiji ^a   Ueda, Yuichiro ^a   Watanabe, Yasuyuki ^b   Kawakami, Keiki ^b   Oka, Koji ^c   Mitani, Hidetsugu ^d   Sekine, Takao ^d   Tamaki, Shigehisa ^e   Mizutani, Minoru ^e   Yagasaki, Fumiharu ^f   Doki, Noriko ^g   Miyawaki, Syuichi ^g   Katayama, Naoyuki ^a   Shiku, Hiroshi ^a  

^a MIE UNIVERSITY   (Japan)

^b SUZUKA GENERAL HOSPITAL   (Japan)

^c Suzuka Kaisei General Hospital   (Japan)

^d Matsusaka General Hospital   (Japan)

^e ISE RED CROSS HOSPITAL   (Japan)

^f SAITAMA MEDICAL UNIVERSITY   (Japan)

^g Maebashi North Hospital   (Japan)

Author keywords

Acute myeloid leukemia; Eosinophilia; inv(16); Mutation; PDGFR; t(8; 21)

Indexed keywords

COMPLEMENTARY DNA; CORE BINDING FACTOR; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN TYROSINE KINASE; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; FIP1L1 PDGFRA FUSION PROTEIN, HUMAN; FIP1L1-PDGFRA FUSION PROTEIN, HUMAN; ONCOPROTEIN; TRANSCRIPTION FACTOR RUNX2;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DNA SEQUENCE; EOSINOPHILIA; FEMALE; FUSION GENE; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENETIC SCREENING; HUMAN; HUMAN CELL; LEUKEMIA; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE; ACUTE GRANULOCYTIC LEUKEMIA; CASE CONTROL STUDY; GENE EXPRESSION REGULATION; GENETIC POLYMORPHISM; GENETICS; MIDDLE AGED; PATHOLOGY; POINT MUTATION; PROTEIN TERTIARY STRUCTURE; SYNDROME;

ADULT; AGED; CASE-CONTROL STUDIES; CORE BINDING FACTOR ALPHA 1 SUBUNIT; CORE BINDING FACTORS; DNA MUTATIONAL ANALYSIS; DNA, COMPLEMENTARY; EOSINOPHILIA; FEMALE; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; LEUKEMIA, MYELOCYTIC, ACUTE; MALE; MIDDLE AGED; MRNA CLEAVAGE AND POLYADENYLATION FACTORS; ONCOGENE PROTEINS, FUSION; POINT MUTATION; POLYMORPHISM, GENETIC; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; SYNDROME;

EID: 33644874825     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2005.00543.x     Document Type: Article

References (25)

1. L e B eau MM L arson RA B itter MA et al. Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. A unique cytogenetic-clinicopathological association N Engl J Med 1983 309 630 636
2. E ma H K itano K S uda T et al. In vitro differentiation of leukemic cells to eosinophils in the presence of interleukin-5 in two cases of acute myeloid leukemia with the translocation (8;21)(q22;q22) Blood 1990 75 350 356
3. B aumann MA P aul CC G race MJ Effects of interleukin-5 on acute myeloid leukemias Am J Hematol 1992 39 269 274
4. N ishii K K ita K N adim M et al. Expression of interleukin-5 receptors on acute myeloid leukaemia cells: association with immunophenotype and karyotype Br J Haematol 1995 91 169 172
5. N ishii K U sui E K atayama N et al. Characteristics of t(8;21) acute myeloid leukemia (AML) with additional chromosomal abnormality: concomitant trisomy 4 may constitute a distinctive subtype of t(8;21) AML Leukemia 2003 17 731 737
6. B ain BJ Eosinophilic leukaemias and the idiopathic hypereosinophilic syndrome Br J Haematol 1996 95 2 9
7. R oche -L estienne C L epers S S oenen -C ornu V et al. Molecular characterization of the idiopathic hypereosinophilic syndrome (HES) in 35 French patients with normal conventional cytogenetics Leukemia 2005 19 792 798
8. H aferlach T W inkemann M L offler H et al. The abnormal eosinophils are part of the leukemic cell population in acute myelomonocytic leukemia with abnormal eosinophils (AML M4Eo) and carry the pericentric inversion 16: a combination of May-Grunwald-Giemsa staining and fluorescence in situ hybridization Blood 1996 87 2459 2463
9. van L om K H agemeijer A V andekerckhove F et al. Clonality analysis of hematopoietic cell lineages in acute myeloid leukemia and translocation (8;21): only myeloid cells are part of the malignant clone Leukemia 1997 11 202 205
10. C ools J D e A ngelo DJ G otlib J et al. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome N Engl J Med 2003 348 1201 1214
11. G otlib J C ools J M alone JM III. et al. The FIP1L1-PDGFRalpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management Blood 2004 103 2879 2891
12. A pperley JF G ardembas M M elo JV et al. Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta N Engl J Med 2002 347 481 487
13. Y arden Y K uang WJ Y ang -F eng T et al. Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand Embo J 1987 6 3341 3351
14. P ietras K R ubin K S joblom T et al. Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy Cancer Res 2002 62 5476 5484
15. C astilla LH G arrett L A dya N et al. The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia Nat Genet 1999 23 144 146
16. G illiland DG Molecular genetics of human leukemias: new insights into therapy Semin Hematol 2002 39 6 11
17. G risolano JL O'N eal J C ain J et al. An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice Proc Natl Acad Sci USA 2003 100 9506 9511
18. R eilly JT Pathogenesis of acute myeloid leukaemia and inv(16)(p13;q22): a paradigm for understanding leukaemogenesis Br J Haematol 2005 128 18 34
19. N ishii K K ita K M iwa H et al. Expression of B cell-associated transcription factors in B-cell precursor acute lymphoblastic leukemia cells: association with PU.1 expression, phenotype, and immunogenotype Int J Hematol 2000 71 372 378
20. P ardanani A R eeder T L i CY et al. Eosinophils are derived from the neoplastic clone in patients with systemic mastocytosis and eosinophilia Leuk Res 2003 27 883 885
21. W ilkinson K V elloso ER L opes LF et al. Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib Blood 2003 102 4187 4190
22. H einrich MC C orless CL D uensing A et al. PDGFRA activating mutations in gastrointestinal stromal tumors Science 2003 299 708 710
23. H irota S O hashi A N ishida T et al. Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors Gastroenterology 2003 125 660 667
24. S anderson CJ Interleukin-5, eosinophils, and disease Blood 1992 79 3101 3109
25. R hoades KL H etherington CJ H arakawa N et al. Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model Blood 2000 96 2108 2115