Oxidative stress response in normal and antioxidant supplemented rats to a downhill run: Changes in blood and skeletal muscles

Canadian Journal of Applied Physiology

Volumn 30, Issue 6, 2005, Pages 677-689

  You, Tongjian ^a   Goldfarb, Allan H ^b   Bloomer, Richard J ^c   Nguyen, Linh ^b   Sha, Xin ^d   McKenzie, Michael J ^b  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^c UNIVERSITY OF MEMPHIS   (United States)

^d WAKE FOREST UNIVERSITY   (United States)

Author keywords

Eccentric exercise; Lipid peroxidation; Protein carbonyls

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; GLUTATHIONE; MALONALDEHYDE;

ANIMAL; ANIMAL EXPERIMENT; ARTICLE; BLOOD; DIET SUPPLEMENTATION; HINDLIMB; MALE; METABOLISM; OXIDATIVE STRESS; PHYSIOLOGY; PROTEIN CARBONYLATION; RAT; SKELETAL MUSCLE; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; DIETARY SUPPLEMENTS; GLUTATHIONE; HINDLIMB; MALE; MALONDIALDEHYDE; MUSCLE, SKELETAL; OXIDATIVE STRESS; PHYSICAL CONDITIONING, ANIMAL; PROTEIN CARBONYLATION; RATS; RATS, SPRAGUE-DAWLEY; VITAMIN E;

EID: 33644868447     PISSN: 10667814     EISSN: 15432718     Source Type: Journal    
DOI: 10.1139/h05-148     Document Type: Article

References (28)

1. Alessio, H.M., Goldfarb, A.H., and Cao, G. (1997). Exercise-induced oxidative stress before and after vitamin C supplementation. Int. J. Sport Nutr. 7: 1-9.
2. Anderson, M.E. (1985). Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol. 113: 548-555.
3. Armstrong, R.B. (1984). Mechanisms of exercise-induced delayed onset muscular soreness: A brief review. Med. Sci. Sports Exerc. 16: 529-538.
4. Armstrong, R.B., Ogilvie, R.W., and Schwane, J.A. (1983). Eccentric exercise-induced injury to rat skeletal muscle. J. Appl. Physiol. 54: 80-93.
5. Best, T.M., Fiebig, R., Corr, D.T., Brickson, S., and Ji, L.L. (1999). Free radical activity, antioxidant enzyme, and glutathione changes with muscle stretch injury in rabbits. J. Appl. Physiol. 87: 74-82.
6. Faff, J., and Frankiewicz-Jozko, A. (1997). Effect of ubiquinone on exercise-induced lipid peroxidation in rat tissues. Eur. J. Appl. Physiol. 75: 413-417.
7. Frankiewicz-Jozko, A., Faff, J., and Sieradzan-Gabelska, B. (1996). Changes in concentrations of tissue free radical marker and serum creatine kinase during the post-exercise period in rats. Eur. J. Appl. Physiol. 74: 470-474.
8. Gerard-Monnier, D., Erdelmeier, I., Regnard, K., Moze-Henry, N., Yadan, J.C., and Chaudiere, J. (1998). Reactions of 1-methyl-2-phenylindole with malondialdehyde and 4-hydroxyalkenals. Analytical applications to a colorimetric assay of lipid peroxidation. Chem. Res. Toxicol. 11: 1176-1183.
9. Gohil, K., Packer, L., de Lumen, B., Brooks, G.A., and Terblanche, S.E. (1986). Vitamin E deficiency and vitamin C supplements: Exercise and mitochondrial oxidation. J. Appl. Physiol. 60: 1986-1991.
10. Goldfarb, A.H. (1999). Nutritional antioxidants as therapeutic and preventive modalities in exercise-induced muscle damage. Can. J. Appl. Physiol. 24: 249-266.
11. Goldfarb, A.H., McIntosh, M.K., Boyer, B.T., and Fatouros, J. (1994). Vitamin E effects on indexes of lipid peroxidation in muscle from DHEA-treated and exercised rats. J. Appl. Physiol. 76: 1630-1635.
12. Hartmann, A., Niess, A.M., Grunert-Fuchs, M., Poch, B., and Speit, G. (1995). Vitamin E prevents exercise-induced DNA damage. Mutat. Res. 346: 195-202.
13. Ji, L.L., Fu, R., and Mitchell, E.W. (1992). Glutathione and antioxidant enzymes in skeletal muscle: Effects of fiber type and exercise intensity. J. Appl. Physiol. 73: 1854-1859.
14. Kaikkonen, J., Kosonen, L., Nyyssonen, K., Porkkala-Sarataho, E., Salonen, R., Korpela, H., and Salonen, J.T. (1998). Effect of combined coenzyme Q10 and d-alpha-tocopheryl acetate supplementation on exercise-induced lipid peroxidation and muscular damage: A placebo-controlled double-blind study in marathon runners. Free Radic. Res. 29: 85-92.
15. Kanter, M.M., Nolte, L.A., and Holloszy, J.O. (1993). Effects of an antioxidant vitamin mixture on lipid peroxidation at rest and postexercise. J. Appl. Physiol. 74: 965-969.
16. Lee, J., Goldfarb, A.H., Rescino, M.H., Hegde, S., Patrick, S., and Apperson, K. (2002). Eccentric exercise effect on blood oxidative-stress markers and delayed onset of muscle soreness. Med. Sci. Sports Exerc. 34: 443-448.
17. McIntosh, M.K., Goldfarb, A.H., Curtis, L.N., and Cote, P.S. (1993). Vitamin E alters hepatic antioxidant enzymes in rats treated with dehydroepiandrosterone (DHEA). J. Nutr. 123: 216-224.
18. Meagher, E.A., and FitzGerald, G.A. (2000). Indices of lipid peroxidation in vivo: Strengths and limitations. Free Radic. Biol. Med. 28: 1745-1750.
19. Meydani, M., Evans, W.J., Handelman, G., Biddle, L., Fielding, R.A., Meydani, S.N., Burrill, J., Fiatarone, M.A., Blumberg, J.B., and Cannon, J.G. (1993). Protective effect of vitamin E on exercise-induced oxidative damage in young and older adults. Am. J. Physiol. 264: R992-R998.
20. Reznick, A.Z., and Packer, L. (1994). Oxidative damage to proteins: Spectrophotometric method for carbonyl assay. Methods Enzymol. 233: 357-363.
21. Reznick, A.Z., Witt, E., Motsumoto, M., and Packer, L. (1992). Vitamin E inhibits protein oxidation in skeletal muscle of resting and exercised rats. Biochem. Biophys. Res. Commun. 189: 801-806.
22. Rokitzki, L., Logemann, E., Huber, G., Keck, E., and Keul, J. (1994a). Alpha-tocopherol supplementation in racing cyclists during extreme endurance training. Int. J. Sport Nutr. 4: 253-264.
23. Rokitzki, L., Logemann, E., Sagredos, A.N., Murphy, M., Wetzel-Roth, W., and Keul, J. (1994b). Lipid peroxidation and antioxidative vitamins under extreme endurance stress. Acta. Physiol. Scand. 151:149-158.
24. Sen, C.K., Atalay, M., Agren, J., Laaksonen, D.E., Roy, S., and Hanninen, O. (1997). Fish oil and vitamin E supplementation in oxidative stress at rest and after physical exercise. J. Appl. Physiol. 83: 189-195.
25. Sumida, S., Doi, T., Sakurai, M., Yoshioka, Y., and Okamura, K. (1997). Effect of a single bout of exercise and beta-carotene supplementation on the urinary excretion of 8-hydroxy-deoxyguanosine in humans. Free Radic. Res. 27: 607-618.
26. Thompson, D., Williams, C., Kingsley, M., Nicholas, C.W., Lakomy, H.K., McArdle, F., and Jackson M.J. (2001). Muscle soreness and damage parameters after prolonged intermittent shuttle-running following acute vitamin C supplementation. Int. J. Sports Med. 22: 68-75.
27. Tidball, J.G. (1995). Inflammatory cell response to acute muscle injury. Med. Sci. Sports Exerc. 27: 1022-1032.
28. Warren, J.A., Jenkins, R.R., Packer, L., Witt, E.H., and Armstrong, R.B. (1992). Elevated muscle vitamin E does not attenuate eccentric exercise-induced muscle injury. J. Appl. Physiol. 72: 2168-2175.