Phosphomevalonate kinase: Functional investigation of the recombinant human enzyme

Biochemistry

Volumn 45, Issue 10, 2006, Pages 3235-3242

  Herdendorf, Timothy J ^a   Miziorko, Henry M ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; BACTERIA; BIOSYNTHESIS; ENZYMES; FUNGI; GENETIC ENGINEERING; MUTAGENESIS; STRUCTURAL ANALYSIS; SUBSTRATES;

FORWARD REACTION; FUNCTIONAL INVESTIGATION; HOMOLOGY MODEL; ISOPRENOID; KINETIC CONSTANTS; NUCLEOSIDE; PHOSPHOMEVALONATE KINASE (PMK); RECOMBINANT HUMAN ENZYME; REVERSE REACTION;

PROTEINS;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; HISTIDINE; ISOPRENOID; MEVALONATE 5 DIPHOSPHATE; MEVALONATE 5 PHOSPHATE; MEVALONIC ACID; NUCLEOSIDE MONOPHOSPHATE KINASE; PHOSPHOMEVALONATE KINASE; RECOMBINANT ENZYME; STEROL; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME ISOLATION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; GENETIC CONSERVATION; INVERTEBRATE; MODEL; MUTAGENESIS; PLASMID; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN MOTIF; SEQUENCE ANALYSIS; STEROL SYNTHESIS; WILD TYPE;

AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; HUMANS; KINETICS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHOTRANSFERASES; PHOSPHOTRANSFERASES (PHOSPHATE GROUP ACCEPTOR); RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY;

ANIMALIA; BACTERIA (MICROORGANISMS); FUNGI; INVERTEBRATA;

EID: 33644850796     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi052231u     Document Type: Article

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