Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells

Kidney International

Volumn 69, Issue 6, 2006, Pages 989-995

  Qi, W ^a   Chen, X ^a   Twigg, S ^a,b   Polhill, T S ^a   Gilbert, R E ^c,d   Pollock, C A ^a,e  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^c ST VINCENT S HOSPITAL   (Australia)

^d ST MICHAEL'S HOSPITAL   (Canada)

^e ROYAL NORTH SHORE HOSPITAL   (Australia)

Author keywords

Cortical fibroblasts; CTGF; ECM; Proximal tubular cells; pSmad2; TGF 1

Indexed keywords

ANTIFIBROTIC AGENT; COLLAGEN TYPE 4; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; MESSENGER RNA; SMAD2 PROTEIN; TRANILAST; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; EXTRACELLULAR MATRIX; FIBROBLAST; FIBROGENESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTROPHY; IN VITRO STUDY; KIDNEY CELL; KIDNEY CORTEX; KIDNEY FIBROSIS; KIDNEY TUBULE CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

EID: 33644849416     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5000189     Document Type: Article

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