Potential difference measurements of ocular surface Na+ absorption analyzed using an electrokinetic model

Investigative Ophthalmology and Visual Science

Volumn 47, Issue 1, 2006, Pages 306-316

  Levin, Marc H ^a   Jung, Kyung Kim ^a   Hu, Jie ^a   Verkman, Alan S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; ARGININE; BENZAMIL; GLYCINE; PHLORIZIN; SODIUM CHANNEL; TRANSMEMBRANE CONDUCTANCE REGULATOR; CALCIUM CHANNEL; CHLORIDE; DRUG DERIVATIVE; EPITHELIAL SODIUM CHANNEL; POTASSIUM; SODIUM; SODIUM CHANNEL BLOCKING AGENT;

ANIMAL EXPERIMENT; ARTICLE; CHLORIDE TRANSPORT; CONJUNCTIVA EPITHELIUM; CONTROLLED STUDY; CORNEA EPITHELIUM; MATHEMATICAL MODEL; MOUSE; NONHUMAN; POTENTIAL DIFFERENCE; PRIORITY JOURNAL; SODIUM TRANSPORT; ABSORPTION; ANIMAL; CELL MEMBRANE POTENTIAL; CONJUNCTIVA; CORNEA; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MOUSE; CYTOLOGY; ELECTROPHYSIOLOGY; EPITHELIUM CELL; ION TRANSPORT; METABOLISM; PHYSIOLOGY; THEORETICAL MODEL;

ABSORPTION; AMILORIDE; ANIMALS; CALCIUM CHANNELS; CHLORIDES; CONJUNCTIVA; CORNEA; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ELECTROPHYSIOLOGY; EPITHELIAL CELLS; EPITHELIAL SODIUM CHANNEL; ION TRANSPORT; MEMBRANE POTENTIALS; MICE; MICE, INBRED CFTR; MODELS, THEORETICAL; POTASSIUM; SODIUM; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 33644840740     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.05-1082     Document Type: Article

References (36)

1. Dartt DA. Regulation of mucin and fluid secretion by conjunctival epithelial cells. Prog Retin Eye Res. 2002;21:555-576.
2. Candia OA. Electrolyte and fluid transport across corneal, conjunctival, and lens epithelia. Exp Eye Res. 2004;78:527-535.
3. - and fluid secretion. Am J Physiol. 2001;281: C595-C602.
4. Levin MH, Verkman AS. CFTR-regulated chloride transport at the ocular surface in living mice measured by potential differences. Invest Ophthalmol Vis Sci. 2005;46:1428-1434.
5. Marshall WS, Klyce SD. Cellular and paracellular pathway resistance in the "tight" Cl-secreting epithelium of rabbit cornea. J Membr Biol. 1983;73:275-282.
6. Shi XP, Candia OA. Active sodium and chloride transport across the isolated rabbit conjunctiva. Curr Eye Res. 1995;37:927-935.
7. Midelfart A. The effects of amiloride, ouabain, and osmolality on sodium transport across bovine cornea. Pflugers Arch. 1987;408: 243-248.
8. Chang-Lin JE, Kim KJ, Lee VH. Characterization of active ion transport across primary rabbit corneal epithelial cell layers (RCrECL) cultured at an air-interface. Exp Eye Res. 2005;60:827-836.
9. Mirshahi M, Nicolas C, Mirshahi S, Golestaneh N, d'Hermies F, Agarwal MK. Immunochemical analysis of the sodium channel in rodent and human eye. Exp Eye Res. 1999;69:21-32.
10. + channel. Proc Natl Acad Sci USA. 1999;96:5310-5315.
11. Horisberger JD. ENaC-CFTR interactions: the role of electrical coupling of ion fluxes explored in an epithelial cell model. Pflugers Arch. 2003;445:522-528.
12. Latta R, Clausen C, Moore LC. General method for the derivation and numerical solution of epithelial transport models. J Membr Biol. 1984;82:67-82.
13. Verkman AS, Alpern RJ. Kinetic transport model for cellular regulation of pH and solute concentration in the renal proximal tubule. Biophys J. 1987;51:533-546.
14. Hartmann T, Verkman AS. Model of ion transport regulation in chloride-secreting airway epithelial cells. Biophys J. 1990;58:391-401.
15. Colledge WH, Abella BS, Southern KW, et al. Generation and characterization of a delta F508 cystic fibrosis mouse model. Nat Genet. 1995;10:445-452.
16. Ma T, Thiagarajah JR, Yang H, et al. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest. 2002;110:1651-1658.
17. +-dependent L-arginine transport in the pigmented rabbit conjunctiva. Exp Eye Res. 1997; 65:547-553.
18. +-glucose co-transport in the pigmented rabbit conjunctiva. Curr Eye Res. 1997;16:1050-1105.
19. Knowles M, Gatzy J, Boucher R. Relative ion permeability of normal and cystic fibrosis nasal epithelium. J Clin Invest. 1983;71: 1410-1417.
20. +-glucose cotransporters (SGLT-1). Am J Physiol. 1996;270:G919-G926.
21. Sen DK, Sarin GS. Tear glucose levels in normal people and in diabetic patients. Br J Ophthalmol. 1980;64:693-695.
22. Ozdemir M, Buyukbese MA, Cetinkaya A, Ozdemir G. Risk factors for ocular surface disorders in patients with diabetes mellitus. Diabetes Res Clin Pract. 2003;59:195-199.
23. Shiue MH, Kulkarni AA, Gukasyan HJ, Swisher JB, Kim KJ, Lee VH. Pharmacological modulation of fluid secretion in the pigmented rabbit conjunctiva. Life Sci. 2000;67:PL105-PL111.
24. Puck A, Liappis N, Hildenbrand G. Ion exchange column chromatographic investigation of free amino acids in tears of healthy adults. Ophthalmic Res. 1984;16:284-288.
25. Hosoya KI, Horibe Y, Kim KJ, Lee VH. Carrier-mediated transport of NG-nitro-L-arginine, a nitric oxide synthase inhibitor, in the pigmented rabbit conjunctiva. J Pharmacol Exp Ther. 1998;285: 223-227.
26. Friedman MH. Mathematical modeling of transport in structured tissues: corneal epithelium. Am J Physiol. 1978;234:F215-F224.
27. Klyce SD, Wong RK. Site and mode of adrenaline action on chloride transport across the rabbit corneal epithelium. J Physiol. 1977;226:777-799.
28. Klyce SD. Electrical profiles in the corneal epithelium. J Physiol. 1972;226:407-429.
29. Klyce SD. Transport of Na, Cl, and water by the rabbit corneal epithelium at resting potential. Am J Physiol. 1975;228:1446-1452.
30. Amasheh S, Meiri N, Sitter AH, et al. Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. J Cell Sci. 2002;115:4969-4976.
31. - secretion in nasal epithelia of CF mice. Am J Physiol. 1994;266:C1478-C1483.
32. Salinas DB, Pedemonte N, Muanprasat C, Finkbeiner WF, Nielson DW, Verkman AS. CFTR involvement in nasal potential differences in mice and pigs studied using a thiazolidinone CFTR inhibitor. Am J Physiol. 2004;287:L336-L347.
33. + absorption produces cystic fibrosis-like lung disease in mice. Nat Med. 2004;10:487-493.
34. Nagel G, Barbry P, Chabot H, Brochiero E, Hartung K, Grygorczyk R. CFTR fails to inhibit the epithelial sodium channel ENaC, when expressed in Xenopus laevis oocytes. J Physiol. 2005;564:671-682.
35. Festen CM, Slegers JF, Van Os CH. Intracellular activities of chloride, potassium and sodium in rabbit corneal epithelium. Biochim Biophys Acta. 1983;732:394-404.
36. Reuss L, Reinach P, Weinman SA, Grady TP. Intracellular ion activities and Cl-transport mechanisms in bullfrog corneal epithelium. Am J Physiol. 1983;244:C336-C347.