Assessment of growth hormone (GH) secretion in men with adult-onset GH deficiency compared with that in normal men - A Clinical research center study

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 1, 1996, Pages 84-92

  Baum, Howard B A ^a,d   Biller, Beverly M K ^a   Katznelson, Laurence ^a   Oppenheim, Daniel S ^b   Clemmons, David R ^c   Cannistraro, Kristin Baker ^a   Schoenfeld, David A ^a   Best, Sharon A ^a   Klibanski, Anne ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MAINE MEDICAL CENTER   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d American Philosophical Society   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CLONIDINE; GROWTH HORMONE; GROWTH HORMONE BINDING PROTEIN; INSULIN; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ADULT; ARTICLE; CHEMOLUMINESCENCE; CLINICAL ARTICLE; CONTROLLED STUDY; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HUMAN; IMMUNORADIOMETRIC ASSAY; INTRAVENOUS DRUG ADMINISTRATION; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROVOCATION TEST; PULSATILE HORMONE RELEASE;

ADULT; CARRIER PROTEINS; GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 2; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED;

EID: 0030064807     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.1.84     Document Type: Article

References (41)

1. Arafah BM. 1986 Reversible hypopituitarism in patients with large nonfunctioning pituitary adenomas. J Clin Endocrinol Metab. 62:1173-1179.
2. Littley MD, Shalet SM, Beardwell CG, Ahmed SR, Applegate G, Sutton ML. 1989 Hypopituitarism following external radiotherapy for pituitary tumours in adults. Q J Med. 70:145-160.
3. Vance ML. 1994 Hypopituitarism. N Engl J Med. 330:1651-1662.
4. Harrop JS, Davies TJ, Capra LG, Marks V. 1976 Hypothalamic-pituitary function following successful treatment of intracranial tumours. Clin Endocrinol (Oxf). 5:313-321.
5. Shalet SM, Beardwell CG, Morris JP, Pearson D. 1975 Pituitary function after treatment of intracranial tumours in children. Lancet. 2:104-107.
6. Tanner JM, Hughes PC, Whitehouse RH. 1977 Comparative rapidity of response of height, limb muscle and limb fat to treatment with human growth hormone in patients with and without growth hormone deficiency. Acta Endocrinol (Copenh). 84:681-696.
7. Bing YRG, Denis MC, Rosen CJ. 1993 Low bone mineral density in adults with previous hypothalamic-pituitary tumors: correlations with serum growth hormone responses to GH-releasing hormone, insulin-like growth factor I, and IGF binding protein 3. Calcif Tissue Int. 52:183-187.
8. Holmes SJ, Economou G, Whitehouse RW, Adams JE, Shalet SM. 1994 Reduced bone mineral density in patients with adult onset growth hormone deficiency. J Clin Endocrinol Metab. 78:669-674.
9. Rosen T, Eden S, Larson G, Wilhelmsen L, Bengtsson BA. 1993 Cardiovascular risk factors in adult patients with growth hormone deficiency. Acta Endocrinol (Copenh). 129:195-200.
10. Bercu BB, Shulman D, Root AW, Spiliotis BE. 1986 Growth hormone (GH) provocative testing frequently does not reflect endogenous GH secretion [published erratum appears in J Clin Endocrinol Metab 1987 Feb;64(2):382]. J Clin Endocrinol Metab. 63:709-716.
11. Iranmanesh A, Grisso B, Veldhuis JD. 1994 Low basal and persistent pulsatile growth hormone secretion are revealed in normal and hyposomatotropic men studied with a new ultrasensitive chemiluminescence assay. J Clin Endocrinol Metab. 78:526-535.
12. Chapman IM, Hartman ML, Straume M, Johnson ML, Veldhuis JD, Thorner MO. 1994 Enhanced sensitivity growth hormone (GH) chemiluminescence assay reveals lower postglucose nadir GH concentrations in men than women. J Clin Endocrinol Metab. 78:1312-1319.
13. Smith WJ, Nam TJ, Underwood LE, Busby WH, Celnicker A, Clemmons DR. 1993 Use of insulin-like growth factor-binding protein-2 (IGFBP-2), IGFBP-3, and IGF-I for assessing growth hormone status in short children. J Clin Endocrinol Metab. 77:1294-1299.
14. Carlsson LM, Rowland AM, Clark RG, Gesundheit N, Wong WL. 1991 Ligand-mediated immunofunctional assay for quantitation of growth hormone-binding protein in human blood. J Clin Endocrinol Metab. 73:1216-1223.
15. Van CE, Kerkhofs M, Caufriez A, Van OA, Thorner MO, Copinschi G. 1992 A quantitative estimation of growth hormone secretion in normal man: reproducibility and relation to sleep and time of day. J Clin Endocrinol Metab. 74:1441-1450.
16. Salomon F, Cuneo RC, Hesp R, Sonksen PH. 1989 The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med. 321:1797-1803.
17. Bengtsson BA, Eden S, Lonn L, et al. 1993 Treatment of adults with growth hormone (GH) deficiency with recombinant human GH. J Clin Endocrinol Metab. 76:309-317.
18. Whitehead HM, Aiken B, Lewis S, Sheridan B, Hadden DR. 1991 Physiological growth hormone secretion in adult growth hormone deficiency: comparison with normal controls. Clin Endocrinol (Oxf). 34:371-376.
19. Rudman D, Kutner MH, Rogers CM, Lubin MF, Fleming GA, Bain RP. 1981 Impaired growth hormone secretion in the adult population: relation to age and adiposity. J Clin Invest. 67:1361-1369.
20. Zadik Z, Chalew SA, McCarter RJ, Meistas M, Kowarski AA. 1985 The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals. J Clin Endocrinol Metab. 60:513-516.
21. Reutens AT, Hoffman DM, Leung K-C, Ho KKY. 1995 Evaluation and application of a highly sensitive assay for serum growth hormone (GH) in the study of adult GH deficiency. J Clin Endocrinol Metab. 80:480-485.
22. Lee PD, Wilson DM, Rountree L, Hintz RL, Rosenfeld RG. 1990 Efficacy of insulin-like growth factor I levels in predicting the response to provocative growrth hormone testing. Pediatr Res. 27:45-51.
23. Rudman D, Feller AG, Nagraj HS, et al. 1990 Effects of human growth hormone in men over 60 years old. N Engl J Med. 323:1-6.
24. Dammacco F, Boghen MF, Camanni F, et al. 1993 Somatotropic function in short stature: evaluation by integrated auxological and hormonal indices in 214 children. The Italian Collaborative Group of Neuroendocrinology. J Clin Endocrinol Metab. 77:68-72.
25. Blum WF, Ranke MB, Kietzmann K, Gauggel E, Zeisel HJ, Bierich JR. 1990 A specific radioimmunoassay for the growth hormone (GH)-dependent somatomedin-binding protein: its use for diagnosis of GH deficiency. J Clin Endocrinol Metab. 70:1242-1298.
26. Hoffman DM, O'Sullivan AJ, Baxter RC, Ho KK. 1994 Diagnosis of growth-hormone deficiency in adults. Lancet. 343:1064-1068.
27. Hunt GE, OSullivan BT, Johnson GF, Smythe GA. 1986 Growth hormone and cortisol secretion after oral clonidine in healthy adults. Psychoneuroendocrinology. 11:317-325.
28. Bellastella A, Parlato F, Sinisi AA. 1990 Blindness impairs plasma growth hormone response to L-dopa but not to arginine. J Clin Endocrinol Metab. 70:856-858.
29. Greenwood FC, Landon J, Stamp TC. 1966 The plasma sugar, tree fatty acid, cortisol, and growth hormone response to insulin. I. In control subjects. J Clin Invest. 45:429-436.
30. Landon J, Greenwood FC, Stamp TC, Wynn V. 1966 The plasma sugar, free fatty acid, cortisol, and growth hormone response to insulin, and the comparison of this procedure with other tests of pituitary and adrenal function. II. In patients with hypothalamic or pituitary dysfunction or anorexia nervosa. J Clin Invest. 45:437-449.
31. Baxter R. 1991 Physiological roles of the IGF binding proteins. In: Spencer EM, ed, Modern concepts of insulin-like growth factors. New York: Elsevier; 371-380.
32. Shimasaki S, Shimonaka M, Zhang H-P, Ling N. 1991 Isolation and molecular characteristics of three novel insulin-like growth factor binding proteins (IGFBP-4, 5, and 6). In: Spencer EM, ed. Modern concepts of insulin-like growth factors. New York: Elsevier; 343-359.
33. Baxter RC, Martin JL. 1986 Radioimmunoassay of growth hormone-dependent insulinlike growth factor binding protein in human plasma. J Clin Invest. 78:1504-1512.
34. Young SC, Underwood LE, Celniker A, Clemmons DR. 1992 Effects of recombinant insulin-like growth factor-1 (IGF-I) and growth hormone on serum IGF-binding proteins in calorically restricted adults. J Clin Endocrinol Metab. 75:603-608.
35. Hall K, Lundin G, Povoa G. 1988 Serum levels of the low molecular weight form of insulin-like growth factor binding protein in healthy subjects and patients with growth hormone deficiency, acromegaly and anorexia nervosa. Acta Endocrinol (Copenh). 118:321-326.
36. Clemmons DR, Snyder DK, Busby WHJ. 1991 Variables controlling the secretion of insulin-like growth factor binding protein-2 in normal human subjects. J Clin Endocrinol Metab. 73:727-733.
37. Leung DW, Spencer SA, Cachianes G, et al. 1987 Growth hormone receptor and serum binding protein: purification, cloning and expression. Nature. 330: 537-543.
38. Postel VMC, Tar A, Hocquette JF, et al. 1991 Human plasma growth hormone (GH)-binding proteins are regulated by GH and testosterone. J Clin Endocrinol Metab. 73:197-202.
39. Tauber M, De BDPH, Sallerin CB, Rochiccioli P, Bastide R. 1993 Differential regulation of serum growth hormone (GH)-binding protein during continuous infusion versus daily injection of recombinant human GH in GH-deficient children. J Clin Endocrinol Metab. 76:1135-1139.
40. Hattori N, Kurahachi H, Ikekubo K, et al. 1991 Effects of sex and age on serum GH binding protein levels in normal adults. Clin Endocrinol (Oxf). 35:295-297.
41. Roelen CA, Donker GH, Thijssen JH, Koppeschaar HP, Blankenstein MA. 1992 High affinity growth hormone binding protein in plasma of patients with acromegaly and the effect of octreotide treatment. Clin Endocrinol (Oxf). 37:373-378.