Intratumour T cells, their activation status and survival in gastric carcinomas characterised for microsatellite instability and Epstein-Barr virus infection

Virchows Archiv

Volumn 448, Issue 3, 2006, Pages 344-353

  Chiaravalli, Anna Maria ^a,b   Feltri, Maddalena ^a   Bertolini, Valentina ^a   Bagnoli, Elena ^a   Furlan, Daniela ^a   Cerutti, Roberta ^a   Novario, Raffaele ^a   Capella, Carlo ^a  

^a UNIVERSITY OF INSUBRIA   (Italy)

^b OSPEDALE DI CIRCOLO   (Italy)

Author keywords

Activated cytotoxic T cells; Epstein Barr virus; Gastric carcinoma; Microsatellite instability; Survival; Tumour infiltrating lymphocytes

Indexed keywords

CASPASE; CD3 ANTIGEN; CD8 ANTIGEN; CYTOKERATIN 18; GRANZYME B; GRANZYME B MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD3; MONOCLONAL ANTIBODY CD57; MONOCLONAL ANTIBODY CD8; MONOCLONAL ANTIBODY M30; MONOCLONAL ANTIBODY TIA 1; PERFORIN MONOCLONAL ANTIBODY; T LYMPHOCYTE ANTIGEN; T LYMPHOCYTE INTRACELLULAR ANTIGEN 1; UNCLASSIFIED DRUG;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER INVASION; CANCER STAGING; CELL COUNT; CYTOTOXIC T LYMPHOCYTE; EPSTEIN BARR VIRUS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; PROTEIN DEGRADATION; STOMACH CARCINOGENESIS; STOMACH CARCINOMA; SURVIVAL RATE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR CELL; TUMOR DIFFERENTIATION; VIRUS INFECTION;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD3; APOPTOSIS; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOENZYME TECHNIQUES; LYMPHOCYTE ACTIVATION; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; NEOPLASM STAGING; STOMACH NEOPLASMS; SURVIVAL RATE; T-LYMPHOCYTES;

EID: 33644827779     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-005-0066-4     Document Type: Article

References (42)

1. Anderson P, Nagler-Anderson C, O'Brein C, Levine H, Watkins S, Slayter HS, Blue ML, Schlossman SF (1990) A monoclonal antibody reactive with a 15-kDa cytoplasmic granule-associated protein defines a subpopulation of Cd8+ T lymphocytes. J Immunol 144:574-582
2. Boon T, Cerottini JC, Van den Eynde B, van der Bruggen P, Van Pel A (1994) Tumor antigens recognized by T lymphocytes. Annu Rev Immunol 12:337-365
3. Carneiro F, Seixas M, Sobrinho-Simoes M (1995) New elements for an updated classification of carcinomas of the stomach. Pathol Res Pract 191:571-584
4. Chiaravalli AM, Cornaggia M, Furlan D, Capella C, Fiocca R, Tagliabue G, Klersy C, Solcia E (2001) The role of histological investigation in prognostic evaluation of advanced gastric cancer. Analysis of histological structure and molecular changes compared with invasive pattern and stage. Virchows Arch 439:158-169
5. Cho MY, Kim TH, Yi SY, Jung WH, Park KH (2004) Relationship between Epstein-Barr virus encoded RNA expression, apoptosis and lymphocytic infiltration in gastric carcinoma with lymphoid-rich stroma. Med Princ Pract 13:353-360
6. Chong JM, Fukayama M, Hayashi Y, Takizawa T, Koike M, Konishi M, Kikuchi-Yanoshita R, Miyaki M (1994) Microsatellite instability in the progression of gastric carcinoma. Cancer Res 54:4595-4597
7. Dolcetti R, Viel A, Doglioni C, Russo A, Guidoboni M, Capozzi E, Vecchiato N, Macri E, Fornasarig M, Boiocchi M (1999) High prevalence of activated intraepithelial cytotoxic T lymphocytes and increased neoplastic cell apoptosis in colorectal carcinomas with microsatellite instability. Am J Pathol 154(6):1805-1813
8. Elsaleh H, Powell B, Soontrapornchai P, Joseph D, Goria F, Spry N, Iacopetta B (2000) p53 gene mutation, microsatellite instability and adjuvant chemotherapy: impact on survival of 388 patients with Duke's C colon carcinoma. Oncology 58:52-59
9. Froelich CJ, Dixit VM, Yang X (1998) Lymphocyte granule-mediated apoptosis: matter of viral mimicry and deadly proteases. Immunol Today 19:30-36
10. Grogg KL, Lohse CM, Shane Pankratz V, Halling KC, Smyrk TC (2003) Lymphocyte-rich gastric cancer: association with Epstein-Barr virus, microsatellite instability, histology, and survival. Mod Pathol 16 (7):641-651
11. Gryfe R, Kim H, Hsieh ETK, Aronson MD, Holowaty EJ, Bull SB, Redston M, Gallinger S (2000) Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer. N Engl J Med 342:69-77
12. Halpern AC, Schuchter LM (1997) Prognostic models in melanoma. Semin Oncol 24(Suppl 4):S2-S7
13. Hayashi K, Yonamine K, Masuko-Hongo K, Iida T, Yamamoto K, Nishioka K, Kato T (1999) Clonal expansion of T cells that are specific for autologous ovarian tumor among tumor-infiltrating T cells in humans. Gynecol Oncol 74:86-92
14. Ishigami S, Natsugoe S, Tokuda K, Nakajo A, Che X, Iwashige H, Aridome K, Hokita S, Aikou T (2000) Prognostic value of intratumoral natural killer cells in gastric carcinoma. Cancer 88:577-583
15. Ishikawa T, Fujita T, Suzuki Y, Okabe S, Yuasa Y, Iwai T, Kawakami Y (2003) Tumor-specific immunological recognition of frameshift mutated peptides in colon cancer with microsatellite instability. Cancer Res 63:5564-5572
16. Kijima Y, Ishigami S, Hokita S, Koriyama C, Akiba S, Eizuru Y, Aikou T (2003) The comparison of the prognosis between Epstein-Barr virus (EBV)-positive gastric carcinomas and EBV-negative ones. Cancer Lett 200:33-40
17. Kooi S, Freedman RS, Rodriguez-Villanueva J, Platsoucas CD (1993) Cytokine production by T-cell lines derived from tumor-infiltrating lymphocytes from patients with ovarian carcinoma: tumor-specific immune responses and inhibition of antigen-independent cytokine production by ovarian tumor cells. Lymphokine Cytokine Res 12:429-437
18. Kuzushima K, Nakamura S, Nakamura T, Yamamura N, Yokoyama N, Fujita M, Kiyono T, Tsurumi T (1999) Increased frequency of antigen-specific CD8+ cytotoxic lymphocytes infiltrating an Epstein-Barr virus associated gastric carcinoma. J Clin Invest 140:163-171
19. Lauren P (1965) The two histological main type of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbiol Scand 64:31-49
20. Liu B, Nicolaides NC, Markowitz S, Willson JK, Parsons RE, Jen J, Papadopulos N, Peltomaki P, de la Chapelle A, Hamilton SR, Kinzler KW, Vogelstein B (1995) Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nat Genet 9:48-55
21. MacCarty WC, Mahle AE (1921) Relation of differentiation and lymphocytic infiltration to postoperative longevity in gastric carcinoma. J Lab Clin Med 6:473-480
22. Matsunou H, Konishi F, Hori H, Ikeda T, Sasaki K, Hirose Y, Yamamichi N (1996) Characteristics of Epstein-Barr virus-associated gastric carcinoma with lymphoid stroma in Japan. Cancer 77:1998-2004
23. Michael-Robinson JM, Biemer-Huttmann A-E, Purdie DM, Walsh M, Simms LA, Biden KG, Young JP, Leggett BA, Jass JR, Radford-Smith GL (2001) Tumor infiltrating lymphocytes and apoptosis are independent features in colorectal cancer stratified according to microsatellite instability status. Gut 48:360-366
24. Michael-Robinson JM, Reid LE, Purdie DM, Biemer-Huttmann A-E, Walsh MD, Pandeya N, Simms LA, Young JP, Leggett BA, Jass JR, Radford-Smith GL (2001) Proliferation, apoptosis and survival in high-level microsatellite instability sporadic colorectal cancer. Clin Cancer Res 7:2347-2356
25. Naito Y, Saito K, Shiiba K, Ohuci A, Saigenji K, Nagura H, Ohtani H (1998) CD8+ T cells infiltrated within cancer cell nests as prognostic factor in human colorectal cancer. Cancer Res 58:3491-3494
26. Nakamura S, Ueki T, Yao T, Ueyama T, Tsuneyoshi M (1994) Epstein-Barr virus in gastric carcinoma with lymphoid stroma. Cancer 73:2239-2249
27. Nakano O, Sato M, Naito Y, Suzuki K, Orikasa S, Aizawa M, Suzuki Y, Shintaku I, Nagura H, Ohtani H (2001) Proliferative activity of intratumoral CD8(+) T-lymphocytes as prognostic factor in human renal cell carcinoma: clinicopathologic demonstration of antitumor immunity. Cancer Res 61:5132-5136
28. Oda K, Tamaru J, Takenouchi T, Mikata A, Nunomura M, Saitoh N, Sarashina H, Nakajima N (1993) Association of Epstein-Barr virus with gastric carcinoma with lymphoid stroma. Am J Pathol 143:1063-1071
29. Peoples GE, Goedegebuure PS, Smith R, Linehan DC, Yoshino I, Eberlein TJ (1995) Breast and ovarian cancer-specific cytotoxic T lymphocytes recognize the same HER2/neuderived peptide. Proc Natl Acad Sci U S A 17:432-436
30. Pross HF, Lotzova E (1993) Role of natural killer cells in cancer. Nat Immunol 12:279-292
31. + T cells. Cancer Immunol Immunother 50:469-476
32. Santin AD, Bellone S, Ravaggi A, Pecorelli S, Cannon MJ, Parham GP (2000) Induction of ovarian tumor-specific CD8+ cytotoxic T lymphocytes by acid-eluted peptide-pulsed autologous dendritic cells. Obstet Gynecol 96:422-30
33. Santin AD, Hermonat PL, Ravaggi A, Bellone S, Roman JJ, Smith CV, Pecorelli S, Radominska-Pandya A, Cannon MJ, Parham GP (2001) Phenotypic and functional analysis of tumor-infiltrating lymphocytes compared with tumor-associated lymphocytes from ascitic fluid and peripheral blood lymphocytes in patients with advanced ovarian cancer. Gynecol Obstet Invest 51:254-261
34. Seruca R, Santos NR, David L, Constancia M, Barroca H, Carneiro F, Seixas M, Peltomaki P, Lothe R, Sobrinho-Simoes M (1995) Sporadic gastric carcinomas with microsatellite instability display a particular clinicopathologic profile. Int J Cancer 64:32-36
35. Sobin LH, Wittekind C (eds) (2002) TNM classification of malignant tumors, 6th edn. Wiley-Liss, New York
36. Stracca-Pansa V, Menegon A, Donisi PM, Bozzola L, Fedeli F, Quarto F, Nappi O, Pettinato G (1995) Gastric carcinoma with osteoclast-like giant cells. Report of four cases. Am J Clin Pathol 103:453-459
37. Tokunaga M, Land CE, Uemura Y, Tokudome T, Tanaka S, Sato E (1993) Epstein-Barr virus in gastric carcinoma. Am J Pathol 143:1250-1254
38. Vesalainen S, Lipponen P, Talia M, Syrjanen K (1994) Histological grade, perineural infiltration, tumor-infiltrating lymphocytes and apoptosis as determinants of long-term prognosis in prostatic adenocarcinoma. Eur J Cancer 30A:1797-1803
39. Watanabe H, Enjoji M, Imai T (1976) Gastric carcinoma with lymphoid stroma. Cancer 38:232-243
40. Wright CM, Dent OF, Barker M, Newland RC, Chapuis PH, Bokey EL, Young JP, Leggett BA, Jass JR, Macdonald GA (2000) Prognostic significance of extensive microsatellite instability in sporadic clinicopathological stage C colorectal cancer. Br J Surg 87:1197-1202
41. Yamamoto H, Perez-Piteira J, Yoshida T, Terada M, Itoh F, Imai K, Perucho M (1999) Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features. Gastroenterology 116:1348-1357
42. Zhang L, Conejo-Garcia JR, Katsaros D, Gimotty PA, Massobrio M, Regnani G, Makrigiannakis A, Gray H, Schlienger K, Liebman MN, Rubin SC, Coukos G (2003) Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med 348:203-213