Th2 cells support intrinsic anti-inflammatory properties of the brain

Journal of Neuroimmunology

Volumn 119, Issue 1, 2001, Pages 73-80

  Gimsa, Ulrike ^a   Wolf, Susanne A ^a   Haas, Dorit ^a   Bechmann, Ingo ^a   Nitsch, Robert ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Brain slice cultures; Costimulation; Experimental autoimmune encephalomyelitis; MBP; Microglial activation

Indexed keywords

CD40 ANTIGEN; GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 4; MYELIN BASIC PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN PROTECTION; BRAIN SLICE; CELL ACTIVATION; CELL FUNCTION; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENTORHINAL CORTEX; HIPPOCAMPUS; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REMISSION; TH1 CELL; TH2 CELL;

ANIMALS; ANTIGENS, CD40; BRAIN; CELL COMMUNICATION; CELL MOVEMENT; CYTOKINES; ENCEPHALITIS; INTERCELLULAR ADHESION MOLECULE-1; MICE; MICE, INBRED STRAINS; MICROGLIA; TH1 CELLS; TH2 CELLS;

EID: 0035801742     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(01)00343-5     Document Type: Article

References (32)

1. Copolymer 1 induces T cells of the T helper type 2 that crossreact with myelin basic protein and suppress experimental autoimmune encephalomyelitis
2. CD40-CD154 interaction and IFN-gamma are required for IL-12 but not prostaglandin E2 secretion by microglia during antigen presentation to Th1 cells
3. Sequential production of IL-2, IFN-gamma and IL-10 by individual staphylococcal enterotoxin B-activated T helper lymphocytes
4. Microglial production of TNF-alpha is induced by activated T lymphocytes: Involvement of VLA-4 and inhibition by interferonbeta-1b
5. Mechanisms of recovery from experimental autoimmune encephalomyelitis: T cell deletion and immune deviation in myelin basic protein T cell receptor transgenic mice
6. Accessory molecule and costimulation requirements for CD4 T cell response
7. The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions
8. The organotypic entorhinal-hippocampal complex slice culture of adolescent rats. A model to study transcellular changes in a circuit particularly vulnerable in neurodegenerative disorders
9. A T helper cell 2 (Th2) immune response against non-self antigens modifies the cytokine profile of autoimmune T cells and protects against experimental allergic encephalomyelitis
10. Axonal damage induced by invading T cells in organotypic central nervous system tissue in vitro: Involvement of microglial cells
11. A central role of CD40 ligand in the regulation of CD4+ T-cell responses
12. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis
13. Resting microglial cells in vitro: Analysis of morphology and adhesion molecule expression in organotypic hippocampal slice cultures
14. Fluorescent dye prelabelled microglial cells migrate into organotypic hippocampal slice cultures and ramify
15. Astrocytic factors deactivate antigen presenting cells that invade the central nervous system
16. Linomide downregulates autoimmunity through induction of TH2 cytokine production by lymphocytes
17. Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells
18. Tracing of the entorhinal-hippocampal pathway in vitro
19. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
20. Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease
21. Low avidity recognition of self-antigen by T cells permits escape from central tolerance
22. B cells regulate CD40 ligand-induced IL-12 production in antigen-presenting cells (APC) during T cell/APC interactions
23. Differential activation of microglia and astrocytes following trimethyl tin-induced neurodegeneration
24. Two types of murine helper T cell clone: I. Definition according to profiles of lymphokine activities and secreted proteins
25. Multiple sclerosis: Comparison of copolymer-1-reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells
26. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease
27. Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell cycle progression
28. Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis
29. The critical role of IL-12 and the IL-12R beta 2 subunit in the generation of pathogenic autoreactive Th1 cells
30. CD40L is important for induction of, but not response to, costimulatory activity: ICAM-1 as the second costimulatory molecule rapidly up-regulated by CD40L
31. Short term treatment with soluble neuroantigen and anti-CD11a (LFA-1) protects rats against autoimmune encephalomyelitis: Treatment abrogates autoimmune disease but not autoimmunity
32. Ligation of CD40 on fibroblasts induces CD54 (ICAM-1) and CD106 (VCAM-1) up-regulation and IL-6 production and proliferation