Structure of the mosquitocidal toxin from Bacillus sphaericus

Journal of Molecular Biology

Volumn 357, Issue 4, 2006, Pages 1226-1236

  Reinert, Dirk J ^a   Carpusca, Irina ^b   Aktories, Klaus ^b   Schulz, Georg E ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

ADP ribosyl transferases; NAD+ binding site; Pierisin; Toxin activation and inhibition; X ray crystallography

Indexed keywords

BACTERIAL TOXIN; MONOMER; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLYPEPTIDE; PROTEINASE; RICIN;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ARTICLE; BACILLUS SPHAERICUS; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; GEL PERMEATION CHROMATOGRAPHY; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION; X RAY DIFFRACTION;

BACILLUS SPHAERICUS; BACTERIA (MICROORGANISMS);

EID: 33644825968     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2006.01.025     Document Type: Article

References (44)

1. J.-F. Charles, C. Nielsen-LeRoux, and A. Delécluse Bacillus sphaericus toxins: molecular biology and mode of action Annu. Rev. Entomol. 41 1996 451 472
2. J.W. Liu, A.G. Porter, B.Y. Wee, and T. Thanabalu New gene from nine Bacillus sphaericus strains encoding highly conserved 35.8-kilodalton mosquitocidal toxins Appl. Environ. Microbiol. 62 1996 2174 2176
3. S.W. Chan, T. Thanabalu, B.Y. Wee, and A.G. Porter Unusual amino acid determinations of host range in the Mtx2 family of mosquitocidal toxins J. Biol. Chem. 271 1996 14183 14187
4. P. Baumann, M.A. Clark, L. Baumann, and A.H. Broadwell Bacillus sphaericus as a mosquito pathogen: properties of the organism and its toxins Microbiol. Rev. 55 1991 425 436
5. J.L. Schwartz, L. Potvin, F. Coux, J.F. Charles, C. Berry, and M.J. Humphreys Permeabilization of model lipid membranes by Bacillus sphaericus mosquitocidal binary toxin and its individual components J. Membr. Biol. 184 2001 171 183
6. T. Thanabalu, J. Hindley, J. Jackson-Yap, and C. Berry Cloning, sequencing, and expression of a gene encoding a 100-kilodalton mosquitocidal toxin from Bacillus sphaericus SSII-1 J. Bacteriol. 173 1991 2776 2785
7. T. Thanabalu, C. Berry, and J. Hindley Cytotoxicity and ADP-ribosylating activity of the mosquitocidal toxin from Bacillus sphaericus SSII-1: Possible roles of the 27- and 70-kilodalton peptides J. Bacteriol. 175 1993 2314 2320
8. B. Hazes, and R.J. Read A mosquitocidal toxin with a ricin-like cell-binding domain Nature Struct. Biol. 2 1995 358 359
9. 3 domain: a flexible lectin scaffold Protein Sci. 5 1996 1490 1501
10. E. Rutenber, M. Ready, and J.D. Robertus Structure and evolution of ricin B chain Nature 326 1987 624 626
11. Y. Matsushima-Hibiya, M. Watanabe, K.I.P.J. Hidari, D. Miyamoto, Y. Suzuki, and T. Kasama Identification of glycosphingolipid receptors for pierisin-1, a guanine-specific ADP-ribosylating toxin from the cabbage butterfly J. Biol. Chem. 278 2003 9972 9978
12. T. Thanabalu, J. Hindley, and C. Berry Proteolytic processing of the mosquitocidal toxin from Bacillus sphaericus SSII-1 J. Bacteriol. 174 1992 5051 5056
13. J. Schirmer, I. Just, and K. Aktories The ADP-ribosylating mosquitocidal toxin from Bacillus sphaericus: proteolytic activation, enzyme activity, and cytotoxic effects J. Biol. Chem. 277 2002 11941 11948
14. M. Watanabe, T. Kono, Y. Matsushima-Hibiya, T. Kanazawa, N. Nishisaka, and T. Kishimoto Molecular cloning of an apoptosis-inducing protein, pierisin, from cabbage butterfly: Possible involvement of ADP-ribosylation in its activity Proc. Natl Acad. Sci. USA 96 1999 10608 10613
15. Y. Matsushima-Hibiya, M. Watanabe, T. Kono, T. Kanazawa, K. Koyama, T. Sugimura, and K. Wakabayashi Purification and cloning of pierisin-2, an apoptosis-inducing protein from the cabbage butterfly, Pieris brassicae Eur. J. Biochem. 267 2000 5742 5750
16. T. Takamura-Enya, M. Watanabe, Y. Totsuka, T. Kanazawa, Y. Matsushima-Hibiya, and K. Koyama Mono(ADP-ribosyl)ation of 2′- deoxyguanosine residue in DNA by an apoptosis-inducing protein, pierisin-1, from cabbage butterfly Proc. Natl Acad. Sci. USA 98 2001 12414 12419
17. I. Carpusca, J. Schirmer, and K. Aktories Two-site autoinhibition of the ADP-ribosylating mosquitocidal toxin (MTX) from Bacillus sphaericus by its 70-kDa ricin-like binding domain Biochemistry 43 2004 12009 12019
18. J. Schirmer, H.-J. Wieden, M.V. Rodnina, and K. Aktories Inactivation of the elongation factor Tu by mosquitocidal toxin-catalyzed mono-ADP-ribosylation Appl. Environ. Microbiol. 68 2002 4894 4899
19. M. Domenighini, and R. Rappuoli Three conserved consensus sequences identify the NAD-binding site of ADP-ribosylating enzymes, expressed by eukaryotes, bacteria and T-even bacteriophages Mol. Microbiol. 21 1996 667 674
20. S. Han, A.S. Arvai, S.B. Clancy, and J.A. Tainer Crystal structure and novel recognition motif of Rho ADP-ribosylating C3 exoenzyme from Clostridium botulinum: Structural insights for recognition specificity and catalysis J. Mol. Biol. 305 2001 95 107
21. C. Mueller-Dieckmann, H. Ritter, F. Haag, F. Koch-Nolte, and G.E. Schulz Structure of the ecto-ADP-ribosyl transferase ART2.2 from rat J. Mol. Biol. 322 2002 687 696
22. L. Holm, and C. Sander Protein structure comparison by alignment of distance matrices J. Mol. Biol. 233 1993 123 138
23. T.K. Sixma, S.E. Pronk, K.H. Kalk, E.S. Wartna, and B.A.M. van Zanten Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli Nature 351 1991 371 378
24. R.-G. Zhang, D.L. Scott, M.L. Westbrook, S. Nance, B.D. Spangler, G.G. Shipley, and E.M. Westbrook The three-dimensional crystal structure of cholera toxin J. Mol. Biol. 251 1995 563 573
25. P.E. Stein, A. Boodhoo, G.D. Armstrong, S.A. Cockle, M.H. Klein, and R.J. Read The crystal structure of pertussis toxin Structure 2 1994 45 57
26. C.J. O'Neal, M.G. Jobling, R.K. Holmes, and W.G.J. Hol Structural basis for the activation of cholera toxin by human ARF6-GTP Science 309 2005 1093 1096
27. S.F. Altschul, T.L. Madden, A.A. Schäffer, J. Zhang, Z. Zhang, W. Miller, D.J. Lipman, and B.L.A.S.T. Gapped and PSI-BLAST: a new generation of protein database search programs Nucl. Acids Res. 25 1997 3389 3402
28. G.E. Schulz Binding of nucleotides by proteins Curr. Opin. Struct. Biol. 2 1992 61 67
29. S. Doublie Preparation of selenomethionyl proteins for phase determination Methods Enzymol. 276 1997 523 530
30. W. Kabsch Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants J. Appl. Crystallog. 26 1993 795 800
31. T.R. Schneider, and G.M. Sheldrick Substructure solution with SHELXD Acta Crystallog. sect. D 58 2002 1772 1779
32. E. de la Fortelle, and G. Bricogne Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods Methods Enzymol. 276 1997 472 494
33. T.C. Terwilliger Maximum likelihood density modification Acta Crystallog. sect. D 56 2000 965 972
34. A. Perrakis, R. Morris, and V.S. Lamzin Automated protein model building combined with iterative structure refinement Nature Struct. Biol. 6 1999 458 463
35. P. Emsley, and K. Cowtan Coot: Model-building tools for molecular graphics Acta Crystallog. sect. D 60 2004 2126 2132
36. P.I.W. de Bakker, M.A. DePristo, D.F. Burke, and T.L. Blundell Ab initio construction of polypeptide fragments: Accuracy of loop decoy discrimination by an all-atom statistical potential and the AMBER force field with the Generalized Born solvation model Proteins: Struct. Funct. Genet. 51 2002 21 40
37. E. Blanc, P. Roversi, C. Vonrhein, C. Flensburg, S.M. Lea, and G. Bricogne Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT Acta Crystallog. sect. D 60 2004 2210 2221
38. A.J. McCoy, R.W. Grosse-Kunstleve, L.C. Storoni, and R.J. Read Likelihood-enhanced fast translation functions Acta Crystallog. sect. D 61 2005 458 464
39. G.N. Murshudov, A.A. Vagin, and E.J. Dodson Refinement of macromolecular structures by the maximum-likelihood method Acta Crystallog. sect. D 53 1997 240 255
40. R.W.W. Hooft, G. Vriend, C. Sander, and E.E. Abola Errors in protein structures Nature 381 1996 272
41. S.C. Lovell, I.W. Davis, W.B. Arendall 3rd, P.I. de Bakker, J.M. Word, and M.G. Prisant Structure validation by C-alpha geometry: phi, psi, and C-beta deviation Proteins: Struct. Funct. Genet. 50 2003 437 450
42. E. Krissinel, and K. Henrick Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions Acta Crystallog. sect. D 60 2004 2256 2268
43. G.J. Kleywegt Use of non-crystallographic symmetry in protein structure refinement Acta Crystallog. sect. D 52 1996 842 857
44. T.D. Fenn, D. Ringe, and G.A. Petsko POVScript+: A program for model and data visualization using persistence of vision ray-tracing J. Appl. Crystallog. 36 2003 944 947