Dμ expression causes enrichment of MZ B cells, but is non permissive for B cell maturation in Rag2-/- mice even if combined with Bcl-2

Molecular Immunology

Volumn 43, Issue 9, 2006, Pages 1316-1324

  Wikström, Ingela ^a   Bergqvist, Ingela ^a   Holmberg, Dan ^a   Forssell, Johan ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

Bcl 2; Marginal zone B cells; Pre B cells; Pro B cells; Rag2

Indexed keywords

B LYMPHOCYTE RECEPTOR; CELL PROTEIN; LEUKOSIALIN; PROTEIN BCL 2; PROTEIN DMU; RAG2 PROTEIN; UNCLASSIFIED DRUG; DNA; DNA BINDING PROTEIN; IMMUNOGLOBULIN MU CHAIN; RAG2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; BIOTINYLATION; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; OVARY FOLLICLE CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE; WESTERN BLOTTING; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; GENE EXPRESSION; GENE REARRANGEMENT; GENETICS; HUMAN; IMMUNOLOGY; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PROTO ONCOGENE;

ANIMALIA; MUS MUSCULUS;

ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; CELL DIFFERENTIATION; DNA; DNA-BINDING PROTEINS; GENE EXPRESSION; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENES, BCL-2; HUMANS; IMMUNOGLOBULIN MU-CHAINS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC;

EID: 33644820940     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2005.09.020     Document Type: Article

References (41)

1. F.W. Alt, G.D. Yancopoulos, T.K. Blackwell, C. Wood, E. Thomas, M. Boss, R. Coffman, N. Rosenberg, S. Tonegawa, and D. Baltimore Ordered rearrangement of immunoglobulin heavy chain variable region segments EMBO J. 3 1984 1209 1219
2. L. Carlsson, and D. Holmberg Genetic basis of the neonatal antibody repertoire: germline V-gene expression and limited N-region diversity Int. Immunol. 2 1990 639 643
3. L. Carlsson, C. Overmo, and D. Holmberg Developmentally controlled selection of antibody genes: characterization of individual VH7183 genes and evidence for stage- specific somatic diversification Eur. J. Immunol. 22 1992 71 78
4. T.L. Carvalho, T. Mota-Santos, A. Cumano, J. Demengeot, and P. Vieira Arrested B lymphopoiesis and persistence of activated B cells in adult interleukin 7(-/)- mice J. Exp. Med. 194 2001 1141 1150
5. X. Chen, F. Martin, K.A. Forbush, R.M. Perlmutter, and J.F. Kearney Evidence for selection of a population of multi-reactive B cells into the splenic marginal zone Int. Immunol. 9 1997 27 41
6. A.M. Cheng, B. Rowley, W. Pao, A. Hayday, J.B. Bolen, and T. Pawson Syk tyrosine kinase required for mouse viability and B-cell development Nature 378 1995 303 306
7. T.E. Costa, H. Suh, and M.C. Nussenzweig Chromosomal position of rearranging gene segments influences allelic exclusion in transgenic mice Proc. Natl. Acad. Sci. U.S.A. 89 1992 2205 2208
8. T. Fang, B.P. Smith, and C.A. Roman Conventional and surrogate light chains differentially regulate Ig mu and Dmu heavy chain maturation and surface expression J. Immunol. 167 2001 3846 3857
9. S. Gong, M. Sanchez, and M.C. Nussenzweig Counterselection against D mu is mediated through immunoglobulin (Ig)alpha-Igbeta J. Exp. Med. 184 1996 2079 2084
10. H. Gu, D. Kitamura, and K. Rajewsky B cell development regulated by gene rearrangement: arrest of maturation by membrane-bound D mu protein and selection of DH element reading frames Cell 65 1991 47 54
11. H. Gu, D. Kitamura, and K. Rajewsky DH reading frame bias: evolutionary selection, antigen selection or both? Evolutionary selection Immunol. Today 12 1991 420 421
12. Z. Hao, and K. Rajewsky Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow J. Exp. Med. 194 2001 1151 1164
13. K. Hayashi, M. Yamamoto, T. Nojima, R. Goitsuka, and D. Kitamura Distinct signaling requirements for Dmu selection, IgH allelic exclusion, pre-B cell transition, and tumor suppression in B cell progenitors Immunity 18 2003 825 836
14. M.C. Horne, P.E. Roth, and A.L. DeFranco Assembly of the truncated immunoglobulin heavy chain D mu into antigen receptor-like complexes in pre-B cells but not in B cells Immunity 4 1996 145 158
15. N. Hozumi, and S. Tonegawa Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions Proc. Natl. Acad. Sci. U.S.A. 73 1976 3628 3632
16. Y. Ichihara, H. Hayashida, S. Miyazawa, and Y. Kurosawa Only DFL16, DSP2, and DQ52 gene families exist in mouse immunoglobulin heavy chain diversity gene loci, of which DFL16 and DSP2 originate from the same primordial DH gene Eur. J. Immunol. 19 1989 1849 1854
17. A. Iglesias, M. Kopf, G.S. Williams, B. Buhler, and G. Kohler Molecular requirements for the mu-induced light chain gene rearrangement in pre-B cells EMBO J. 10 1991 2147 2155
18. H. Karasuyama, A. Kudo, and F. Melchers The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain J. Exp. Med. 172 1990 969 972
19. D. Kitamura, A. Kudo, S. Schaal, W. Muller, F. Melchers, and K. Rajewsky A critical role of lambda 5 protein in B cell development Cell 69 1992 823 831
20. G. Kraal, and M. Janse Marginal metallophilic cells of the mouse spleen identified by a monoclonal antibody Immunology 58 1986 665 669
21. A. Kudo, and F. Melchers A second gene, VpreB in the lambda 5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes EMBO J. 6 1987 2267 2272
22. Y. Kurosawa, and S. Tonegawa Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments J. Exp. Med. 155 1982 201 218
23. B.A. Malynn, A.C. Shaw, F. Young, V. Stewart, and F.W. Alt Truncated immunoglobulin Dmu causes incomplete developmental progression of RAG-deficient pro-B cells Mol. Immunol. 38 2002 547 556
24. J. Manz, K. Denis, O. Witte, R. Brinster, and U. Storb Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains J. Exp. Med. 168 1988 1363 1381
25. M.C. Nussenzweig, A.C. Shaw, E. Sinn, D.B. Danner, K.L. Holmes, H.C. Morse 3rd, and P. Leder Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu Science 236 1987 816 819
26. M.W. Quong, A. Martensson, A.W. Langerak, R.R. Rivera, D. Nemazee, and C. Murre Receptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2A J. Exp. Med. 199 2004 1101 1112
27. M. Reth, E. Petrac, P. Wiese, L. Lobel, and F.W. Alt Activation of V kappa gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains EMBO J. 6 1987 3299 3305
28. M.G. Reth, and F.W. Alt Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells Nature 312 1984 418 423
29. A. Rolink, U. Grawunder, T.H. Winkler, H. Karasuyama, and F. Melchers IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development Int. Immunol. 6 1994 1257 1264
30. S. Rusconi, and G. Kohler Transmission and expression of a specific pair of rearranged immunoglobulin mu and kappa genes in a transgenic mouse line Nature 314 1985 330 334
31. N. Sakaguchi, and F. Melchers Lambda 5, a new light-chain-related locus selectively expressed in pre-B lymphocytes Nature 324 1986 579 582
32. H. Sakano, R. Maki, Y. Kurosawa, W. Roeder, and S. Tonegawa Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes Nature 286 1980 676 683
33. A.C. Shaw, W. Swat, R. Ferrini, L. Davidson, and F.W. Alt Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes J. Exp. Med. 189 1999 123 129
34. E. Spanopoulou, C.A. Roman, L.M. Corcoran, M.S. Schlissel, D.P. Silver, D. Nemazee, M.C. Nussenzweig, S.A. Shinton, R.R. Hardy, and D. Baltimore Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice Genes Dev. 8 1994 1030 1042
35. S. Tonegawa Somatic generation of antibody diversity Nature 302 1983 575 581
36. U.C. Tornberg Molecular genetics of B lymphocyte development Dept of Cell and Molecular Biology 1999 Umeå University Umeå p. 62
37. U.C. Tornberg, I. Bergqvist, M. Haury, and D. Holmberg Regulation of B lymphocyte development by the truncated immunoglobulin heavy chain protein Dmu J. Exp. Med. 187 1998 703 709
38. T. Tsubata, and M. Reth The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface J. Exp. Med. 172 1990 973 976
39. D. Weaver, F. Costantini, T. Imanishi-Kari, and D. Baltimore A transgenic immunoglobulin mu gene prevents rearrangement of endogenous genes Cell 42 1985 117 127
40. F. Young, B. Ardman, Y. Shinkai, R. Lansford, T.K. Blackwell, M. Mendelsohn, A. Rolink, F. Melchers, and F.W. Alt Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation Genes Dev. 8 1994 1043 1057
41. F. Young, E. Mizoguchi, A.K. Bhan, and F.W. Alt Constitutive Bcl-2 expression during immunoglobulin heavy chain-promoted B cell differentiation expands novel precursor B cells Immunity 6 1997 23 33