Suckling rats actively recycle carbon from α-linolenate into newly synthesized lipids even during extreme dietary deficiency of n-3 polyunsaturates

Pediatric Research

Volumn 59, Issue 1, 2006, Pages 107-110

  Cunnane, Stephen C ^a   Ryan, Mary Ann ^a   Yu, Hong Lin ^b   Lim, Sun Young ^c   Salem Jr , Norman ^b  

^a UNIVERSITY INSTITUTE OF GERIATRICS OF SHERBROOKE   (Canada)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^c Korea Maritime University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; CARBON 13; CHOLESTEROL; DOCOSAHEXAENOIC ACID; FATTY ACID; LINOLENIC ACID; LIPID; OMEGA 3 FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; BRAIN; BREEDING; CARBON CYCLING; CONTROLLED STUDY; ESSENTIAL FATTY ACID DEFICIENCY; FATTY ACID METABOLISM; FEEDING; FEMALE; ISOTOPE LABELING; LIPOGENESIS; LIVER; NEWBORN; NEWBORN PERIOD; NONHUMAN; NUTRITIONAL DEFICIENCY; PRIORITY JOURNAL; RAT; SUCKLING; WEANING; ANIMAL; BIOSYNTHESIS; BRAIN LEVEL; CHEMISTRY; LONG EVANS RAT; METABOLISM;

ALPHA-LINOLENIC ACID; ANIMALS; ANIMALS, SUCKLING; BRAIN CHEMISTRY; CARBON; FATTY ACIDS, OMEGA-3; FEMALE; LIPIDS; LIVER; RATS; RATS, LONG-EVANS;

EID: 33644819004     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.pdr.0000190569.07991.ed     Document Type: Article

References (20)

1. 14C]linoleate for de novo lipid synthesis in pregnant rats. Can J Physiol Pharmacol 73:1246-1252
2. Cunnane SC, Anderson MJ 1997 The majority of dietary linoleate in growing rats is β-oxidized or stored in visceral fat. J Nutr 127:146-152
3. Sinclair AJ 1975 Incorporation of radioactive polyunsaturated fatty acids into liver and brain of the developing rat. Lipids 10:175-184
4. 14C]-α-linolenic acid into brain fatty acids. Lipids 10:238-241
5. 14C]-α-linolenic acid into brain lipids. Lipids 10:242-247
6. 13C]-linolenate utilization in the developing rat brain. J Neurochem 71:2151-2158
7. Cunnane SC, Ryan MA, Nadeau CR, Bazinet RP, Musa-Veloso K, McCloy U 2003 Why is carbon from some polyunsaturates extensively recycled into lipid synthesis? Lipids 38:477-484
8. Williard DE, Harmon SD, Kaduce TL, Preuss M, Moore SA, Robbins ME, Spector AA 2001 Docosahexaenoic acid synthesis from n-3 polyunsaturated fatty acids in differentiated rat brain astrocytes. J Lipid Res 42:1368-1376
9. 8a.Demar JC Jr, Ma C, Chang L, Rapoport SI 2005 alpha-Linolenic acid does not contribute appreciably to docosahexaenoic acid within brain phospholipids of adult rats fed a diet rich in docosahexaenoic acid. J Neurochem 94:1063-1076
10. Sheaff Greiner RC, Zhang Q, Goodman KJ, Guissani DA, Nathanielsz PW, Brenna JT 1996 Linoleate, α-linolenate and docosahexaenoate recycling into saturated and monounsaturated fatty acids is a major pathway in pregnant or lactating adults and fetal or infant rhesus monkeys. J Lipid Res 37:2675-2686
11. Burdge GC, Wootton SA 2003 Conversion of α-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women. Prostaglandins Leukot Essent Fatty Acids 69:283-290
12. Cunnane SC, Belza K, Anderson MJ, Ryan MA 1998 Substantial carbon recycling from linoleate into products of de novo lipogenesis occurs in rat liver even under conditions of extreme linoleate deficiency. J Lipid Res 39:2271-2276
13. Salem N Jr, Litman B, Kim HY, Gawrisch K 2001 Mechanisms of action of docosahexaenoic acid in the nervous system. Lipids 36:945-959
14. Salem N Jr. 1989 Omega-3 fatty acids: molecular and biochemical aspects. In: Spiller G, Scala J (eds) New Protective Roles of Selected Nutrients in Human Nutrition. Alan R. Liss, New York, pp 109-228
15. Lim SY, Doherty JD, McBride K, Miller-Ihli NJ, Carmona GN, Stark KD, Salem N Jr. 2005 Lead exposure and (n-3) deficiency during rat neonatal development affect subsequent spatial task performance and olfactory discrimination. J Nutr 135:1019-1026.
16. 13C-unsaturated fatty acids in healthy women. J Lipid Res 45:474-485
17. Moriguchi T, Loewke T, Garrison M, Catalan JN, Salem N Jr 2001 Reversal of docosahexaenoic acid deficiency in the rat brain, retina, river and serum. J Lipid Res 42: 419-427
18. Moriguchi T, Salem N Jr 2003 Recovery of brain docosahexaenoate leads to recovery of spatial task performance. J Neurochem 87: 297-309.
19. Su HM, Bernardo L, Mirmiran M, Ma XH, Corso TN, Nathanielsz PW, Brenna JT 1999 Bioequivalence of dietary α-linolenic and docosahexaenoic acids as sources of docosahexaenoate accretion in brain and associated organs of neonatal baboons. Pediatr Res 45:87-93
20. Lefkowitz W, Lim SY, Lin Y, Salem N Jr. 2005 Where does the developing brain obtain its docosahexaenoic acid? Relative contributions of dietary alpha-linolenic acid, docosahexaenoic acid and body stores in the developing rat. Pediatr Res 57:157-165