Linoleate, α-linolenate, and docosahexaenoate recycling into saturated and monounsaturated fatty acids is a major pathway in pregnant or lactating adults and fetal or infant rhesus monkeys

Journal of Lipid Research

Volumn 37, Issue 12, 1996, Pages 2675-2686

  Sheaff Greiner, Rebecca C ^a   Zhang, Qi ^a   Goodman, Keith J ^a,b   Giussani, Dino A ^a   Nathanielsz, Peter W ^a   Brenna, J Thomas ^a  

^a Department of Population Medicine and Diagnostic Sciences   (United States)

^b Metabolic Solutions   (United States)

Author keywords

linolenic acid; 13C labeling; Docosahexaenoic acid; Fatty acid recycling; Isotope ratio mass spectrometry; Linoleic acid; Rhesus monkeys

Indexed keywords

DOCOSAHEXAENOIC ACID; LINOLEIC ACID; LINOLENIC ACID; MONOUNSATURATED FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; FATTY ACID DESATURATION; FETUS DEVELOPMENT; ISOTOPE LABELING; LIPOPROTEIN METABOLISM; MASS SPECTROMETRY; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; RHESUS MONKEY; TISSUE GROWTH;

ANIMALS; DOCOSAHEXAENOIC ACIDS; FATTY ACIDS; FATTY ACIDS, MONOUNSATURATED; FEMALE; FETUS; LACTATION; LINOLEIC ACID; LINOLEIC ACIDS; MACACA MULATTA; PREGNANCY; PREGNANCY, ANIMAL;

EID: 0030477748     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Salem, N., Jr. 1989. Omega-3 fatty acids: molecular and biochemical aspects. In New Protective Roles for Selective Nutrients. G. Spiller, editor. Alan R. Liss Inc., New York. 109-228.
2. Carlson, S. E., S. E. Workman, J. M. Peeples, and W. M. Wilson III. 1994. Growth and development of premature infants in relation to 3 and 6 fatty acids status. In Fatty Acids and Lipids: Biological Aspects. C. Galli, A. P. Simopoulous, and E. Tremoli, editors. S. Karger, Basel, Switzerland. 63-69.
3. Neuringer, M., W. E. Connor, C. V. Petten, and L. Barstad. 1984. Dietary omega-3-fatty acid deficiency and visual loss in infant rhesus monkeys. J. Clin. Invest 73: 272-276.
4. Connor, W. E., M. Neuringer, and S. Reisbick. 1992. Essential fatty acids: the importance of n-3 fatty acids in the retina and brain. Nutr. Rev. 50: 21-29.
5. Hoffman, D. R., E. E. Birch, D. G. Birch, and R. D. Uauy. 1993. Effects of supplementation with omega-3 long-chain polyunsaturated fatty-acids on retinal and cortical development in premature-infants. Am. J. Clin. Nutr. 57: 807S-812S.
6. Carlson, S. E., S. H. Werkman, P. G. Rhodes, and E. A. Tolley. 1993. Visual acuity development in healthy preterm infants: effect of marine-oil supplementation. Am. J. Clin. Nutr. 58: 35-42.
7. Carlson, S. E., P. G. Rhodes, and M. G. Ferguson. 1986. Docosahexaenoic acid status of preterm infants at birth and following feeding with human milk or formula. Am. J. Clin. Nutr. 44: 798-804.
8. Uauy, R. D., D. G. Birch, E. E. Birch, J. E. Tyson, and D. R. Hoffman. 1990. Effect of dietary omega-3-fatty-acids on retinal function of very-low-birth-weight neonates. Pediatr. Res. 28: 485-492.
9. 14C]linolenate in developing rat brain. Biochim. Biaphys. Acta. 575: 309-317.
10. 1-linolenic acid to docosahexaenoic acid in the rat. Lipids. 11: 194-202.
11. Anderson, G. J., D. S. Lin, W. E. Connor, and J. D. Corliss. 1989. Rapid modulation of the n-3 docosahexaenoic acid levels in the brain and retina of the newly hatched chick. J. Lipid Res. 30: 433-441.
12. Lin, D. S., W. E. Connor, G. J. Anderson, and M. Neuringer. 1990. Effects of dietary n-3 fatty-acids on the phospholipid molecular-species of monkey brain. J. Neurochem. 55: 1200-1207.
13. Lin, D. S., W. E. Connor, and G. J. Anderson. 1991. The incorporation of n-3 and n-6 essential fatty acids into the chick embryo from egg yolks having vastly different fatty acid compositions. Pediatr. Res. 29: 601-605.
14. Stinson, A. M., R. D. Wiegand, and R. E. Anderson. 1991. Recycling of docosahexaenoic acid in rat retinas during n-3 fatty acid deficiency. J. Lipid Res. 32: 2009-2017.
15. Bourre, J. M., M. Bonneil, M. Clement, O. Dumont, G. Durand, H. Lafont, G. Nalbone, and M. Piciotti. 1993. Function of dietary polyunsaturated fatty-acids in the nervous-system. Prostaglandins Leukot. Essent. Fatty Acids. 48: 5-15.
16. Mohrhauser, H., and R. T. Holman. 1963. The effect of dose level of essential fatty acids upon fatty acid composition of rat liver. J. Lipid Res. 6: 494-497.
17. Christiansen, K., Y. Marcel, M. V. Gan, H. Hohrhauer, and R. T. Holman. 1968. Chain elongation of α- and γ-linolenic acids and the effect of other fatty acids on their conversion in vitro. J. Biol. Chem. 243: 2969-2974.
18. Putnam, J. C., S. E. Carlson, P. W. DeVoe, and L. A. Barness. 1982. The effect of variations in dietary fatty-acids on the fatty acids composition of erythrocyte phosphatidylcholine and phosphatidylethanolamine in human infants. Am. J. Clin. Nutr. 36: 106-114.
19. Uauy, R., E. Birch, D. Birch, and P. Peirano. 1992. Visual and brain function measurements in studies of n-3 fatty acid requirements of infants. J. Pediatr. 120: S168-S180.
20. Sheaff, R. C., H-M. Su, L. A. Keswick, and J. T. Brenna. 1995. Conversion of α-linolenate to docosahexaenoate is not depressed by high dietary levels of linoleate in young rats: tracer evidence using high precision mass spectrometry. J. Lipid Res. 36: 998-1008.
21. Leyton, J., P. J. Drury, and M. A. Crawford. 1987. Differential oxidation of saturated and unsaturated fatty acids in vivo in the rat. Br. J. Nutr. 57: 383-393.
22. Sinclair, A. J. 1975. Incorporation of radioactive polyunsaturated fatty acids into liver and brain of developing rats. Lipids. 10: 175-184.
23. Anderson, G. J., W. E. Connor, and J. D. Corliss. 1990. Docosahexaenoic acid is the preferred dietary n-3 fatty-acid for the development of the brain and retina. Pediatr. Res. 27: 89-97.
24. 14C]linolenic acid into adult rat brain. Biochim. Biophys. Acta. 239: 162-167.
25. 14C linolenic acid. Lipids. 11: 67-71.
26. 14C-linolenic acid into brain fatty acids. Lipids. 10: 238-241.
27. Scott, B. L., and N. L. Bazan. 1989. Membrane docosahexaenoate is supplied to the developing brain and retina by the liver. Proc. Natl. Acad. Sci. USA. 86: 2903-2907.
28. Li, J., M. G. Wetzel, and P.J. O'Brien. 1992. Transport of n-3 fatty acids from the intestine to the retina in rats. J. Lipid Res. 33: 539-548.
29. 13C-polyunsaturated fatty acids in the synthesis of long-chain fatty acids and cholesterol accumulating in the neonatal rat brain. J. Neurochem. 62: 2429-2436.
30. Crawford, M. A. 1987. The requirements of long chain n-6 and n-3 fatty acids for the brain. In Polyunsaturated Fatty Acids and Eicosanoids. W. E. M. Lands, editor. American Oil Chemists Society, Champaign, IL. 270-295.
31. Dohhing, J., and J. Sands. 1979. Comparative aspects of the brain growth spurt. Early Hum. Dev. 3/1: 79-83.
32. Cheek, D. B. 1975. Fetal and Postnatal Cellular Growth: Hormones and Nutrition. John Wiley and Sons, New York, NY. 3-22.
33. Hendrickx, A. G. 1971. Embryology of the Baboon. The University of Chicago Press, Chicago, IL.
34. 13C]-labeled precursors. Anal. Chem. 64: 1088-1095.
35. Guo, Z. K., A. H. Luke, W. P. Lee, and D. Schoeller. 1993. Compound-specific carbon isotope ratio determination of enriched cholesterol. Anal. Chem. 65: 1954-1959.
36. Brossard, N., C. Pachiaudi, M. Croset, S. Normand, J. Lecerf, V. Chirouze, J. P. Riou, J. L. Tayot, and M. Lagarde. 1994. Stable isotope tracer and gas-chromatography combustion isotope ratio mass spectrometry to study in vivo compartmental metabolism of docosahexaenoic acid. Anal. Biochem. 220: 192-199.
37. Cunnane, S. C., M. A. Ryan, K. S. Craig, S. Brookes, B. Koletzko, H. Demmelmair, J. Singer, and D. J. Kyle. 1995. Synthesis of linoleate and α-linolenate by chain elongation in the rat. Lipids. 30: 781-783.
38. Brenna, J. T. 1994. High-precision gas isotope ratio mass spectrometry: recent advances in instrumentation and biomedical applications. Acc. Chem. Res. 27: 340-346.
39. Brenna, J. T., K. J. Goodman, and P. W. Nathanielsz. 1993. Interconversion of α-linolenic acid in lactating rhesus monkeys. In Proceedings of The First Congress of the International Society for the Study of Fatty Acids and Other Lipids. Lugano, Switzerland.
40. Sheaff, R. C., P. W. Nathanielsz, and J. T. Brenna. 1995. Interconversion of α-linolenate and docosahexaenoate in fetal rhesus monkey. FASEB J. 9: A464.
41. Nathanielsz, P. W., J. P. Figueroa, and E. R. Poore. 1984. Methods of investigation of the chronically instrumented pregnant maintain on a tether and swivel system. In Animals Models in Fetal Medicine. P. W. Nathanielsz, editor. Perinatology Press, Ithaca, NY. 110-160.
42. Taylor, N. F., M. C. Martin, P. W. Nathanielsz, and M. Seron-Ferre. 1983. The fetus determines the circadian oscillation of myometrial electromyographic activity in the pregnant rhesus monkey. Am. J. Obstet. Gynecol. 146: 557-567.
43. Figueroa, J. P., M. B. O. M. Honnebier, Z. Binienda, J. Winsatt, and P. W. Nathanielsz. 1989. Effect of a 48-hour intravenous D4-androstenedione infusion to the pregnant rhesus in the last third of gestation: changes in maternal plasma estradiol concentrations and myometrial contractility. Am. J. Obstet. Gynecol. 161: 481-486.
44. Bligh, E. G., and W. J. Dyer. 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37: 911-917.
45. Crawford, M. A., A. G. Gassan, G. Williams, and W. L. Whitehouse. 1976. Essential fatly acids and fetal brain growth. Lancet. 1: 452-453.
46. Martinez, M. 1992. Tissue levels of polyunsaturated fatty acids during early human development. J. Pediatr. 120: S129-S138.
47. Portman, O. W., R. E. Behrman, and P. Soltys. 1969. Transfer of free fatty acids across the primate placenta. Am. J. Physiol. 216: 143-147.
48. Sinclair, A. J., and M. A. Crawford. 1972. The incorporation of linolenic acid and docosahexaenoic acid into liver and brain lipids of developing rats. FEBS Lett. 26: 127-129.
49. Anderson, G. J., and W. E. Connor. 1988. Uptake of fatty acids by developing rat brain. Lipids. 23: 286-290.
50. Wang, N., and R. E. Anderson. 1993. Synthesis of docosahexaenoic acid by retina and retinal pigment epithelium. Biochemistry. 32: 13703-13709.