Dehydroepiandrosterone causes hyperplasia and impairs regeneration in rat liver

International Journal of Oncology

Volumn 27, Issue 6, 2005, Pages 1551-1558

  Kopplow, Kathrin ^a   Wayss, Klaus ^a   Enzmann, Harald ^b   Mayer, Doris ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b Experimental Pharmacology and Toxicology   (Germany)

Author keywords

Dehydroepiandrosterone; Hyperplasia; Interleukin 6; Liver; Liver regeneration; Mitogen; Signal transducer and activator 3; Steroid hormones

Indexed keywords

ALANINE AMINOTRANSFERASE; ANDROSTENEDIONE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CYCLIN E; CYCLINE; ESTRADIOL; IMMUNOLOGICAL ADJUVANT; KI 67 ANTIGEN; PRASTERONE; PRASTERONE SULFATE; STAT3 PROTEIN; TESTOSTERONE;

ANIMAL; ARTICLE; BLOOD; BODY WEIGHT; COMPARATIVE STUDY; DRUG EFFECT; FEMALE; FLOW CYTOMETRY; HYPERPLASIA; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIVER; LIVER CELL; LIVER REGENERATION; LIVER RESECTION; MALE; METABOLISM; METHODOLOGY; ORGAN SIZE; PATHOLOGY; PLOIDY; RAT; SPRAGUE DAWLEY RAT; TIME;

ADJUVANTS, IMMUNOLOGIC; ALANINE TRANSAMINASE; ANDROSTENEDIONE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BILIRUBIN; BODY WEIGHT; CYCLIN E; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; ESTRADIOL; FEMALE; FLOW CYTOMETRY; HEPATECTOMY; HEPATOCYTES; HYPERPLASIA; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; LIVER; LIVER REGENERATION; MALE; ORGAN SIZE; PLOIDIES; PROLIFERATING CELL NUCLEAR ANTIGEN; RATS; RATS, SPRAGUE-DAWLEY; STAT3 TRANSCRIPTION FACTOR; TESTOSTERONE; TIME FACTORS;

EID: 33644818491     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Yen SS: Dehydroepiandrosterone sulfate and longevity: new clues for an old friend. Proc Natl Acad Sci USA 98: 8167-8169, 2001.
2. Mayer D and Forstner K: Impact of dehydroepiandrosterone on hepatocarcinogenesis in the rat (Review). Int J Oncol 25: 1021-1030, 2004.
3. Peters JM, Zhou YC, Ram PA, Lee SST, Gonzalez FJ and Waxman DJ: Peroxisome proliferator activated receptor alpha required for gene induction by dehydroepiandrosterone 3 beta sulfate. Mol Pharmacol 50: 67-74,1996.
4. Rao MS, Subbarao V, Yeldandi AV and Reddy JK: Hepatocarcinogenicity of dehydroepiandrosterone in the rat. Cancer Res 52: 2977-2979,1992.
5. Metzger C, Mayer D, Hoffmann H, Bocker T, Hobe G, Benner A and Bannasch P: Sequential appearance and ultrastructure of amphophilic cell foci, adenomas, and carcinomas in the liver of male and female rats treated with dehydroepiandrosterone. Toxicol Pathol 23: 591-605,1995.
6. Mayer D: DHEA effects on liver. In: DHEA and the Brain. Vol. 1. Morfin R (ed.) Taylor & Francis, London, pp81-100, 2002.
7. Weber E, Moore MA and Bannasch P: Phenotypic modulation of hepatocarcinogenesis and reduction in N-nitrosomorpholine-induced hemangiosarcoma and adrenal lesion development in Sprague-Dawley rats by dehydroepiandrosterone. Carcinogenesis 9: 1191-1195,1988.
8. Mayer D, Forstner K and Kopplow K: Induction and modulation of hepatic preneoplasia and neoplasia in the rat by dehydroepiandrosterone. Toxicol Pathol 31: 1-10,2003.
9. Kalimi M and Regelson W: Dehydroepiandrosterone (DHEA). Biochemical, physiological and clinical aspects. W De Gruyter, Berlin, New York, 2000.
10. Kitamura T, Tanaka K, Morita K, Saito S, Kiba T, Numata K and Sekihara H: Dehydroepiandrosterone (DHEA) facilitates liver regeneration after partial hepatectomy in rats. Life Sci 65: 1747-1756, 1999.
11. Rao MS and Subbarao V: Dehydroepiandrosterone inhibits DNA synthesis of rat hepatocytes induced by partial hepatectomy or mitogen (ciprofibrate). Cell Prolif 30: 1 -5,1997.
12. Ledda-Columbano GM, Pibiri M, Molotzu F, Cossu C, Sanna L, Simula G, Perra A and Columbano A: Induction of hepatocyte proliferation by retinoic acid. Carcinogenesis 25: 2061-2066, 2004.
13. Francavilla A, Carr BI, Azzarone A, Polimero L, Wang Z, van Thiel DH, Subbotin V, Prelich JG and Starzl TE: Hepatocyte proliferation and gene expression induced by triiodothyronine in vivo and in vitro. Hepatology 20: 1237-1241,1994.
14. Ozeki A and Tsukamoto I: Retinoic acid represses the expression of c-fos and c-jun and induces apoptosis in regenerating rat liver after partial hepatectomy. Biochim Biophys Acta 1450: 308-319,1999.
15. Alisi A, Demori I, Spagnolo S, Pierantozzi E, Fugassa E and Leoni S: Thyroid status affects rat liver regeneration after partial hepatectomy by regulating cell cycle and apoptosis. Cell Physiol Biochem 15:69-76,2005.
16. Malik R, Mellor N, Seiden C and Hodgson H: Triiodothyronine enhances the regenerative capacity of the liver following partial hepatectomy. Hepatology 37: 79-86,2003.
17. Higgins GM and Anderson RM: Experimental pathology of the liver I. Restoration of the liver of the white rat following partial surgical removal. Arch Path 12: 186-202,1931.
18. Heinzel W: Ein neues Verfahren zur quantitativen Eiweissbestimmung. Verh Dtsch Ges Inn Med 66: 636-637, 1960.
19. Widnell CC and Tata JR: A procedure for the isolation of enzymatically active rat-liver nuclei. Biochem J 92: 313-317, 1964.
20. Stöhr M, Vogt-Schaden M, Knobloch M, Vogel R and Futterman G: Evaluation of eight fluorochrome combinations for simultaneous DNA-protein flow analyses. Stain Technol 53: 205-215,1978.
21. Harrell FE: Regression Modeling Strategies: With Applications to Linear Models, Logistic Regression, and Survival Analysis. Springer, Berlin, 2001.
22. Taub R: Hepatoprotection via the IL-6/Stat3 pathway. J Clin Invest 112: 978-980,2003.
23. Hobe G, Hillesheim HG, Schör R, Reddersen G, Knappe R, Bannasch P and Mayer D: Sex differences in dehydroepiandrosterone metabolism in the rat: different plasma levels following ingestion of DHEA-supplemented diet and different metabolite patterns in plasma, bile and urine. Hormone Metab Res 26: 326-329,1994.
24. Hobe G, Hillesheim HG, Schör R, Undisz K, Valentin U, Reddersen G, Ritter P, Bannasch P and Mayer D: Studies on the metabolism of DHEA in rats and mice. In: Dehydroepiandrosterone (DHEA). Biochemical, physiological and clinical aspects. Regelson W and Kalimi M (eds.) W de Gruyter, Berlin, pp343-362, 2002.
25. Beier K, Völkl A, Metzger C, Mayer D, Bannasch P and Fahimi HD: Hepatic zonation of the induction of cytochrome P450 IVA, peroxisomal lipid β-oxidation enzymes and peroxisome proliferation in rats treated with dehydroepiandrosterone (DHEA). Evidence of distinct sex differences. Carcinogenesis 18: 1491-1498, 1997.
26. Mayer D, Metzger C, Leonetti P, Beier K, Benner A and Bannasch P: Differential expression of key enzymes of energy metabolism in preneoplastic and neoplastic rat liver lesions induced by N-nitrosomorpholine and dehydroepiandrosterone. Int J Cancer (Pred Oncol) 79: 232-240,1998.
27. Metzger C, Bannasch P and Mayer D: Enhancement and phenotypic modulation of N-nitrosomorpholine-induced hepatocarcinogenesis by dehydroepiandrosterone. Cancer Lett 121: 125-131,1997.
28. Kim RD, Stein GS and Chari RS: Impact of cell swelling on proliferative signal transduction in the liver. J Cell Biochem 83: 56-69,2001.
29. Bannasch P, Klimek F and Mayer D: Early bioenergetic changes in hepatocarcinogenesis: preneoplastic phenotypes mimic responses to insulin and thyroid hormone. J Bioenerg Biomembr 29: 303-313,1997.
30. Trautwein C, Rakemann T, Niehof M, Rose-John S and Manns MP: Acute-phase response factor, increased binding, and target gene transcription during liver regeneration. Gastroenterology 110: 1854-1862, 1996.
31. Cressman DE, Greenbaum LE, De Angelis RA, Ciliberto G, Furth EE, Poli V and Taub R: Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 274: 1379-1383,1996.
32. Straub RH, Konecna L, Hrach S, Rothe G, Kreutz M, Scholmerich J, Falk W and Lang B: Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. J Clin Endocrinol Metab 83: 2012-2017, 1998.
33. Gordon CM, LeBoff MS and Glowacki J: Adrenal and gonadal steroids inhibit IL-6 secretion by human marrow cells. Cytokine 16:178-186,2001.