Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity

Journal of Pineal Research

Volumn 40, Issue 3, 2006, Pages 259-269

  Spadoni, Gilberto ^a   Diamantini, Giuseppe ^a   Bedini, Annalida ^a   Tarzia, Giorgio ^a   Vacondio, Federica ^b   Silva, Claudia ^b   Rivara, Mirko ^b   Mor, Marco ^b   Plazzi, Pier Vincenzo ^b   Zusso, Morena ^c   Franceschini, Davide ^c   Giusti, Pietro ^c  

^a UNIVERSITY OF URBINO   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

2 (N acylaminoethyl)indole; ABTS; Antioxidant; Conjugated dienes; Cytoprotection; Kainate excitotoxicity; Melatonin

Indexed keywords

3 OXO 3 [2 [(5 METHOXY 1H INDOL 2 YL)ETHYL]AMINO]PROPANOIC ACID; CYTOTOXIC AGENT; INDOLE DERIVATIVE; MELATONIN; N [2 (5 CHLORO 1H INDOL 2 YL)ETHYL]ACETAMIDE; N [2 (5 ETHOXY 1H INDOL 2 YL)ETHYL]ACETAMIDE; N [2 (5 FLUORO 1H INDOL 2 YL)ETHYL]ACETAMIDE; N [2 (5 METHOXY 1 METHYL 1H INDOL 2 YL)ETHYL]ACETAMIDE; N [2 (5 METHOXY 1H INDOL 2 YL)ETHYL]ACETAMIDE; N [2 (5 METHOXY 1H INDOL 2 YL)ETHYL]PROPANAMIDE; N [2 (5 METHOXYBENZO[B]THIOPHEN 2 YL)ETHYL]ACETAMIDE; N [2 (5 METHYL 1H INDOL 2 YL)ETHYL]ACETAMIDE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN NERVE CELL; CELL PROTECTION; CELL VIABILITY; CEREBELLUM; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; LIPOPHILICITY; METHYLATION; NEUROPROTECTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIOXIDANTS; CELLS, CULTURED; CEREBELLUM; CYTOPROTECTION; INHIBITORY CONCENTRATION 50; LIPIDS; MELATONIN; NEURONS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTAMINES;

EID: 33644810152     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2005.00309.x     Document Type: Article

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