Mechanisms of relapse in acute leukaemia: Involvement of p53 mutated subclones in disease progression in acute lymphoblastic leukaemia

British Journal of Cancer

Volumn 79, Issue 7-8, 1999, Pages 1151-1157

  Zhu, Y M ^a   Foroni, L ^b   McQuaker, I G ^a   Papaioannou, M ^b   Haynes, A ^a   Russell, H H ^a  

^a NOTTINGHAM CITY HOSPITAL   (United Kingdom)

^b ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

Acute lymphoblastic leukaemia; Acute myeloblastic leukaemia; Clonal selection; Mutations; p53

Indexed keywords

DNA; IMMUNOGLOBULIN HEAVY CHAIN; PROTEIN P53;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER RECURRENCE; CONTROLLED STUDY; DNA SEQUENCE; GENE MUTATION; HUMAN; HUMAN CELL; LYMPHOCYTE CLONE; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD, PRESCHOOL; DISEASE PROGRESSION; DNA MUTATIONAL ANALYSIS; EXONS; FEMALE; GENES, P53; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE, L1; LEUKEMIA, LYMPHOCYTIC, ACUTE, L2; LEUKEMIA, MYELOCYTIC, ACUTE; MALE; MIDDLE AGED; MUTATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; RECURRENCE; SENSITIVITY AND SPECIFICITY;

EID: 0033056305     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690183     Document Type: Article

References (35)

1. Abo J, Inokuchi K, Dan K and Nomura T (1993) p53 and N-ras mutations in two new leukemia cell lines established from a patient with multilineage CD7-positive acute leukemia. Blood 82: 2829-2836
2. Ahuja H, Bar-Eli M, Advani SH, Benchimol S and Cline MJ (1989) Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia. Proc Natl Acad Sci USA 86: 6783-6787
3. Baldini L, Stefano-Fracciolla N, Cro LM, Trecca D, Romitti L, Polli E, Maiolo AT and Neri A (1994) Frequent p53 gene involvement in splenic B-cell leukaemia/lymphomas of possible marginal zone origin. Blood 84: 270-278
4. Beishuizen A, Hahlen K, Hagemeijer A, Verhoeven MAJ, Hooijkaas H, Adriaansen HJ, Wolverstettero ILM, Vanwering ER and Vandongen JJM (1991) Multiple rearranged immunoglobulin genes in childhood acute lymphoblastic leukemia of precursor B-cell origin. Leukemia 5: 657-667
5. Ben-Yehuda D, Krichevsky S, Caspi O et al (1996) Microsatellite instability and p53 mutations in therapy-related leukemia suggest mutator phenotype. Blood 88: 3022-3026
6. Chim JCS, Coyle LA, Yaxley JC, Cole-Sinclair MF, Cannell PK, Hoffbrand VA and Foroni L (1996) The use of IgH fingerprinting and ASO-dependent PCR for the investigation of residual disease (MRD) in ALL. Br J Haematol 92: 104-115
7. Coyle LA, Papaioannou M, Yaxley JS, Chim JS, Attard M, Hoffbrand AV and Foroni L (1996) Molecular analysis of the leukaemic B-cell in adult and childhood acute lymphoblastic leukaemia. Br J Haematol 94: 685-693
8. Diccianni MB, Yu J, Hsiao M, Mukherjee S, Shao L-E and Yu AL (1994) Clinical significance of p53 mutations in relapsed T-cell acute lymphoblastic leukemia. Blood 84: 3105-3112
9. Fenaux P, Junveaux P, Quiquandon I, Lai JL, Pignon JM, Loucheux-Lefebvre MH, Bauters F and Kerckaert JP (1991) p53 gene mutations in myeloid leukemia with 17p monosomy. Blood 78: 1652-1657
10. Fenaux P, Preudhomme C, Quiquandon I, Jonveaux P, Lai JL, Vanrumbeke M, Loucheux-Lefebvre MH, Bauters F, Berger R and Kerchaert JP (1992a) Mutations of the p53 gene in acute myeloid leukaemia. Br J Haematol 80: 178-183
11. Fenaux P, Jonveaux P, Quiquandon I, Preudhomme C, Lai JL, Vanrumbeke M, Loucheux-Lefebvre MH, Bauters F, Berger R and Kerckaert JP (1992b) Mutations of the p53 gene in B-cell lymphoblastic acute leukemia: a report on 60 cases. Leukemia 6: 42-46
12. Gaidano G, Ballerini P, Gong JZ, Inghirami G, Neri A, Newcomb EW, Magrath IT, Knowles DM and Dalla-Favera R1 (1991) p53 mutation in human lymphoid malignancies associated with Burkitt lymphoma and chronic lymphocytic leukemia. Proc Natl Acad Sci USA 88: 5413-5417
13. Hsiao MH, Yu AL, Yeargin J, Ku D and Haas M (1994) Nonhereditary p53 mutations in T-cell acute lymphoblastic leukemia are associated with the relapse phase. Blood 83: 2922-2930
14. Hu G, Zhang W and Deisseroth AB (1992) p53 gene mutations in acute myelogenous leukaemia. Br J Haematol 81: 489-494
15. Jonveaux P and Berger R (1991) Infrequent mutations in the p53 gene in primary human T-cell acute lymphoblastic leukemia. Leukemia 5: 839-840
16. Lane DP and Benchimol S (1990) p53: oncogene or anti-oncogene? Genes & Development 4: 1-8
17. Larder BA, Kohli A, Kellam P, Kemp SD, Kronick M and Henfrey RD (1993) Quantitative detection ot HIV-1 drug resistance mutations by automated DNA sequencing. Nature 365: 671-673
18. Lo Coco F, Gaidano G, Louie DC, Offit K, Chaganti RSK and Dalla-Favera R (1993) p53 mutations are associated with histologic transformation of follicular lymphoma. Blood 82: 2289-2295
19. Lowe SW, Ruley HE, Jacks T and Housman DE (1993) p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74: 957-967
20. Marks DI, Kurz BW, Link MP, Ng E, Shuster JJ, Lauer SJ, Brodsky I and Haines DS (1996) High incidence of potential p53 inactivation in poor outcome childhood acute lymphoblastic leukemia at diagnosis. Blood 87: 1155-1161
21. Martincic D and Whitlock JA (1996) Improved detection of p53 point mutations by dideoxyfingerprinting (ddF). Oncogene 13: 2039-2044
22. Mori N, Wada M, Yokota J, Terada M, Okada M, Teramura M, Masuda M, Hoshino S, Motoji T, Oshimi K and Mizoguchi H (1992) Mutations of the p53 tumour suppressor gene in haematologic neoplasms. Br J Haematol 81: 235-240
23. Murakami Y, Hayashi K and Sekiya T (1991) Detection of aberrations of p53 alleles and the gene transcript in human tumor cell lines by single-strand conformation polymorphism analysis. Cancer Res 51: 3356-3361
24. Nakai H, Misawa SH, Toguchida J, Yandell DW and Ishizaki K (1992) Frequent p53 gene mutations in blast crisis of chronic myelogenous leukemia, especially in myeloid crisis harboring loss of a chromosome. Cancer Res 52: 6588-6593
25. Nishimura S, Asou N, Suzushima H, Okubo T, Fujimoto T, Osato M, Yamasaki H, Lisha L and Takatsuki K (1995) p53 gene mutation and loss of heterozygosity are associated with increased risk of disease progression in adult T-cell leukemia. Leukemia 9: 598-604
26. Papaioannou M, Yaxley JC, Hoffbrand AV and Foroni L (1997) Oligoclonality in acute lymphoblastic leukaemia (ALL): emergence of minor clones rather than change of clonality at relapse in ALL. Br J Haematol 97 (Suppl 1): 202a
27. Sander CA, Yano T, Clark HM, Harris C, Longo DL, Jaffe ES and Raffeld M (1993) p53 mutation is associated with progression in follicular lymphomas. Blood 82: 1994-2004
28. Slingerland JM, Minden MD and Benchimol S (1991) Mutation of the p53 gene in human acute myelogenous leukemia. Blood 77: 1500-1507
29. Sugimoto K, Hirano N, Toyoshima H, Cluiba S, Mano H, Takaku F, Yazaki Y and Hirai H (1993) Mutations of the p53 gene in myelodysplastic syndrome (MDS) and MDS-derived leukemia. Bllood 81: 3022-3026
30. Sugimoto K, Toyoshima H, Sakai R, Miyagawa K, Hagiwara K, Ishikawa F, Takaku F, Yazaki Y and Hirai H (1992) Frequent mutations in the p53 gene in human myeloid leukemia cell lines. Blood 79: 2378-2383
31. Trecca D, Longo L, Biondi A, Cro L, Calori R, Grigani F, Maiolo AT, Pelicci PG and Neri A (1994) Analysis of p53 gene mutations in acute myeloid leukemia. Am J Hematol 46: 304-309
32. Vogelstein B (1990) A deadly inheritance. Nature 348: 681-682
33. Wada H, Asada M, Nakazawa S, Itoh H, Kobayashi Y, Inoue T, Fukumuro K, Chan LC. Sugita K, Hanada R, Akuta N, Kohayashi N and Mizutani S (1994) Clonal expansion of p53 mutant cells in leukemia progression in vitro. Leukemia 8: 53-59
34. Wada M, Bartram CR, Nakamyra H, Hachiyam Chen DL, Borenstein J, Hansen-Hagge TE, Ludwig WD, Reiter A, Mizoguchi H and Koeffler HP (1993) Analysis of p53 mutations in large series of lymphoid hematological malignancies of childhood. Blood 82: 3163-3169
35. Wattel E, Preudhomme C, Hecquet B, Vanrumbeke M, Quesnel B, Dervite I, Morel P and Fenaux P (1994) p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies. Blood 84: 3148-3157