Role of phospholipase C and diacylglyceride lipase pathway in arachidonic acid release and acetylcholine-induced vascular relaxation in rabbit aorta

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 290, Issue 1, 2006, Pages

  Tang, Xin ^a   Edwards, Erik M ^a   Holmes, Blythe B ^a   Falck, John R ^b   Campbell, William B ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Endothelium dependent hyperpolarizing factor; Hydroxyepoxyeicosatrienoic acid; Monoacylglycerol lipase; Phospholipid; Trihydroxyeicosatrienoic acid

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 2,5 PYRROLIDINEDIONE; 1,6 HEXAMETHYLENEDICARBAMIC ACID BIS(CYCLOHEXANONE OXIME) ESTER; ACETYLCHOLINE; ACYLGLYCEROL LIPASE; ARACHIDONIC ACID; FATTY ACID AMIDASE; INDOMETACIN; LIPOPROTEIN LIPASE; METHACHOLINE; N(G) NITROARGININE; PHENYLEPHRINE; PHOSPHOLIPASE C; 1 (6 ((3 METHOXYESTRA 1,3,5(10) TRIEN 17 YL)AMINO)HEXYL) 1H PYRROLE 2,5 DIONE; 1,6 BIS(CYCLOHEXYLOXIMINOCARBONYL)HEXANE; 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYL)HEXANE; 1-(6-((3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL)-1H-PYRROLE-2,5-DIONE; 2 PYRROLIDONE DERIVATIVE; ARACHIDONIC ACID DERIVATIVE; CARBAMIC ACID DERIVATIVE; CYCLOHEXANONE DERIVATIVE; DIAZOMETHANE; DIAZOMETHYLARACHIDONYL KETONE; DRUG DERIVATIVE; ESTRANE DERIVATIVE; ISOENZYME; METHACHOLINE CHLORIDE; PHOSPHOLIPASE A; URB 532;

ANIMAL CELL; AORTA; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE FIBER; SMOOTH MUSCLE RELAXATION; VASCULAR ENDOTHELIUM; VASCULAR RING; VASODILATATION; ANIMAL; BIOSYNTHESIS; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; IN VITRO STUDY; PHYSIOLOGY; SECRETION; THORACIC AORTA;

ACETYLCHOLINE; ANIMALS; AORTA, THORACIC; ARACHIDONIC ACID; ARACHIDONIC ACIDS; CARBAMATES; CELLS, CULTURED; CYCLOHEXANONES; DIAZOMETHANE; ENDOTHELIUM, VASCULAR; ESTRENES; INDOMETHACIN; ISOENZYMES; LIPOPROTEIN LIPASE; METHACHOLINE CHLORIDE; NITROARGININE; PHOSPHOLIPASE C; PHOSPHOLIPASES A; PYRROLIDINONES; RABBITS; VASODILATION;

EID: 33644800772     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00491.2005     Document Type: Article

References (57)

1. Alhenc-Gelas F, Tsai SJ, Callahan KS, Campbell WB, and Johnson AR. Stimulation of prostaglandin formation by vasoactive mediators in cultured human endothelial cells. Prostaglandins 24: 723-742, 1982.
2. Angus JA and Cocks TM. Endothelium-derived relaxing factor. Pharmacol Ther 41: 303-351, 1989.
3. 2 regulation of arachidonic acid mobilization. FEBS Lett 531: 2-6, 2002.
4. Bell RL, Baenziger NL, and Majerus PW. Bradykinin-stimulated release of arachidonate from phosphatidylinositol in mouse fibrosarcoma cells. Prostaglandins 20: 269-274, 1980.
5. Bell RL, Kennerly DA, Stanford N, and Majerus PW. Diglyceride lipase: a pathway for arachidonate release from human platelets. Proc Natl Acad Sci USA 76: 3238-3241, 1979.
6. Billah MM, Lapetina EG, and Cuatrecasas P. Phospholipase A2 and phospholipase C activities of platelets. J Biol Chem 255: 10227-10231, 1980.
7. Blayney L, Gapper P, and Rix C. Identification of phospholipase Cβ isoforms and their location in cultured vascular smooth muscle cells of pig, human and rat. Cardiovasc Res 40: 564-572, 1998.
8. Bligh E and Dyer W. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37: 911, 1959.
9. Breslow MJ. Regulation of adrenal medullary and cortical blood flow. Am J Physiol Heart Circ Physiol 262: H1317-H1330, 1992.
10. Campbell WB, Grebremedhin D, Pratt PF, and Harder DR. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ Res 78: 415-423, 1996.
11. Campbell WB, Spitzbarth N, Gauthier KM, and Pfister SL. 11,12,15-Trihydroxyeicosatrienoic acid mediates acetylcholine-induced relaxations in the rabbit aorta. Am J Physiol Heart Circ Physiol 285: H2648-H2656, 2003.
12. Chau LY and Tai HH. Release of arachidonate from diglyceride in human platelets requires the sequential action of a diglyceride lipase and a monoglyceride lipase. Biochem Biophys Res Commun 100: 1688-1695, 1981.
13. Cowan CL, Palacino JJ, Najibi S, and Cohen RA. Potassium channelmediated relaxation to acetylcholine in rabbit arteries. J Pharmacol Exp Ther 266: 1482-1489, 1993.
14. 2. Biochim Biophys Acta 1488: 40-47, 2000.
15. Dixon JF and Hokin LE. Secretagogue-stimulated phosphatidylinositol breakdown in the exocrine pancreas liberates arachidonic acid, stearic acid, and glycerol by sequential actions of phospholipase C and diglyceride lipase. J Biol Chem 259: 14418-14425, 1984.
16. Edgemond WS, Greenberg MJ, McGinley PJ, Muthian S, Campbell WB, and Hillard CJ. Synthesis and characterization of diazomethylarachidonyl ketone: an irreversible inhibitor of N-arachidonylethanolamine amidohydrolase. J Pharmacol Exp Ther 286: 184-190, 1998.
17. Errasfa M. Characterization of several phospholipase activities and diacylglycerol/2-monoacylglycerol lipases in rat alveolar macrophages. Biochim Biophys Acta 1085: 201-208, 1991.
18. 2 activation by the p38 kinase inhibitor SB203580 in rabbit aortic smooth muscle cells. J Pharmacol Exp Ther 298: 331-338, 2001.
19. Forstermann U, Burgwitz K, and Frolich JC. Effects of nonsteroidal phospholipase inhibitors and glucocorticoids on endothelium-dependent relaxations of rabbit aorta induced by different agents. J Cardiovasc Pharmacol 10: 356-364, 1987.
20. 2+ in relation to generation of acetylcholine-induced endothelium-dependent hyperpolarization in rat mesenteric artery. Br J Pharmacol 120: 1328-1334, 1997.
21. Furchgott RF and Zawadzki JW. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373-376, 1980.
22. Galeotti N, Bartolini A, and Ghelardini C. The phospholipase C-IP3 pathway is involved in muscarinic antinociception. Neuropsychopharmacology 28: 888-897, 2003.
23. Gauthier KM, Spitzbarth N, Edwards EM, and Campbell WB. Apamin-sensitive K currents mediate arachidonic acid-induced relaxations of rabbit aorta. Hypertension 43: 413-419, 2004.
24. 2 and arachidonic acid release in endothelial cells. Atherosclerosis 156: 81-90, 2001.
25. Jaiswal N, Lambrecht G, Mutschler E, Tacke R, and Malik KU. Pharmacological characterization of the vascular muscarinic receptors mediating relaxation and contraction in rabbit aorta. J Pharmacol Exp Ther 258: 842-850, 1991.
26. Jaiswal N and Malik KU. Prostacyclin synthesis elicited by cholinergic agonists is linked to activation of M2a and M2b muscarinic receptors in the rabbit aorta. Prostaglandins 39: 267-280, 1990.
27. Katan M and Williams RL. Phosphoinositide-specific phospholipase C: structural basis for catalysis and regulatory interactions. Semin Cell Dev Biol 8: 287-296, 1997.
28. Kathuria S, Gaetani S, Fegley D, Valino F, Duranti A, Tontini A, Mor M, Tarzia G, La Rana G, Calignano A, Giustino A, Tattoli M, Palmery M, Cuomo V, and Piomelli D. Modulation of anxiety through blockade of anandamide hydrolysis. Nat Med 9: 76-81, 2003.
29. Kawashima K, Watanabe N, Oohata H, Fujimoto K, Suzuki T, Ishizaki Y, Morita I, and Murota S. Synthesis and release of acetylcholine by cultured bovine arterial endothelial cells. Neurosci Lett 119: 156-158, 1990.
30. Moncada S, Gryglewski R, Bunting S, and Vane JR. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263: 663-665, 1976.
31. Moscat J, Herrero C, Garcia-Barreno P, and Municio AM. Phospholipase C-Diglyceride lipase is a major pathway for arachidonic acid release in macrophage. Biochem Biophys Res Commun 141: 367-373, 1986.
32. Nicolle MM, Gallagher M, and McKinney M. Visualization of muscarinic receptor-mediated phosphoinositide turnover in the hippocampus of young and aged, learning-impaired Long Evans rats. Hippocampus 11: 741-746, 2001.
33. Okada S, Shimizu T, and Yokotani K. Brain phospholipase C and diacylglycerol lipase are involved in corticotropin-releasing hormone-induced sympatho-adrenomedullary outflow in rats. Eur J Pharmacol 475: 49-54, 2003.
34. Okazaki T, Sagawa N, Okita JR, Bleasdale JE, MacDonald PC, and Johnston JM. Diacylglycerol metabolism and arachidonic acid release in human fetal membranes and decidua vera. J Biol Chem 256: 7316-7321, 1981.
35. Ozdener F, Dangelmaier C, Ashby B, Kunapuli SP, and Daniel JL. Activation of phospholipase Cγ2 by tyrosine phosphorylation. Mol Pharmacol 62: 672-679, 2002.
36. Parnavelas JG, Kelly W, and Burnstock G. Ultrastructural localization of choline acetyltransferase in vascular endothelial cells in rat brain. Nature 316: 724-725, 1985.
37. Payrastre B, Missy K, Giuriato S, Bodin S, Plantavid M, and Gratacap M. Phosphoinositides: key players in cell signalling, in time and space. Cell Signal 13: 377-387, 2001.
38. Peach MJ, Singer HA, and Loeb AL. Mechanisms of endotheliumdependent vascular smooth muscle relaxation. Biochem Pharmacol 34: 1867-1874, 1985.
39. Pfister SL and Campbell WB. Arachidonic acid and acetylcholineinduced relaxations of rabbit aorta. Hypertension 20: 682-689, 1992.
40. Pfister SL, Schmitz JM, Willerson JT, and Campbell WB. Characterization of arachidonic acid metabolism in Watanabe Heritable Hyperlipidemic (WHHL) and New Zealand White (NZW) rabbit aortas. Prostaglandins 36: 515-531, 1988.
41. Pfister SL, Spitzbarth N, Edgemond W, and Campbell WB. Vasorelaxation by an endothelium-derived metabolite of arachidonic acid. Am J Physiol Heart Circ Physiol 270: H1021-H1030, 1996.
42. Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, and Campbell WB. Identification of 11,14,15- and 11,12,15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta. J Biol Chem 273: 30879-30887, 1998.
43. Prescott SM and Majerus PW. Characterization of 1,2-diacylglycerol hydrolysis in human platelets. Demonstration of an arachidonoyl-monoacylglycerol intermediate. J Biol Chem 258: 764-769, 1983.
44. Quignard JF, Chataigneau T, Corriu C, Edwards G, Weston A, Feletou M, and Vanhoutte PM. Endothelium-dependent hyperpolarization to acetylcholine in carotid artery of guinea pig: role of lipoxygenase. J Cardiovasc Pharmacol 40: 467-477, 2002.
45. Rebecchi MJ and Pentyala SN. Structure, function and control of phosphoinositide-specific phospholipase C. Physiol Rev 80: 1291-1335, 2000.
46. Rhee SG. Regulation of phosphoinositide-specific phospholipase C. Annu Rev Biochem 70: 281-312, 2001.
47. Richards CF, Johnson AR, and Campbell WB. Specific incorporation of 5-hydroxy-6,8,11,14-eicosatetraenoic acid into phosphatidylcholine in human endothelial cells. Biochim Biophys Acta 875: 569-581, 1986.
48. 2 and EETs in the relaxation of bovine coronary arteries to arachidonic acid. Am J Physiol Heart Circ Physiol 264: H327-H335, 1993.
49. 2 by basic fibroblast growth factor via a p42 mitogen-activated protein kinase-dependent phosphorylation pathway in endothelial cells. J Biol Chem 270: 2360-2366, 1995.
50. Singer HA and Peach MJ. Endothelium-dependent relaxation of rabbit aorta. I. Relaxation stimulated by arachidonic acid. J Pharmacol Exp Ther 226: 790-795, 1983.
51. Singer HA and Peach MJ. Endothelium-dependent relaxation of rabbit aorta. II. Inhibition of relaxation stimulated by methacholine and A23187 with antagonists of arachidonic acid metabolism. J Pharmacol Exp Ther 226: 796-801, 1983.
52. 2 enzymes: classification and characterization. Biochim Biophys Acta 1488: 1-19, 2000.
53. Stephenson JA and Summers RJ. Autoradiographic analysis of receptors on vascular endothelium. Eur J Pharmacol 134: 35-43, 1987.
54. Tarzia G, Duranti A, Tontini A, Piersanti G, Mor M, Rivara S, Plazzi PV, Park C, Kathuria S, and Piomelli D. Design, synthesis, and structureactivity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors. J Med Chem 46: 2352-2360, 2003.
55. Walsh CE, Waite BM, Thomas MJ, and DeChatelet LR. Release and metabolism of arachidonic acid in human neutrophils. J Biol Chem 256: 7228-7234, 1981.
56. Whatley RE, Stroud ED, Bunting M, Zinnerman GA, Mclntyre TM, and Prescott SM. Growth-dependent changes in arachidonic acid release from endothelial cells are mediated by protein kinase C and changes in diacylglycerol. J Biol Chem 268: 16130-16138, 1993.
57. 2 and C of human lung; subcellular distribution and substrate selectivity. Biochim Biophys Acta 1003: 189-195, 1989.