Correlation of genetic markers of rejection with biopsy findings following human pancreas transplant

Clinical Transplantation

Volumn 20, Issue 1, 2006, Pages 106-112

  Cashion, Ann ^a,c   Sabek, Omaima ^a,b   Driscoll, Carolyn ^a   Gaber, Lillian ^b   Kotb, Malak ^b   Gaber, Osama ^b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

^c NONE   (United States)

Author keywords

Diabetes; Genetic markers; Kidney pancreas transplantation; Rejection

Indexed keywords

CYCLOSPORIN A; GRANZYME B; HLA DR ANTIGEN; MONOCLONAL ANTIBODY; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PERFORIN; PREDNISONE; RAPAMYCIN; THYMOCYTE ANTIBODY; TSUKUBAENOLIDE;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENE EXPRESSION; GENETIC MARKER; GRAFT REJECTION; HUMAN; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; INSULIN DEPENDENT DIABETES MELLITUS; MALE; PANCREAS BIOPSY; PANCREAS TRANSPLANTATION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE;

ADULT; DIABETES MELLITUS, TYPE 1; FEMALE; GENE EXPRESSION; GRAFT REJECTION; GRANZYMES; HLA-DR ANTIGENS; HUMANS; KIDNEY TRANSPLANTATION; MALE; MEMBRANE GLYCOPROTEINS; PANCREAS TRANSPLANTATION; PILOT PROJECTS; PORE FORMING CYTOTOXIC PROTEINS; PROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SERINE ENDOPEPTIDASES; TRANSPLANTATION, HOMOLOGOUS;

EID: 33644790532     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2005.00450.x     Document Type: Article

References (13)

1. Gruessner AC, Sutherland DE. Pancreas transplant outcomes for United States (US) and non-US cases as reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR) as of June 2004. Clin Transpl 2005: 19: 433.
2. Vasconcellos LM, Schachter AD, Zheng XX et al. Cytotoxic lymphocyte gene expression in peripheral blood leukocytes correlates with rejecting renal allografts. Transplantation 1998: 66: 562.
3. Han D, Xu X, Baidal D et al. Assessment of cytotoxic lymphocyte gene expression in the peripheral blood of human islet allograft recipients: elevation precedes clinical evidence of rejection. Diabetes 2004: 53: 2281.
4. Sabek O, Dorak MT, Kotb M, Gaber AO, Gaber L. Quantitative detection of T-cell activation markers by real-time PCR in renal transplant rejection and correlation with histopathologic evaluation. Transplantation 2002: 74: 701.
5. Oliverira SG, Genzini T, Perosa M et al. Analysis of the inflammatory infiltrate in pancreas allograft biopsies. Transplantation 2002: 74: 81.
6. Papadimitriou JC, Drachenberg CB, Wiland A et al. Histologic grading of acute allograft rejection in pancreas needle biopsy: Correlation to serum enzymes, glycemia, and response to immunosuppressive treatment. Transplantation 1998: 66: 1741.
7. Arakelov A, Lakkis FG. The alloimmune response and effector mechanisms of allograft rejection. Semin Nephrol 2000: 20: 95.
8. Malik ST, Raftery M, Varghese Z, Sweny P, Moorhead JF. Increased expression of Ia (HLA-DR) antigens in rejecting kidneys. Lancet 1984: 2: 577.
9. van Es A, Baldwin WM, Oljans PJ et al. Expression of HLA-DR on T lymphocytes following renal transplantation, and association with graft-rejection episodes and cytomegalovirus infection. Transplantation 1984: 37: 65.
10. Geluk A, van Meijgaarden KE, Schloot NC et al. HLA-DR binding analysis of peptides from islet antigens in IDDM. Diabetes 1998: 47: 1594.
11. Satterwhite T, Chua MS, Hsieh SC et al. Increased expression of cytotoxic effector molecules: Different interpretations for steroid-based and steroid-free immunosuppression. Pediatr Transplant 2003: 7: 53.
12. Han D, Xu X, Pastori RL, Ricordi C, Kenyon NS. Elevation of cytotoxic lymphocyte gene expression is predictive of islet allograft rejection in nonhuman primates. Diabetes 2002: 51: 562.
13. Simon T, Opelz G, Wiesel M, Ott RC, Susal C. Serial peripheral blood perforin and granzyme B gene expression measurements for prediction of acute rejection in kidney graft recipients. Am J Transplant 2003: 3: 1121.