Factor VIIa inhibitors: Improved pharmacokinetic parameters

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 8, 2006, Pages 2243-2246

  Kolesnikov, Aleksandr ^a   Rai, Roopa ^a   Young, Wendy B ^a   Mordenti, Joyce ^a   Liu, Liang ^a   Torkelson, Steven ^a   Shrader, William D ^a   Leahy, Ellen M ^a   Hu, Huiyong ^a   Gjerstad, Erik ^a   Janc, James ^a   Katz, Bradley A ^a   Sprengeler, Paul A ^a  

^a CELERA   (United States)

Author keywords

Amidines; Anticoagulants; Dicarboxylic acids; Factor VIIa; Serine protease inhibitor; Tissue factor

Indexed keywords

BLOOD CLOTTING FACTOR 7A INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL MODEL; CONTROLLED STUDY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG STRUCTURE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTICOAGULANTS; BLOOD COAGULATION; DRUG DESIGN; FACTOR VIIA; HALF-LIFE; HUMANS; MOLECULAR STRUCTURE; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 33644788741     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.01.037     Document Type: Article

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