Treatment failure in patients with ventilator-associated pneumonia

Seminars in Respiratory and Critical Care Medicine

Volumn 27, Issue 1, 2006, Pages 104-113

  Domínguez, Amalia Alcón ^a   Arango, Mauricio Valencia ^a   Torres, Antonio ^a  

^a HOSPITAL CLÍNIC   (Spain)

Author keywords

Nonresolving pneumonia; Treatment failure; Ventilator associated pneumonia

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; CEPHALOSPORIN DERIVATIVE; CILASTATIN PLUS IMIPENEM; CIPROFLOXACIN;

ADULT RESPIRATORY DISTRESS SYNDROME; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTIFICIAL VENTILATION; ATELECTASIS; CATHETER INFECTION; COMORBIDITY; CONGESTIVE HEART FAILURE; DIAGNOSTIC ACCURACY; DRUG TREATMENT FAILURE; EMPYEMA; FEVER; HUMAN; IMMUNE RESPONSE; INTENSIVE CARE UNIT; LUNG ABSCESS; LUNG EDEMA; LUNG EMBOLISM; LUNG HEMORRHAGE; ORGANIZING PNEUMONIA; PLEURA EFFUSION; PRIORITY JOURNAL; PROGNOSIS; REVIEW; SEPSIS; SINUSITIS; SUPERINFECTION; URINARY TRACT INFECTION; VENTILATOR ASSOCIATED PNEUMONIA; WOUND INFECTION;

ANTI-BACTERIAL AGENTS; CROSS INFECTION; DRUG RESISTANCE, BACTERIAL; HUMANS; PNEUMONIA, BACTERIAL; TREATMENT FAILURE; VENTILATORS, MECHANICAL;

EID: 33644687257     PISSN: 10693424     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-933678     Document Type: Review

References (48)

1. Niederman MS, Craven DE. ATS Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005;171:388-416
2. Ioanas M, Ferrer M, Cavalcanti M, et al. Causes and predictors of nonresponse to treatment of intensive care unit-acquired pneumonia. Crit Care Med 2004;32:938-945
3. Kollef MH, Sherman G, Ward S, Fraser V. Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest 1999;115:462-474
4. Alvarez-Lerma F. Modification of empiric antibiotic treatment in patients with pneumonia acquired in the intensive care unit. ICU-Acquired Pneumonia Study Group. Intensive Care Med 1996;22:387-394
5. Luyt C-E, Guerin V, Combes A, et al. Procalcitonin kinetics as a prognostic marker of ventilator-associated pneumonia. Am J Respir Crit Care Med 2005;171:48-53
6. Dupont H, Mentec H, Sollet JP, Bleichner G. Impact of appropriateness of initial antibiotic therapy on the outcome of ventilator-associated pneumonia. Intensive Care Med 2001;27:355-362
7. Mueller EW, Hanes SD, Croce MA, Wood GC, Boucher BA, Fabian TC. Effect from multiple episodes of inadequate empiric antibiotic therapy for ventilator-associated pneumonia on morbidity and mortality. J Trauma 2005;58:94-101
8. Pugin J, Aukenthaler R, Mili N, Janssens JP, Lew PD, Suter PM. Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic "blind" bronchoalveolar lavage fluid. Am Rev Respir Dis 1991;143:1121-1129
9. Luna CM, Blancazo D, Niederman MS, et al. Resolution of ventilator-associated pneumonia: prospective evaluation of the clinical pulmonary infection store as an early clinical predictor of outcome. Crit Care Med 2003;31:676-682
10. Vidaur L, Gualis B, Rodríguez A, et al. Clinical resolution in patients with suspicion of ventilator-associated pneumonia: a cohort study comparing patients with and without acute respiratory distress syndrome. Crit Care Med 2005;33:1248-1253
11. Montravers P, Fagon JY, Chastre J, et al. Follow-up protected specimen brushes to asses treatment in nosocomial pneumonia. Am Rev Respir Dis 1993;147:38-44
12. Dennesen PJW, van der Ven A, Kessels A, Ramsay G, Bonten M. Resolution of infectious parameters alter antimicrobial therapy in patients with ventilator-associated pneumonia. Am J Respir Crit Care Med 2001;163:1371-1375
13. Povoa P, Coelho L, Almeida E, et al. C-reactive protein as a marker of ventilator-associated pneumonia resolution: a pilot study. Eur Respir J 2005;25:804-812
14. Trouillet JL, Chastre J, Vuagnat A, et al. Ventilator-associated pneumonia caused by potentially drug-resistant bacteria. Am J Respir Crit Care Med 1998;157:531-539
15. Iregui M, Ward S, Sherman G, Fraser VJ, Kollef MH. Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest 2002;122:262-268
16. Garnacho-Montero J, Garcia-Garmendia JL, Barrero-Almodovar A, Jiménez-Jiménez FJ, Perez-Paredes C, Ortiz-Leyba C. Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis. Crit Care Med 2003;31:2742-2751
17. Rello J, Sa-Borges M, Correa H, Leal SR, Baraibar J. Variations in etiology of ventilator-associated pneumonia across four treatment sites: implications for antimicrobial prescribing practices. Am J Respir Crit Care Med 1999;160:608-613
18. Petri MG, König J, Moecke HP, et al. Epidemiology of invasive mycosis in ICU patients: a prospective multicenter study in 435 non-neutropenic patients. Intensive Care Med 1997;23:317-325
19. Daubin C, Vincent S, Vabret A, et al. Nosocomial viral ventilator-associated pneumonia in the intensive care unit: a prospective cohort study. Intensive Care Med 2005;31:1116-1122
20. Fink MP, Snydman DR, Niederman MS, et al. Treatment of severe pneumonia in hospitalized patients: results of a multicenter, randomized, double-blind trial comparing intravenous ciprofloxacin with imipenem-cilastin. Antimicrob Agents Chemother 1994;38:547-557
21. Chow JW, Fine MJ, Sales DM, et al. Enterobacter bacteremia: clinical factors and emergence of resistance during treatment. Ann Intern Med 1991;115:585-590
22. Combes A, Figliolini C, Trouillet J-L, et al. Factors predicting ventilator-associated pneumonia recurrence. Crit Care Med 2003;31:1102-1107
23. Meduri GU, Mauldin GL, Wunderik RG, et al. Causes of fever and pulmonary densities in patients with clinical manifestations of ventilator-associated pneumonia. Chest 1994;106:221-235
24. Marik PE. Fever in the ICU. Chest 2000;117:855-869
25. Bert F, Lambert-Zechovsky N. Sinusitis in mechanically ventilated patients and its role in the pathogenesis of nosocomial pneumonia. Eur J Clin Microbiol Infect Dis 1996;15:533-544
26. Rouby JJ, Laurent P, Gosnach M, et al. Risk factors and clinical relevance of nosocomial maxillary sinusitis in the critically ill. Am J Respir Crit Care Med 1994;150:776-783
27. Westergren V, Berg S, Lundgren J. Ultrasonographic bedside evaluation of maxillary sinus disease in mechanically ventilated patients. Intensive Care Med 1997;23:393-398
28. Holzapfel L, Chastang C, Demingeon G, Bohe J, Piralla B, Coupry A. A randomized study assessing the systematic search for maxillary sinusitis in nasotracheally mechanically ventilated patients: influence of nosocomial maxillary sinusitis on the occurrence of ventilator-associated pneumonia. Am J Respir Crit Care Med 1999;159:695-701
29. Winer-Muram HT, Rubin SA, Ellis JV, et al. Pneumonia and ARDS in patients receiving mechanical ventilation: diagnostic accuracy of chest radiography. Radiology 1993;188:479-485
30. Fagon JY, Chastre J, Hance AJ, Domart Y, Trouillet JL, Gibert C. Evaluation of clinical judgment in the identification and treatment of nosocomial pneumonia in ventilated patients. Chest 1993;103:547-553
31. Crump JA, Collignon PJ. Intravascular catheter-associated infections. Eur J Clin Microbiol Infect Dis 2000;19:1-8
32. Richards MJ, Edwards JR, Culver DH, Gaynes RP, and the National Nosocomial Infections Surveillance System. Nosocomial infections in medical intensive care units in the United States. Crit Care Med 1999;27:887-892
33. Barie PS, Fischer E. Acute acalculous cholecystitis. J Am Coll Surg 1995;180:232-244
34. Shields CJ, Winter DC, Redmond HP. Lung injury in acute pancreatitis: mechanisms, prevention and therapy. Curr Opin Crit Care 2002;8:158-163
35. Kyne L, Hamel MB, Polavaram R, Nelly CP. Health care costs and mortality associated with nosocomial diarrhea due to Clostridium difficile. Clin Infect Dis 2002;34:346-353
36. Nakos G, Tsangaris H, Liokatis S, Kitsiouli E, Lekka ME. Ventilator-associated pneumonia and atelectasis: evaluation through bronchoalveolar lavage fluid analysis. Intensive Care Med 2003;29:555-556
37. Pistolesi M, Miniati M. Imaging techniques in treatment algorithms of pulmonary embolism. Eur Respir J Suppl 2002;35:S28-S39
38. Raño A, Agusti C, Jimenez P, et al. Pulmonary infiltrates in non-HIV immunocompromised patients: a diagnostic approach using non-invasive and bronchoscopic procedures. Thorax 2001;56:379-387
39. Cordier JF. Organising pneumonia. Thorax 2000;55:318-328
40. Delclaux C, Roupie E, Blot F, Brochard L, Lemaire F, Brun-Buisson C. Lower respiratory tract colonization and infection during severe acute respiratory distress syndrome: incidence and diagnosis. Am J Respir Crit Care Med 1997;156:1092-1098
41. Jordan S, Mitchell JA, Quinlan GJ, Goldstraw P, Evans TW. The pathogenesis of lung injury following pulmonary resection. Eur Respir J 2000;15:790-799
42. Wunderink RG. Ventilator associated-pneumonia: failure to respond to antibiotic therapy. Clin Chest Med 1995;16:173-193
43. Mason CM, Nelson S. Normal host defences and impairments associated with the delayed resolution of pneumonia. Semin Respir Infect 1992;7:243-255
44. Marshall J, Sweeney D. Microbial infection and the septic response in critical surgical illness: sepsis, not infection, determines outcome. Arch Surg 1990;125:17-22
45. Crouch Brewer S, Wunderink RG, Jones CB, Leeper KV. Ventilator-associated pneumonia due to Pseudomonas aeruginosa. Chest 1996;109:1019-1029
46. Wu CL, Yang DI, Wang NY, Kuo HT, Chen PZ. Quantitative culture of endotracheal aspirates in the diagnosis of ventilator-associated pneumonia in patients with treatment failure. Chest 2002;122:662-668
47. O'Brien JD, Ettinger NA, Shevlin D, Kollef MH. Safety and yield of transbronchial biopsy in mechanically ventilated patients. Crit Care Med 1997;25:440-446
48. Bulpa PA, Dive AM, Mertens L, et al. Combined bronchoalveolar lavage and transbronchial lung biopsy: safety and yield in ventilated patients. Eur Respir J 2003;21:489-494