The impact of dydrogesterone supplementation on serum cytokine profile in women with threatened abortion

American Journal of Reproductive Immunology

Volumn 55, Issue 2, 2006, Pages 115-121

  Kalinka, Jarosław ^a   Radwan, Michał ^b  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b POLISH MOTHER S MEMORIAL HOSPITAL RESEARCH INSTITUTE   (Poland)

Author keywords

Cytokines; Dydrogesterone; Early pregnancy; Threatened abortion

Indexed keywords

CYTOKINE; DYDROGESTERONE; INTERLEUKIN 10; INTERLEUKIN 12; PROGESTERONE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HORMONAL THERAPY; HORMONE ACTION; HUMAN; IMMINENT ABORTION; PREGNANCY; PRIORITY JOURNAL; TH1 CELL; TH2 CELL; THERAPY EFFECT;

ABORTION, THREATENED; CASE-CONTROL STUDIES; CYTOKINES; DYDROGESTERONE; FEMALE; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME;

EID: 33644676884     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2005.00333.x     Document Type: Article

References (29)

1. Nybo Andersen AM, Wohlfahrt J, Christens P, Olsen J, Melbye M: Maternal age and fetal loss: Population based register linkage study. BMJ. 2000; 320: 1708-1712.
2. De la Rochebrochard E, Thonneau P: Paternal age and maternal age are risk factors for miscarriage; results of a multicentre European study. Hum Reprod 2002; 17: 1649-1656.
3. Gleicher N, et al. (ed.): Principles and Practice of Medical Therapy in Pregnancy. Stamford, CT, Appleton & Lange, 1998, pp 511-521.
4. Ng SC, Gilman-Sachs A, Thaker P, Beaman KD, Beer AE, Kwak-Kim J: Expression of intracellular Th1 and Th2 cytokines in women with recurrent spontaneous abortion, implantation failures after IVF/ET or normal pregnancy. Am J Reprod Immunol 2002; 48: 77-86.
5. Makhseed M, Raghupathy R, Azizieh F, Farhat R, Hassan N, Bandar A: Circulating cytokines and CD30 in normal human pregnancy and recurrent spontaneous abortions. Hum Reprod 2000; 15: 2011-2017.
6. Raghupathy R: Th1-type immunity is incompatible with successful pregnancy. Immunol Today 1997; 18: 478-482.
7. Romagnani S: Human ThR and Th2 subsets: regulation of differentiation and role in protection and immunopathology. Int Arch Allergy Immunol 1992; 98: 279-285.
8. Hayakawa S, Nagai N, Kanaeda T, Karasaki-Suzuki M, Ishii M, Chishima F, Satoh K: Interleukin-12 augments cytolytic activity of peripheral and decidual lymphocytes against choriocarcinoma cell lines and primary culture human placental trophoblasts. Am J Reprod Immunol 1999; 41: 320-329.
9. Szereday L, Varga P, Szekeres-Bartho J: Cytokine production in pregnancy. Am J Reprod Immunol 1997; 38: 418-422.
10. Chaouat G: Innately moving away from the TH1/Th2 paradigm in pregnancy. Clin Exp Immunol 2003; 131: 393-395.
11. Sacks GP, Redman CW, Sargent IL: Monocytes are primed to produce the TH1 type cytokine IL-12 in normal human pregnancy: An intracellular flow cytometric analysis of peripheral blood mononuclear cell. Clin Exp Immunol 2003; 131: 490-497.
12. Piccinni MP, Giudizi MG, Biagiotti R, Beloni L, Giannarini L, Sampognaro S, Parronchi P, Manetti R, Annunziato F, Livi C, Romagnani S, Maggi E: Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established T cell clones. J Immunol 1995; 155: 128-133.
13. Choi BC, Polgar K, Xiao L, Hill JA: Progesterone inhibits in vitro embryotoxic Th1 cytokine production to trophoblast in women with recurrent pregnancy loss. Hum Reprod 2000; 15 (Suppl. 1): 46-59.
14. Szekeres-Bartho J, Kilar F, Falkay G, Csernus V, Torok A, Pacsa AS: Progesterone-treated lymphocytes of healthy pregnant women release a factor inhibiting cytotoxicity and prostaglandin synthesis. Am J Reprod Immunol Microbiol 1985; 9: 15-19.
15. Szekeres-Bartho J, Autran B, Debre P, Andreu G, Denver L, Chaouat G: Immunoregulatory effects of a suppressor factor from healthy pregnant women's lymphocytes after progesterone induction. Cell Immunol 1989; 122: 281-294.
16. Szekeres-Bartho J, Par G, Dombay Gy, Smart YC, Volgyi Z: The anti-abortive effect of PIBF in mice is manifested by modulating NK activity. Cell Immunol 1997; 177: 194-199.
17. Szekeres-Bartho J, Par G, Szereday L, Smart CY, Achacz I: Progesterone and non-specific immunological mechanisms in pregnancy. Am J Reprod Immunol 1997; 38: 176-182.
18. Szekeres-Bartho J, Szekeres Gy, Debre P, Autran B, Chaouat G: Reactivity of lymphocytes to a progesterone receptor-specific monoclonal antibody. Cell Immunol 1990; 125: 273-283.
19. Kalinka J, Szekeres-Bartho J: The impact of dydrogesterone supplementation on hormonal profile and progesterone-induced blocking factor concentrations in women with threatened abortion. Am J Reprod Immunol 2005; 53: 166-171.
20. Szekeres-Bartho J, Wegmann TG: A progesterone-dependent immunomodulatory protein alters the Th1/Th2 balance. J Reprod Immunol 1996; 31: 81-95.
21. Paradisi R, Maldini-Casadei M, Boni P, Busacchi P, Porcu E, Venturoli S: T-helper 2-cytokine levels in women with threatened abortion. Eur J Obstet Gynecol Reprod Biol 2003; 111: 43-49.
22. Paradisi R, Porcu E, Venturoli S, Maldini-Casadei M, Boni P: Maternal serum levels of pro-inflammatory cytokines in missed and threatened abortion. Am J Reprod Immunol 2003; 50: 302-308.
23. Makhseed M, Raghupathy R, Azizieh F, Omu A, Al-Shamali E, Ashkanani L: Th1 and Th2 cytokine profile in recurrent aborters with successful pregnancy and with subsequent abortions. Hum Reprod 2002; 17: 1669-1670.
24. Raghupathy R, Makhseed M, Azizieh F, Omu A, Gupta M, Farhat R: Cytokine production by maternal lymphocytes during normal human pregnancy and in unexplained recurrent spontaneous abortion. Hum Reprod 2000; 15: 713-718.
25. Gucer F, Balkanli-Kaplan P, Yuksel M, Sayin NC, Yuce MA, Yardim T: Maternal serum levels of tumor necrosis factor-alpha and interleukin-2 receptor in threatened abortion: A comparison with normal and pathologic pregnancies. Fertil Steril 2001; 76: 707-711.
26. Blois SM, Joachim R, Kandil J, Margni R, Tometten M, Klapp BF, Arck PC: Depletion of CD8+ cells abolishes the pregnancy protective effect of progesterone substitution with dydrogesterone in mice by altering the Th1/Th2 cytokine profile. J Immunol 2004; 172: 5893-5899.
27. Sotiriadis A, Papatheodorou S, Makrydimas G: Threatened miscarriage: evaluation and management. BMJ 2004; 329: 152-155.
28. Oates-Whitehead RM, Haas DM, Carrier JA: Progestogen for preventing miscarriage. Cochrane Database Syst Rev 2003; 4: CD003511.
29. Chaouat G, Ledee-Bataille N, Dubanchet S, Zourbas S, Sandra O, Martal J: TH1/TH2 paradigm in pregnancy: Paradigm lost? Cytokines in pregnancy/ early abortion: Reexamining the TH1/TH2 paradigm. Int Arch Allergy Immunol 2004; 134: 93-119.