Granulocyte colony-stimulating factor-induced blood stem cell mobilisation in patients with chronic heart failure: Feasibility, safety and effects on exercise tolerance and cardiac function

Basic Research in Cardiology

Volumn 101, Issue 1, 2006, Pages 78-86

  Hüttmann, Andreas ^a   Dührsen, Ulrich ^a   Stypmann, Jö ^b   Noppeney, Richard ^a   Nückel, Holger ^a   Neumann, Till ^a   Gutersohn, Achim ^a   Nikol, Sigrid ^b   Erbel, Raimund ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Blood stem cells; Coronary artery disease; Dilated cardiomyopathy; Granulocyte colony stimulating factor; Heart failure

Indexed keywords

ALKALINE PHOSPHATASE; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CREATININE; DIGITALIS; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; ENOXAPARIN; GAMMA GLUTAMYLTRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LACTATE DEHYDROGENASE; NITRATE; PARACETAMOL; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; URIC ACID;

ADULT; AGED; ANGINA PECTORIS; ARTICLE; BONE PAIN; CD34 SELECTION; CELL COUNT; CELL CYCLE; CLINICAL ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG FATALITY; DRUG SAFETY; DYSPNEA; ECHOCARDIOGRAPHY; EXERCISE TOLERANCE; EYE BURNING; FEASIBILITY STUDY; HEART ARRHYTHMIA; HEART FAILURE; HEART VENTRICLE FIBRILLATION; HUMAN; ISCHEMIC HEART DISEASE; LEUKOCYTOSIS; MALE; MYOCARDIAL DISEASE; NIGHT SWEAT; PHYSICAL PERFORMANCE; RISK ASSESSMENT; STATISTICAL SIGNIFICANCE; STEM CELL MOBILIZATION; THROMBOCYTE DYSFUNCTION; THROMBOSIS; WALKING;

AGED; EXERCISE TEST; EXERCISE TOLERANCE; GRANULOCYTE COLONY-STIMULATING FACTOR; HEART FAILURE, CONGESTIVE; HEMATOPOIETIC STEM CELL MOBILIZATION; HUMANS; LEUKOCYTE COUNT; MALE; MIDDLE AGED; PATIENT COMPLIANCE; TREATMENT OUTCOME;

EID: 33644657975     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00395-005-0556-1     Document Type: Article

References (34)

1. Balsam LB, Wagers AJ, Christensen JL, Kofidis T, Weissman IL, Robbins RC (2004) Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature 428:668-673
2. Bhatia M, Bonnet D, Murdoch B, Gan OI, Dick JE (1998) A newly discovered class of human hematopoietic cells with SCID-repopulating activity. Nat Med 4:1038-1045
3. Dührsen U, Villeval JL, Boyd J, Kannourakis G, Morstyn G, Metcalf D (1988) Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients. Blood 72:2074-2081
4. Dührsen U, Sheridan WP (1994) G-CSF: Role in bone marrow and peripheral blood stem cell transplantation. In: Mertelsmann R, Herrmann F (eds) Hematopoietic growth factors in clinical applications. Marcel Dekker Inc, New York, pp 241-256
5. Erbel R, Zotz R, Henkel B, Schreiner G, Steuernagel C (1987) Echocardiography for follow up studies after intervention. In: Roelandt J (ed) Digital techniques in echocardiography. Martinus Nijhoff Publishers, Dordrecht, pp 133-154
6. Guyatt GH, Sullivan MJ, Thompson PJ, Fallen EL, Pugsley SO, Taylor DW et al. (1985) The 6-minute walk: A new measure of exercise capacity in patients with chronic heart failure. Can Med Assoc J 132:919-923
7. Harada M, Qin Y, Takano H, Minamino T, Zou Y, Toko H et al (2005) G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nat Med 11:305-311
8. Hill JM, Paul JD, Powell TM, McCoy JP, Dunbar CE, Horne M et al. (2003) Efficacy and risk of granulocyte colony stimulating factor administration in patients with severe coronary artery disease. Circulation 108 (suppl IV):478
9. Hüttmann A, Li CL, Dührsen U (2003) Bone marrow-derived stem cells and "plasticity". Ann Hematol 82:599-604
10. Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR et al. (2002) Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418:41-49
11. Kang HJ, Kim HS, Zhang SY, Park KW, Cho HJ, Koo BK et al. (2004) Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte- colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: The MAGIC cell randomised clinical trial. Lancet 363:751-756
12. Kawada H, Fujita J, Kinjo K, Matsuzaki Y, Tsuma M, Miyatake H et al. (2004) Nonhematopoietic mesenchymal stem cells can be mobilized and differentiate into cardiomyocytes after myocardial infarction. Blood 104:3581-3587
13. Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R et al. (2001) Multi-organ, multi-lineage engraftment by a single bone marrowderived stem cell. Cell 105:369-377
14. Kuethe F, Figulla HR, Voth M, Richartz BM, Opfermann T, Sayer HG et al. (2004) Mobilization of stem cells by granulocyte colony-stimulating factor for the regeneration of myocardial tissue after myocardial infarction. Dtsch Med Wochenschr 129:424-428
15. Laham RJ, Oettgen P (2003) Bone marrow transplantation for the heart: fact or fiction? Lancet 361:11-12
16. Lapidot T, Petit I (2002) Current understanding of stem cell mobilization: The roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells. Exp Hematol 30:973-981
17. Matsubara H (2004) Risk to the coronary arteries of intracoronary stem cell infusion and G-CSF cytokine therapy. Lancet 363:746-747
18. Morstyn G, Campbell L, Souza LM, Alton NK, Keech J, Green M et al (1988) Effect of granulocyte colony stimulating factor on neutropenia induced by cytotoxic chemotherapy. Lancet 1 (8587):667-672
19. Murry CE, Soonpaa MH, Reinecke H, Nakajima H, Nakajima HO, Rubart M et al. (2004) Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 428:664-668
20. Norol F, Merlet P, Isnard R, Sebillon P, Bonnet N, Cailliot C et al. (2003) Influence of mobilized stem cells on myocardial infarct repair in a nonhuman primate model. Blood 102:4361-4368
21. Nygren JM, Jovinge S, Breitbach M, Säwén P, Röll W, Hescheler J et al. (2004) Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat Med 10:494-501
22. Ohtsuka M, Takano H, Zou Y, Toko H, Akazawa H, Qin Y et al. (2004) Cytokine therapy prevents left ventricular remodeling and dysfunction after myocardial infarction through neovascularization. FASEB J 18:851-853
23. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B et al. (2001) Bone marrow cells regenerate infarcted myocardium. Nature 410:701-705
24. Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F et al. (2001) Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci USA 98:10344-10349
25. Orlic D, Arai AE, Sheikh FH, Agyeman KO, McGehee J, Hoyt RF et al. (2002) Cytokine mobilized CD34+ cells do not benefit rhesus monkeys following induced myocardial infarction. Blood 100:28a-29a
26. Perin EC, Dohmann HF, Borojevic R, Silva SA, Sousa AL, Mesquita CT et al. (2003) Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 107:2294-2302
27. Schüchinger V, Assmus B, Britten MB, Honold J, Lehmann R, Teupe C et al. (2004) Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: Final oneyear results of the TOPCARE-AMI Trial. J Am Coll Cardiol 44:1690-1699
28. Stamm C, Westphal B, Kleine HD, Petzsch M, Kittner C, Klinge H et al. (2003) Autologous bone-marrow stemcell transplantation for myocardial regeneration. Lancet 361:45-46
29. Strauer BE, Brehm M, Zeus T, Köstering M, Hernandez A, Sorg RV et al. (2002) Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 106:1913-1918
30. Terrovitis J, Charitos C, Dolou P, Papalois A, Eleftheriou A, Tsolakis E et al. (2004) No effect of stem cell mobilization with GM-CSF on infarct size and left ventricular function in experimental acute myocardial infarction. Basic Res Cardiol 99:241-246
31. Tögel F, Isaac J, Westenfelder C (2004) Hematopoietic stem cell mobilization associated granulocytosis severely worsens acute renal failure. J Am Soc Nephrol 15:1261-1267
32. Tomita S, Ishida M, Nakatani T, Fukuhara S, Hisashi Y, Ohtsu Y et al. (2004) Bone marrow is a source of regenerated cardiomyocytes in doxorubic ininduced cardiomyopathy and granulocyte colony-stimulating factor enhances migration of bone marrow cells and attenuates cardiotoxicity of doxorubicin under electron microscopy. J Heart Lung Transplant 23:577-584
33. Tse HF, Kwong YL, Chan JK, Lo G, Ho CL, Lau CP (2003) Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Lancet 361:47-49
34. Wollert KC, Meyer GP, Lotz J, Ringes-Lichtenberg S, Lippolt P, Breidenbach C et al. (2004) Intracoronary autologous bone-marrow cell transfer after myocardial infarction: The BOOST randomised controlled clinical trial. Lancet 364:141-148