Chronic lymphocytic leukemia patients with highly stable and indolent disease show distinctive phenotypic and genotypic features

Blood

Volumn 102, Issue 3, 2003, Pages 1035-1041

  Guarini, Anna ^b   Gaidano, Gianluca ^b   Mauro, Francesca Romana ^b   Capello, Daniela ^b   Mancini, Francesca ^b   De Propris, Maria Stefania ^b   Mancini, Marco ^b   Orsini, Enrica ^b   Gentile, Massimo ^b   Breccia, Massimo ^b   Cuneo, Antonio ^b   Castoldi, Gianluigi ^b   Foa, Robert ^a  

^a Sezione di Biologia   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; IMMUNOGLOBULIN HEAVY CHAIN; PROTEIN P53;

ADULT; AGED; ANTIBIOTIC THERAPY; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; CHROMOSOME 11Q; CHROMOSOME 17P; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE DELETION; GENE ISOLATION; GENE MUTATION; GENOTYPE; HUMAN; IMMUNOPHENOTYPING; KARYOTYPE; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN STABILITY; REPRODUCIBILITY; TREATMENT INDICATION; TREATMENT OUTCOME; VH1 69 GENE; VH3 21 GENE;

EID: 0042744791     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-12-3639     Document Type: Article

References (44)

1. Catovsky D, Foa R. The Lymphoid Leukaemias. London, England: Butterworths; 1990:73-112.
2. Foa R, Guarini A. Biology of chronic lymphocytic leukemia: ASCO Educational Book. Alexandria, VA: American Society of Clinical Oncology. 1999; 178-183.
3. Rozman C, Montserrat E. Chronic lymphocytic leukemia. N Engl J Med. 1995;333:1052-1057.
4. Rai KR, Savitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS. Clinical staging of chronic lymphocytic leukemia. Blood. 1975;46: 219-234.
5. Binet J-L, Leporrier M, Dighiero G, et al. A clinical staging system for chronic lymphocytic leukemia. Cancer. 1977;40:855-864.
6. Bennett JM, Catovsky D, Daniel MT, et al. The French-American-British (FAB) Cooperative Group: proposals for the classification of chronic (mature) B and T lymphoid leukemias. J Clin Pathol. 1989;42:567-584.
7. Vallespi T, Montserrat E, Sanz MA. Chronic lymphocytic leukaemia: prognostic value of lymphocyte morphological subtypes: a multivariate survival analysis in 146 patients. Br J Haematol. 1991;77:478-485.
8. Criel A, Verhoef G, Vlietinck R, et al. Further characterization of morphologically defined typical and atypical CLL: a clinical, immunophehotipic, cytogenetic and prognostic study on 390 cases. Br J Haematol 1997;97:383-391.
9. Cordone I, Masi S, Mauro FR, et al. p53 expression in B-cell chronic lymphocytic leukemia: a marker of disease progression and poor prognosis. Blood. 1998;91:4342-4349.
10. Döhner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med. 2000;343: 1910-1916.
11. Damle RN, Wasil T, Fais F, et al. Ig V gene status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukaemia. Blood. 1999;94:1840-1847.
12. Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig VH genes associated with a more aggressive form of chronic lymphocytic leukaemia. Blood. 1999;94:1848-1854.
13. Ibrahim S, Keating M, O'Brien S, et al. CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia. Blood. 2001; 98:181-186.
14. Hamblin TJ, Orchard JA, Ibbotson RE, et al. CD38 expression and immunoglobulin variable region mutations are indipendent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease. Blood. 2002;99:1023-1029.
15. Chronic lymphocytic leukemia: recommendations for diagnosis staging, and response criteria: International Workshop on Chronic Lymphocytic Leukemia. Ann Inter Med. 1989;110:236-238.
16. Fais F, Ghiotto F, Hashimoto S, et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest. 1998;102:1515-1525.
17. Kuppers R, Zhao M, Hansmann M-L, Rajewsky K. Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J. 1993; 12:4955-4967.
18. Kuppers R, Zhao M, Rajewsky K, Hansmann ML. Detection of clonal B cell populations in paraffin-embedded tissues by polymerase chain reaction. Am J Pathol. 1993;143:230-239.
19. Migliazza A, Martinotti S, Chen W, et al. Frequent somatic hypermutation of the 5′ noncoding region of the BCL-6 gene in B-cell lymphoma. Proc Natl Acad Sci U S A. 1995;92:12520-12524.
20. Gaidano G, Ballerini P, Gong JZ, et al. p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 1991; 88:5413-5417.
21. Cuneo A, Bigoni R, Negrini M, et al. Cytogenetic and interphase cytogenetic characterization of atypical chronic lymphocytic leukemia carrying BCL1 translocation. Cancer Res. 1997;15:1144-1150.
22. ISCN 1995: An International System for Human Cytogenetic Nomenclature. Mitelman F, ed. Basel, Switzerland: S Karger; 1995.
23. Zhang Y, Matthiesen P, Harder S, et al. A 3-cM commonly deleted region in 6q21 in leukemias and lymphomas delineated by fluorescence in situ hybridation. Genes Chromosomes Cancer. 2000;27:52-58.
24. Leroux D, Monteil M, Sotto JJ, et al. Variant t(2; 18) translocation in a follicular lymphoma. Br J Haematol. 1990;75:290-292.
25. Tashiro S, Takechi M, Asou H, et al. Cytogenetic 2;18 and 18;22 translocation in chronic lymphocytic leukemia with juxtaposition of bcl-2 and immunoglobulin light chain genes. Oncogene. 1992;7:573-577.
26. H3-21 genes characterize a new subset of chronic lymphocytic leukemia. Blood. 2002;99:2262-2264.
27. Brezinschek HP, Brezinschek RI, Dorner T, Lipsky PE. Similar characteristics of the CDR3 of V(H)1-69/DP-10 rearrangement in normal human peripheral blood and chronic lymphocytic leukaemia B cells. Br J Haematol. 1998; 102:516-521.
28. Capello D, Fais F, Vivenza D, et al. Identification of three subgroups of B cell chronic lymphocytic leukemia based upon mutations of BCL-6 and IgV genes. Leukemia. 2000;14:811-815.
29. Caligaris-Cappio F, Hamblin TJ. B-cell chronic lymphocytic leukemia: a bird of a different feather. J Clin Oncol. 1999;17:399-408.
30. Foa R, Catovsky D, Brozovic M, et al. Clinical staging and immunological findings in chronic lymphocytic leukemia. Cancer. 1979;44:483-487.
31. Lauria F, Foa R, Mantovani V, Fierro MT, Catovsky D, Tura S. T-cell functional abnormality in B-chronic lymphocytic leukaemia: evidence of a defect of the T-helper subset. Br J Haematol. 1983;54:277-283.
32. Scriver S, Kaminski ER, Demaine A, Prentice AG. Analysis of the expression of critical activation/interaction markers on peripheral blood T cells in B-cell chronic lymphocytic leukaemia: evidence of immune dysregulation. Br J Haematol. 2001; 112:959-964.
33. Morrison VA. The infectious complications of chronic lymphocyte leukemia. Semin Oncol. 1998;25:98-106.
34. Reza Rezvany M, Jeddi-Tehrani M, Rabbani H, et al. Autologous T lymphocytes recognize the tumor-derived immunoglobulin VH-CDR3 region in patients with B-cell chronic lymphocytic leukaemia. Br J Haematol. 2000;11:230-238.
35. Mauro FR, Foa R, Cerretti R, et al. Autoimmune hemolytic anemia in chronic lymphocytic leukemia: clinical, therapeutic and prognostic features. Blood. 2000;95:2786-2792.
36. Mauro FM, Gentile M, Mancini F, et al. Prognostic significance of lymphocyte morphology in patients with advanced chronic lymphocytic leukemia treated with first line therapy of fludarabine + prednisone. Haematologica. 2002;87:602-608.
37. Juliusson G, Oscier DG, Fitchett M, et al. Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities. N Engl J Med. 1990;323:720-724.
38. Oscier DG, Gardiner AC, Mould SJ, et al. Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors. Blood. 2002;100: 1177-1184.
39. H mutation in chronic lymphocytic leukemia. Blood. 2002;100: 1404-1409.
40. H mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia. Blood. 2002;100:1410-1416.
41. Pasqualucci L, Neri A, Baldini L, Dalla-Favera R, Migliazza A. BCL-6 mutations are associated with immunoglobulin variable heavy chain mutations in B-cell chronic lymphocytic leukemia. Cancer Res. 2000;60:5644-5648.
42. Sahota S, Davis Z, Hamblin TJ, Stevenson FK. Somatic mutation of bcl-6 genes can occur in the absence of Vh mutations in chronic lymphocytic leukemia. Blood. 2000;95:3534-3540.
43. Dighiero G, Maloum K, Desablens B, et al. Chlorambucil in indolent chronic lymphocytic leukemia: French Cooperative Group on Chronic Lymphocytic Leukemia. N Engl J Med. 1998;338:1506-1514.
44. CLL Trialists' Collaborative Group. Chemotherapeutic options in chronic lymphocytic leukemia: a meta-analysis of the randomized trials. J Natl Cancer Inst. 1999;91:861-868.