EIPL (extensive intraoperative peritoneal lavage) therapy significantly reduces peritoneal recurrence after pancreatectomy in patients with pancreatic cancer

International Journal of Oncology

Volumn 27, Issue 5, 2005, Pages 1321-1328

  Yamamoto, Kenichiro ^a   Shimada, Shinya ^a,b   Hirota, Masahiko ^a   Yagi, Yasushi ^c   Matsuda, Masakazu ^b   Baba, Hideo ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KUMAMOTO CITY HOSPITAL   (Japan)

^c Kumamoto Regional Medical Center   (Japan)

Author keywords

EIPL therapy; Pancreatic cancer; Peritoneal dissemination; Peritoneal free cancer cells; Prognosis; Recurrence; RT PCR

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CYTOKERATIN 20; INTERMEDIATE FILAMENT PROTEIN; KRT20 PROTEIN, HUMAN;

AGED; ARTICLE; CANCER INVASION; CLINICAL TRIAL; FEMALE; HUMAN; INTRAOPERATIVE PERIOD; MALE; METASTASIS; MIDDLE AGED; PANCREAS CARCINOMA; PANCREAS RESECTION; PANCREAS TUMOR; PATHOLOGY; PERITONEUM LAVAGE; PERITONEUM TUMOR; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT OUTCOME; TUMOR RECURRENCE;

AGED; CARCINOEMBRYONIC ANTIGEN; CARCINOMA, PANCREATIC DUCTAL; FEMALE; HUMANS; INTERMEDIATE FILAMENT PROTEINS; INTRAOPERATIVE PERIOD; KERATIN-20; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; PANCREATECTOMY; PANCREATIC NEOPLASMS; PERITONEAL LAVAGE; PERITONEAL NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TREATMENT OUTCOME;

EID: 33644649923     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.27.5.1321     Document Type: Article

References (49)

1. Niederhuber JE, Brennan MF and Menck HR: The National Cancer Data Base report on pancreatic cancer. Cancer 76: 1671-1677,1995.
2. Trede M, Schwall G and Saeger HD: Survival after pancreato-duodenectomy. 118 consecutive resections without an operative mortality. Ann Surg 211: 447-458, 1990.
3. Warshaw AL and Fernandez-del Castillo C: Pancreatic carcinoma. N Engl J Med 326: 455-465,1992.
4. Geer RJ and Brennan MF: Prognostic indicators for survival after resection of pancreatic adenocarcinoma. Am J Surg 165: 68-72,1993.
5. Nitecki SS, Sarr MG, Colby TV and van Heerden JA: Longterm survival after resection for ductal adenocarcinoma of the pancreas. Is it really improving? Ann Surg 221: 59-66, 1995.
6. Li D, Xie K, Wolff R and Abbruzzese JL: Pancreatic cancer. Lancet 363: 1049-1057,2004.
7. Griffin JF, Smalley SR, Jewell W, et al Patterns of failure after curative resection of pancreatic carcinoma. Cancer 66: 56-61, 1990.
8. Del Castillo CF and Warshaw L: Peritoneal metastases in pancreatic carcinoma. Hepatogastroenterology 40: 430-432,1993.
9. Kayahara M, Nagakawa T, Ueno K, Ohta T, Takeda T and Miyazaki I: An evaluation of radical resection for pancreatic cancer based on the mode of recurrence as determined by autopsy and diagnostic imaging. Cancer 72: 2118-2123,1993.
10. Sperti C, Pasquali C, Piccoli A and Pedrazzoli S: Recurrence after resection for ductal adenocarcinoma of the pancreas. World J Surg 21: 195-200,1997.
11. Kremer B, Vogel I, Lüttges J, Klöppel G and Henne-Bruns D: Surgical possibilities for pancreatic cancer: extended resection. Ann Oncol 10 (suppl. 4): 252-256,1999.
12. Klinkenbijl JH, Jeekel J, Sahmoud T, et al Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: phase III trial of the EORTC gastrointestinal tract cancer cooperative group. Ann Surg 230: 776-782,1999.
13. Henne-Bruns D, Vogel I, Lüttges J, Klöppel G and Kremer B: Surgery for ductal adenocarcinoma of the pancreatic head: staging, complications, and survival after regional versus extended lymphadenectomy. World J Surg 24: 595-601, 2000.
14. Wagner M, Redaelli C, Lietz M, Seiler CA, Friess H and Biichler MW: Curative resection is the single most important factor determining outcome in patients with pancreatic adenocarcinoma. Br J Surg 91: 586-594, 2004.
15. Thorban S, Roder JD, Pantel K and Siewert JR: Immunocytochemical detection of isolated epithelial tumor cells in bone marrow of patients with pancreatic carcinoma. Am J Surg 172: 297-298, 1996.
16. Tamagawa E, Ueda M, Takahashi S, et al: Pancreatic lymph nodal and plexus micrometastases detected by enriched polymerase chain reaction and nonradioisotopic single-strand conformation polymorphism analysis: a new predictive factor for recurrent pancreatic carcinoma. Clin Cancer Res 3: 2143-2149, 1997.
17. Demeure MJ, Doffek KM, Komorowski RA, et al: Molecular metastases in stage I pancreatic cancer: improved survival with adjuvant chemoradiation. Surgery 124: 663-669, 1998.
18. Sales JP, Wind P, Douard R, Cugnenc PH and Loric S: Blood dissemination of colonic epithelial cells during no-touch surgery for rectosigmoid cancer. Lancet 354: 392, 1999.
19. Sadahiro S, Suzuki T, Tokunaga N, et al Detection of tumor cells in the portal and peripheral blood of patients with colorectal carcinoma using competitive reverse transcriptase-polymerase chain reaction. Cancer 92: 1251-1258, 2001.
20. Marutsuka T, Shimada S, Shiomori K, et al Mechanisms of peritoneal metastasis after operation for non-serosa-invasive gastric carcinoma: an ultrarapid detection system for intraperitoneal free cancer cells and a prophylactic strategy for peritoneal metastasis. Clin Cancer Res 9: 678-685,2003.
21. Shimada S, Tanaka E, Marutsuka T, et al Extensive intraoperative peritoneal lavage and chemotherapy for gastric cancer patients with peritoneal free cancer cells. Gastric Cancer 5: 168-172,2002.
22. Hirota M, Shimada S, Yamamoto K, et al Pancreatectomy using the no-touch isolation technique followed by extensive intraoperative peritoneal lavage to prevent cancer cell dissemination: a pilot study. JOP 6: 143-151,2005.
23. Sobin L and Wittekind C: UICC (International Union against Cancer) TNM classification of malignant tumours. 6th edition. Wiley-Liss., New York, pp93-96, 2002.
24. Kessler HH, Muhlbauer G, Stelzl E, Daghofer E, Santner BI and Marth E: Fully automated nucleic acid extraction: MagNA Pure LC. Clin Chem 47: 1124-1126,2001.
25. Wittwer CT, Herrmann MG, Moss AA and Rasmussen RP: Continuous fluorescence monitoring of rapid cycle DNA amplification. Biotechniques 22: 130-138,1997.
26. Nieveen van Dijkum EJ, Sturm PD, De Wit LT, Offerhaus J, Obertop H and Gouma DJ: Cytology of peritoneal lavage performed during staging laparoscopy for gastrointestinal malignancies: is it useful? Ann Surg 228: 728-733,1998.
27. Shimada S, Yagi Y, Shiomori K, et al Characterization of early gastric cancer and proposal of the optimal therapeutic strategy. Surgery 129:714-719,2001.
28. Bosch B, Guller U, Schnider A, et al Perioperative detection of disseminated tumour cells is an independent prognostic factor in patients with colorectal cancer. Br J Surg 90: 882-888 2003.
29. Bando E, Yonemura Y, Takeshita Y, et al Intraoperative lavage for cytological examination in 1,297 patients with gastric carcinoma. Am J Surg 178: 256-262,1999.
30. Makary MA, Warshaw AL, Centeno BA, Willet CG, Rattner DW and Fernández-del Castillo C: Implications of peritoneal cytology for pancreatic cancer management. Arch Surg 133: 361-365,1998.
31. Merchant NB, Conlon KC, Saigo P, Dougherty E and Brennan MF: Positive peritoneal cytology predicts unresectability of pancreatic adenocarcinoma. J Am Coll Surg 188: 421-426,1999.
32. Abe S, Yoshimura H, Tabara H, et al Curative resection of gastric cancer: limitation of peritoneal lavage cytology in predicting the outcome. J Surg Oncol 59: 226-229,1995.
33. Yamamoto N, Kato Y, Yanagisawa A, Ohta H, Takahashi T and Kitagawa T: Predictive value of genetic diagnosis for cancer micrometastasis: histologic and experimental appraisal. Cancer 80:1393-1398,1997.
34. Neumaier M, Gerhard M and Wagener C: Diagnosis of micrometastases by the amplification of tissue-specific genes. Gene 159:43-47,1995.
35. Okada Y, Fujiwara Y, Yamamoto H, et al Genetic detection of lymph node micrometastases in patients with gastric carcinoma by multiple-marker reverse transcriptase-polymerase chain reaction assay. Cancer 92: 2056-2064, 2001.
36. Hampton R, Walker M, Marshall J and Juhl H: Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells. Oncogene 21: 7817-7823, 2002.
37. Ho SB, Hyslop A, Albrecht R, et al Quantification of colorectal cancer micrometastases in lymph nodes by nested and realtime reverse transcriptase-PCR analysis for carcinoembryonic antigen. Clin Cancer Res 10: 5777-5784, 2004.
38. Ko Y, Klinz M, Totzke G, Gouni-Berthold I, Sachinidis A and Vetter H: Limitations of the reverse transcription-polymerase chain reaction method for the detection of carcinoembryonic antigen-positive tumor cells in peripheral blood. Clin Cancer Res 4: 2141-2146,1998.
39. Yoshizawa K, Nagai H, Kurihara K, Sata N, Kawai T and Saito K: Long-term survival after surgical resection for pancreatic cancer. Hepatogastroenterology 48: 1153-1156, 2001.
40. Yachida S, Fukushima N, Sakamoto M, Matsuno Y, Kosuge T and Hirohashi S: Implications of peritoneal washing cytology in patients with potentially resectable pancreatic cancer. Br J Surg 89:573-578,2002.
41. Ishikawa O, Wada H, Ohigashi H, et al. Postoperative cytology for drained fluid from the pancreatic bed after 'curative' resection of pancreatic cancers: does it predict both the patient's prognosis and the site of cancer recurrence? Ann Surg 238: 103-110, 2003.
42. Vogel I, Rrüger U, Marxsen J, et al Disseminated tumor cells in pancreatic cancer patients detected by immunocytology: a new prognostic factor. Clin Cancer Res 5: 593-599,1999.
43. Nomoto S, Nakao A, Kasai Y, et al. Peritoneal washing cytology combined with immunocytochemical staining and detecting mutant K-ras in pancreatic cancer: comparison of the sensitivity and availability of various methods. Pancreas 14: 126-132, 1997.
44. Leach SD, Rose JA, Lowy AM, et al. Significance of peritoneal cytology in patients with potentially resectable adenocarcinoma of the pancreatic head. Surgery 118: 472-478,1995.
45. Nakatsuka A, Yamaguchi K, Shimizu S, et al. Positive washing cytology in patients with pancreatic cancer indicates a contraindication of pancreatectomy. Int J Surg Investig 1: 311-317, 1999.
46. Kurizaki T, Egami H, Hirota M, et al: Characterization of cancer cell dissociation factor in a highly invasive pancreatic cancer cell line. Cancer 75: 1554-1561,1995.
47. Shimada S, Yamaguchi K, Takahashi M and Ogawa M: Pancreatic elastase IEA and its variants are expressed in pancreatic carcinoma cells. Int J Mol Med 10: 599-603, 2002.
48. Hirota M, Egami H, Corra S, et at Production of scatter factorlike activity by a nitrosamine-induced pancreatic cancer cell line. Carcinogenesis 14: 259-264, 1993.
49. Iitsuka Y, Kaneshima S, Tanida O, Takeuchi T and Koga S: Intraperitoneal free cancer cells and their viability in gastric cancer. Cancer 44: 1476-1480,1979.