The tuberous sclerosis genes, TSC1 and TSC2, trigger different gene expression responses

International Journal of Oncology

Volumn 27, Issue 5, 2005, Pages 1411-1424

  Rosner, Margit ^a   Freilinger, Angelika ^a   Lubec, Gert ^b   Hengstschläger, Markus ^a  

^a UNIV KLIN FÜR FRAUENHEILKUNDE   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Hamartin; Microarray; TSC1; TSC2; Tuberin; Tuberous sclerosis

Indexed keywords

TUBERIN; TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; DNA MICROARRAY; DOWN REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HELA CELL; HUMAN; PHYSIOLOGY; UPREGULATION;

DOWN-REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 33644646779     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.27.5.1411     Document Type: Article

References (32)

1. Gomez MR, Sampson JR and Whittemore VH: Tuberous Sclerosis Complex. 3rd edition. Oxford University Press, New York, NY, 1999.
2. Osborn JP, Fryer A and Webb D: Epidemiology of tuberous sclerosis. Ann NY Acad Sci 615: 125-127,1991.
3. Young J and Povey S: The genetic basis of tuberous sclerosis. Mol Med Today 4: 313-319,1998.
4. Cheadle JP, Reeve MP, Sampson JR and Kwiatkowski DJ: Molecular genetic advances in tuberous sclerosis. Hum Genet 107:97-114,2000.
5. The European Chromosome 16 Tuberous Sclerosis Consortium: Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell 75: 1305-1315,1993.
6. The TSC1 Consortium: Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science 277: 805-808, 1997.
7. Jones AC, Daniells CE, Snell RG, Tachataki M, Idziaszczyk SA, Krawczak M, Sampson JR and Cheadle JP: Molecular genetic and phenotypic analysis reveals differences between TSC1 and TSC2 associated familial and sporadic tuberous sclerosis. Hum Mol Genet 6: 2155-2161,1997.
8. De Vries PJ and Bolton PF: Genotype-phenotype correlations in tuberous sclerosis. J Med Genet 37: E3, 2000.
9. Dabora SL, Jozwiak S, Franz DN, Roberts PS, Nieto A, Chung J, Choy YS, Reeve MP, Thiele E, Egelhoff JC, Kasprzyk-Obara J, Domanska-Pakiela D and Kwiatkowski DJ: Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs. Am J Hum Genet 8:68, 2000.
10. Van Slegtenhorst M, Nellist M, Nagelkerken B, Cheadle J, Snell R, van den Ouweland A, Reuser A, Sampson J, Halley D and van der Sluijs P: Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products. Hum Mol Genet 7: 1053-1057, 1998.
11. Plank TL, Yeung RS and Henske EP: Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localised to cytoplasmic vesicles. Cancer Res 58: 4766-4770,1998.
12. Nellist M, van Slegtenhorst MA, Goedbloed M, van den Ouweland AMW, Halley DJ and van der Sluijs P: Characterization of the cytosolic tuberin-hamartin complex: tuberin is a cytosolic chaperone for hamartin. J Biol Chem 275: 35647-35652,1999.
13. Miloloza A, Rosner M, Nellist M, Halley D, Bernaschek G and Hengstschläger M: The TSC1 gene product, hamartin, negatively regulates cell proliferation. Hum Mol Genet 9: 1721-1727,2000.
14. Rosner M, Fredinger A and Hengstschläger M: Proteins interacting with the tuberous sclerosis gene products. Amino Acids 27: 119-128,2004.
15. Soucek T, Pusch O, Wienecke R, De Clue JE and Hengstschläger M: Role of the tuberous sclerosis gene-2 product in cell cycle control. J Biol Chem 272: 29301-29308, 1997.
16. Soucek T, Yeung RS and Hengstschläger M: Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2. Proc Natl Acad Sci USA 95' 15653-15658, 1998.
17. Rosner M and Hengstschläger M: Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2. J Biol Chem 279: 48707-48715, 2004.
18. Li Y, Corradetti MN, Inoki K and Guan KL: TSC2: filling the GAP in the mTOR signalling pathway. Trends Biochem Sci 29: 32-38,2003.
19. Pan D, Dong J, Zhang Y and Gao X: Tuberous sclerosis complex: from Drosophila to human disease. Trends Cell Biol 14: 78-85 2004.
20. Tsuchiya H, Orimoto K, Kobayashi T and Hino O: Presence of potent transcriptional activation domains in the predisposing tuberous sclerosis (Tsc2) gene product of the Eker rat model. Cancer Res 56: 429-433,1996.
21. Henry KW, Yuan X, Koszewski NJ, Onda DJ, Kwiatkowski DJ and Noonan DJ: Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members. J Biol Chem 273: 20535-20539,1998.
22. Lou D, Griffith N and Noonan DJ: The tuberous sclerosis 2 gene product can localize to nuclei in a phosphorylation-dependent manner. Mol Cell Biol Res Commun 4: 374-380, 2001.
23. Rosner M, Hofer K, Kubista M and Hengstschläger M: Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38. Oncogene 22: 4786-4798, 2003.
24. Schiene-Fischer C and Yu C: Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases. FEBS Lett 495: 1-6,2001.
25. Sen B, Wolf DC and Hester SD: The transcriptional profile of the kidney in TSC2 heterozygous mutant Long Evans (Eker) rats compared to wild-type. Mutat Res 549: 213-224, 2004.
26. Fukuda T, Kobayashi T, Momose S, Yasui H and Hino O: Distribution of Tscl protein detected by immunohistochemistry in various normal rat tissues and the renal carcinomas of Eker rat: detection of limited colocalization with Tscl and Tsc2 gene products in vivo. Lab Invest 80: 1347-1359,2000.
27. Gutmann DH, Zhang Y, Hasbani MJ, Goldberg MP, Plank TL and Henske EP: Expression of the tuberous sclerosis complex gene products, hamartin and tuberin, in central nervous system tissues. Acta Neuropathol 99: 223-230,2000.
28. Murthy V, Haddad LA, Smith N, Pinney D, Tyskowski R, Brown D and Ramesh V: Similarities and differences in the subcellular localization of hamartin and tuberin in the kidney. Am J Physiol Renal Physiol 278: F737-F746, 2000.
29. Onda A, Lueck A, Marks PW, Warren HB and Kwiatkowski DJ: TSC2+/- mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. J Cin Invest 104: 687-695,1999.
30. Kobayashi T, Minowa O, Kuno J, Mitani H, Hino O and Noda T: Renal carcinogenesis, hepatic hemangiomatosis and embryonic lethality caused by a germ-line TSC2 mutation in mice. Cancer Res 59: 1206-1211,1999.
31. Kobayashi T, Minowa O, Sugitani Y, Takai S, Mitani H, Kobayashi E, Noda T and Hino O: A germ-line Tscl mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice. Proc Natl Acad Sci USA 98: 8762-8767,2001.
32. Miloloza A, Kubista M, Rosner M and Hengstschläger M: Evidence for separable functions of tuberous sclerosis gene products in mammalian cell cycle regulation. J Neuropath Exp Neurol 61: 154-163,2002.