N-Acetyl-seryl-aspartyl-lysyl-proline inhibits DNA synthesis in human mesangial cells via up-regulation of cell cycle modulators

Biochemical and Biophysical Research Communications

Volumn 342, Issue 3, 2006, Pages 758-765

  Kanasaki, Keizo ^a   Haneda, Masakazu ^b   Sugimoto, Toshiro ^a   Shibuya, Kazuyuki ^a   Isono, Motohide ^a   Isshiki, Keiji ^a   Araki, Shin Ichi ^a   Uzu, Takashi ^a   Kashiwagi, Atsunori ^a   Koya, Daisuke ^c  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b ASAHIKAWA MEDICAL COLLEGE   (Japan)

^c KANAZAWA MEDICAL UNIVERSITY   (Japan)

Author keywords

Ac SDKP; ACE inhibitor; CDK inhibitors; p53; PDGF BB; Protein stability

Indexed keywords

AUTACOID; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; DNA; PLATELET DERIVED GROWTH FACTOR BB; PROTEIN P53; SERASPENIDE; SMALL INTERFERING RNA;

ARTICLE; CELL CYCLE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; CYTOTOXICITY; DISEASE COURSE; DNA SYNTHESIS INHIBITION; DRUG EFFECT; EXAMINATION; FETAL CALF SERUM; HUMAN; HUMAN CELL; KIDNEY DISEASE; KNOCKOUT GENE; MESANGIUM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; UPREGULATION;

CELL CYCLE; CELLS, CULTURED; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DNA REPLICATION; GLOMERULAR MESANGIUM; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; NUCLEIC ACID SYNTHESIS INHIBITORS; OLIGOPEPTIDES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 33644614035     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.02.019     Document Type: Article

References (30)

1. C. Grillon, K. Rieger, J. Bakala, D. Schott, J.L. Morgat, E. Hannappel, W. Voelter, and M. Lenfant Involvement of thymosin beta 4 and endoproteinase Asp-N in the biosynthesis of the tetrapeptide AcSerAspLysPro a regulator of the hematopoietic system FEBS Lett. 274 1990 30 34
2. J. Wdzieczak-Bakala, M.P. Fache, M. Lenfant, E. Frindel, and F. Sainteny AcSDKP, an inhibitor of CFU-S proliferation, is synthesized in mice under steady-state conditions and secreted by bone marrow in long-term culture Leukemia 1990 235 237
3. M. Azizi, A. Rousseau, E. Ezan, T.T. Guyene, S. Michelet, J.M. Grognet, M. Lenfant, P. Corvol, and J. Menard Acute angiotensin-converting enzyme inhibition increases the plasma level of the natural stem cell regulator N-acetyl-seryl-aspartyl-lysyl-proline J. Clin. Invest. 97 1996 839 844
4. M. Lombard, D. Sotty, J. Wdzieczak-Bakala, and M. Lenfant In vivo effect of the tetrapeptide, N-acetyl-Ser-Asp-Lys-Pro, on the G1-S transition of rat hepatocytes Cell Tissue Kinet. 23 1990 99 101
5. N. Iwamoto, H.J. Xano, T. Yoshioka, H. Shiraga, K. Nitta, T. Muraki, and K. Ito Acetyl-seryl-aspartyl-lysyl-proline is a novel natural cell cycle regulator of renal cells Life Sci. 66 2000 PL221 PL226
6. N.E Rhaleb, H. Peng, P. Harding, M. Tayeh, M.C. LaPointe, and O.A. Carretero Effect of N-acetyl-seryl-aspartyl-lysyl-proline on DNA and collagen synthesis in rat cardiac fibroblasts Hypertension 37 2001 827 832
7. K. Kanasaki, D. Koya, T. Sugimoto, M. Isono, A. Kashiwagi, and M. Haneda N-Acetyl-seryl-aspartyl-lysyl-proline inhibits TGF-beta-mediated plasminogen activator inhibitor-1 expression via inhibition of Smad pathway in human mesangial cells J. Am. Soc. Nephrol. 14 2003 863 872
8. K. Shibuya, K. Kanasaki, M. Isono, H. Sato, M. Omata, T. Sugimoto, S. Araki, K. Isshiki, A. Kashiwagi, M. Haneda, and D. Koya N-Acetyl-seryl-aspartyl- lysyl-proline prevents renal insufficiency and mesangial matrix expansion in diabetic db/db mice Diabetes 54 2005 838 845
9. G. Choudhury Akt serine threonine kinase regulates platelet-derived growth factor-induced DNA synthesis in glomerular mesangial cells: regulation of c-fos AND p27(kip1) gene expression J. Biol. Chem. 21 2001 35636 35643
10. G. Choudhury, C. Karamitsos, J. Hernandez, A. Gentilini, J. Bardgette, and H. Abboud PI-3-kinase and MAPK regulate mesangial cell proliferation and migration in response to PDGF Am. J. Physiol. 273 1997 F931 F938
11. M. Perry, and A. Levine Tumor-suppressor p53 and the cell cycle Curr. Opin. Genet. Dev. 3 1993 50 54
12. P. Andreassen, O. Lohez, F. Lacroix, and R. Margolis Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1 Mol. Biol. Cell 12 2001 1315 1328
13. P. Stukenberg Triggering p53 after cytokinesis failure J. Cell Biol. 7 2004 607 608
14. S. Fuchs, V. Adler, T. Buschmann, X. Wu, and Z. Ronai Mdm2 association with p53 targets its ubiquitination Oncogene 12 1998 2543 2547
15. J. Momand, G. Zambetti, D. Olson, D. George, and A. Levine The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation Cell 26 1992 1237 1245
16. C. Maki, J. Huibregtse, and P. Howley In vivo ubiquitination and proteasome-mediated degradation of p53 Cancer Res. 1 1996 2649 2654
17. G. Zahner, G. Wolf, M. Ayoub, R. Reinking, U. Panzer, S.R. Shankland, and R. Stahl Cyclooxygenase-2 overexpression inhibits platelet-derived growth factor-induced mesangial cell proliferation through induction of the tumor suppressor gene p53 and the cyclin-dependent kinase inhibitors p21waf-1/cip-1 and p27kip-1 J. Biol. Chem. 22 2002 9763 9771
18. W. el-Deiry, T. Tokino, V. Velculescu, D. Levy, R. Parsons, J. Trent, D. Lin, W. Mercer, K. Kinzler, and B. Vogelstein WAF1, a potential mediator of p53 tumor suppression Cell 19 1993 817 825
19. J. Harper, G. Adami, N. Wei, K. Keyomarsi, and S. Elledge The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases Cell 19 1993 805 816
20. C. Dietrich, T. Bartsch, F. Schanz, F. Oesch, and R. Wieser p53-dependent cell cycle arrest induced by N-acetyl-l-leucinyl-l-leucinyl-l-norleucinal in platelet-derived growth factor-stimulated human fibroblasts Proc. Natl. Acad. Sci. USA 1 1996 10815 10819
21. S. Hayashi, R. Morishita, H. Matsushita, H. Nakagami, Y. Taniyama, T. Nakamura, M. Aoki, K. Yamamoto, J. Higaki, and T. Ogihara Cyclic AMP inhibited proliferation of human aortic vascular smooth muscle cells, accompanied by induction of p53 and p21 Hypertension 35 2000 237 243
22. A. Takahashi, T. Taniguchi, Y. Ishikawa, and M. Yokoyama Tranilast inhibits vascular smooth muscle cell growth and intimal hyperplasia by induction of p21(waf1/cip1/sdi1) and p53 Circ. Res. 19 1999 543 550
23. J. Philipp-Staheli, K. Kim, D. Liggitt, K. Gurley, G. Longton, and C. Kemp Distinct roles for p53, p27Kip1, and p21Cip1 during tumor development Oncogene 29 2004 905 913
24. M. Kemp, B. Jeffy, and D. Romagnolo Conjugated linoleic acid inhibits cell proliferation through a p53-dependent mechanism: effects on the expression of G1-restriction points in breast and colon cancer cells J. Nutr. 133 2003 3670 3677
25. J. Cashman, A. Eaves, and C. Eaves The tetrapeptide AcSDKP specifically blocks the cycling of primitive normal but not leukemic progenitors in long-term culture: evidence for an indirect mechanism Blood 1 1994 1534 1542
26. P. Chen, Y. Chen, R. Bookstein, and W. Lee Genetic mechanisms of tumor suppression by the human p53 gene Science 250 1990 1576 1580
27. E. Feinstein, G. Cimino, R. Gale, G. Alimena, R. Berthier, K. Kishi, J. Goldman, A. Zaccaria, A. Berrebi, and E. Canaani p53 in chronic myelogenous leukemia in acute phase Proc. Natl. Acad. Sci. USA 88 1991 6293 6297
28. S. Bi, T. Hughes, J. Bungey, A. Chase, P. de Fabritiis, and J. Goldman p53 in chronic myeloid leukemia cell lines Leukemia 6 1992 839 842
29. S. Klahr, G. Schreiner, and I. Ichikawa The progression of renal disease N. Engl. J. Med. 318 1998 1657 1666
30. J. Floege, E. Eng, B. Young, and R. Johnson Factors involved in the regulation of mesangial cell proliferation in vitro and in vivo Kidney Int. Suppl. 39 1993 S47 S54