Decreased soluble leptin receptor levels in women with polycystic ovary syndrome

European Journal of Endocrinology

Volumn 154, Issue 2, 2006, Pages 287-294

  Hahn, Susanne ^a   Haselhorst, Uwe ^b   Quadbeck, Beata ^a   Tan, Susanne ^a   Kimmig, Rainer ^a   Mann, Klaus ^a   Janssen, Onno E ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b Biofocus GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; LEPTIN RECEPTOR;

ADULT; ANTHROPOMETRY; ARTICLE; BODY FAT; BODY FAT DISTRIBUTION; BODY MASS; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE TEST; HUMAN; HYPERANDROGENISM; INSULIN RESISTANCE; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; OBESITY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK FACTOR; STATISTICAL SIGNIFICANCE; WAIST CIRCUMFERENCE;

ADULT; ANDROSTENEDIONE; BLOOD GLUCOSE; BODY COMPOSITION; BODY MASS INDEX; CHOLESTEROL; ESTRADIOL; FEMALE; HUMANS; HYDROCORTISONE; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR I; LEPTIN; OBESITY; POLYCYSTIC OVARY SYNDROME; RECEPTORS, CELL SURFACE; SEX HORMONE-BINDING GLOBULIN; STATISTICS, NONPARAMETRIC; TESTOSTERONE; THYROTROPIN;

EID: 33644583292     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.1.02078     Document Type: Article

References (50)

1. Asuncion M, Calvo RM, San Millan JL, Sancho J, Avila S & Escobar-Morreale HF. A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain. Journal of Clinical Endocrinology and Metabolism 2000 85 2434-2438.
2. Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES & Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. Journal of Clinical Endocrinology and Metabolism 2004 89 2745-2749.
3. Dunaif A, Segal KR, Futterweit W & Dobrjansky A. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 1989 38 1165-1174.
4. Loverro G, Lorusso F, Mei L, Depalo R, Cormio G & Selvaggi L. The plasma homocysteine levels are increased in polycystic ovary syndrome. Gynecologic and Obstetric Investigation 2002 53 157-162.
5. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L & Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994 372 425-432.
6. Janeckova R. The role of leptin in human physiology and pathophysiology. Physiological Research 2001 50 443-459.
7. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL et al. Serum immunoreactive leptin concentrations in normal-weight and obese humans. New England Journal of Medicine 1996 334 292-295.
8. Gennarelli G, Holte J, Wide L, Berne C & Lithell H. Is there a role for leptin in the endocrine and metabolic aberrations of polycystic ovary syndrome? Human Reproduction 1998 13 535-541.
9. Maliqueo M, Perez-Bravo F, Calvillan M, Piwonka V, Castillo T & Sir-Petermann T. Relationship between leptin and insulin sensitivity in patients with polycystic ovary syndrome (In Spanish). Medicina Clinica 1999 113 526-530.
10. Pirwany IR, Fleming R, Sattar N, Greer IA & Wallace AM. Circulating leptin concentrations and ovarian function in polycystic ovary syndrome. European Journal of Endocrinology 2001 145 289-294.
11. Telli MH, Yildirim M & Noyan V. Serum leptin levels in patients with polycystic ovary syndrome. Fertility and Sterility 2002 77 932-935.
12. Ahima RS, Dushay J, Flier SN, Prabakaran D & Flier JS. Leptin accelerates the onset of puberty in normal female mice. Journal of Clinical Investigation 1997 99 391-395.
13. Agarwal SK, Vogel K, Weitsman SR & Magoffin DA. Leptin antagonizes the insulin-like growth factor-I augmentation of steroidogenesis in granulosa and theca cells of the human ovary. Journal of Clinical Endocrinology and Metabolism 1999 84 1072-1076.
14. Biason-Lauber A, Zachmann M & Schoenle EJ. Effect of leptin on CYP17 enzymatic activities in human adrenal cells: new insight in the onset of adrenarche. Endocrinology 2000 141 1446-1454.
15. Carmina E, Ferin M, Gonzalez F & Lobo RA. Evidence that insulin and androgens may participate in the regulation of serum leptin levels in women. Fertility and Sterility 1999 72 926-931.
16. Spritzer PM, Poy M, Wiltgen D, Mylius LS & Capp E. Leptin concentrations in hirsute women with polycystic ovary syndrome or idiopathic hirsutism: influence on LH and relationship with hormonal, metabolic, and anthropometric measurements. Human Reproduction 2001 16 1340-1346.
17. Laughlin GA, Morales AJ & Yen SS. Serum leptin levels in women with polycystic ovary syndrome: the role of insulin resistance/hyperinsulinemia. Journal of Clinical Endocrinology and Metabolism 1997 82 1692-1696.
18. Sir-Petermann T, Recabarren SE, Lobos A, Maliqueo M & Wildt L. Secretory pattern of leptin and LH during lactational amenorrhoea in breastfeeding normal and polycystic ovarian syndrome women. Human Reproduction 2001 16 244-249.
19. Lammert A, Kiess W, Bottner A, Glasow A & Kratzsch J. Soluble leptin receptor represents the main leptin binding activity in human blood. Biochemical and Biophysical Research Communications 2001 283 982-988.
20. Kado N, Kitawaki J, Koshiba H, Ishihara H, Kitanka Y, Teramoto M & Honjo H. Relationships between the serum levels of soluble leptin receptor and free and bound leptin in non-pregnant women of reproductive age and women undergoing controlled ovarian hyperstimulation. Human Reproduction 2003 18 715-720.
21. Sinha MK, Opentanova I, Ohannesian JP, Kolaczynski JW, Heiman ML, Hale J, Becker GW, Bowsher RR, Stephens TW & Caro JF. Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting. Journal of Clinical Investigation 1996 98 1277-1282.
22. Ogawa T, Hirose H, Yamamoto Y, Nishikai K, Miyashita K, Nakamura H, Saito I & Saruta T. Relationships between serum soluble leptin receptor level and serum leptin and adiponectin levels, insulin resistance index, lipid profile, and leptin receptor gene polymorphisms in the Japanese population. Metabolism 2004 53 879-885.
23. van Dielen FM, van't Veer C, Buurman WA & Greve JW. Leptin and soluble leptin receptor levels in obese and weight-losing individuals. Journal of Clinical Endocrinology and Metabolism 2002 87 1708-1716.
24. Yannakoulia M, Yiannakouris N, Bluher S, Matalas AL, Klimis-Zacas D & Mantzoros CS. Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans. Journal of Clinical Endocrinology and Metabolism 2003 88 1730-1736.
25. Misra M, Miller KK, Almazan C, Ramaswamy K, Aggarwal A, Herzog DB, Neubauer G, Breu J & Klibanski A. Hormonal and body composition predictors of soluble leptin receptor, leptin, and free leptin index in adolescent girls with anorexia nervosa and controls and relation to insulin sensitivity. Journal of Clinical Endocrinology and Metabolism 2004 89 3486-3495.
26. Li HJ, Ji CY, Wang W & Hu YH. A twin study for serum leptin, soluble leptin receptor and free insulin-like growth factor-1 in pubertal females. Journal of Clinical Endocrinology and Metabolism 2005 90 3659-3664.
27. Matthews D, Hosker J, Rudenski A, Naylor B, Treacher D & Turner R. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985 28 412-419.
28. Matsuda M & DeFronzo R. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999 22 1462-1470.
29. Chapman IM, Wittert GA & Norman RJ. Circulating leptin concentrations in polycystic ovary syndrome: relation to anthropometric and metabolic parameters. Clinical Endocrinology 1997 46 175-181.
30. Rouru J, Anttila L, Koskinen P, Penttila TA, Irjala K, Huupponen R & Koulu M. Serum leptin concentrations in women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 1997 82 1697-1700.
31. Mantzoros CS, Dunaif A & Flier JS. Leptin concentrations in the polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 1997 82 1687-1691.
32. De Vos P, Saladin R, Auwerx J & Staels B. Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. Journal of Biological Chemistry 1995 270 15958-15961.
33. Koistinen H. Serum leptin concentration is normal in Cushing syndrome and in acromegaly. Diabetologia 1996 39 A59.
34. Bornstein SR, Uhlmann K, Haidan A, Ehrhart-Bornstein M & Scherbaum WA. Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: leptin inhibits cortisol release directly. Diabetes 1997 46 1235-1238.
35. Gomez JM, Maravall FJ, Gomez N, Navarro MA, Casamitjana R & Soler J. Interactions between serum leptin, the insulin-like growth factor-I system, and sex, age, anthropometric and body composition variables in a healthy population randomly selected. Clinical Endocrinology 2003 58 213-219.
36. Kowalska I, Kinalski M, Straczkowski M, Wolczyski S & Kinalska I. Insulin, leptin, IGF-I and insulin-dependent protein concentrations after insulin-sensitizing therapy in obese women with polycystic ovary syndrome. European Journal of Endocrinology 2001 144 509-515.
37. Mendonca HC, Montenegro RM Jr, Foss MC, Silva de Sa MF & Ferriani RA. Positive correlation of serum leptin with estradiol levels in patients with polycystic ovary syndrome. Brazilian Journal of Medical and Biological Research 2004 37 729-736.
38. Yoshida T, Monkawa T, Hayashi M & Saruta T. Regulation of expression of leptin mRNA and secretion of leptin by thyroid hormone in 3T3-L1 adipocytes. Biochemical and Biophysical Research Communications 1997 232 822-826.
39. Erel CT, Senturk LM, Kaleli S, Gezer A, Baysal B & Tasan E. Is serum leptin level regulated by thyroid functions, lipid metabolism and insulin resistance in polycystic ovary syndrome? Gynecological Endocrinology 2003 17 223-229.
40. Janssen OE, Mehlmauer N, Hahn S, Offner AH & Gartner R. High prevalence of autoimmune thyroiditis in patients with polycystic ovary syndrome. European Journal of Endocrinology 2004 150 363-369.
41. Pinkney JH, Goodrick SJ, Katz J, Johnson AB, Lightman SL, Coppack SW & Mohamed-Ali V. Leptin and the pituitary-thyroid axis: a comparative study in lean, obese, hypothyroid and hyperthyroid subjects. Clinical Endocrinology 1998 49 583-588.
42. Tagliaferri M, Berselli ME, Calo G, Minocci A, Savia G, Petroni ML, Viberti GC & Liuzzi A. Subclinical hypothyroidism in obese patients: relation to resting energy expenditure, serum leptin, body composition, and lipid profile. Obesity Research 2001 9 196-201.
43. Houseknecht KL, Baile CA, Matteri RL & Spurlock ME. The biology of leptin: a review. Journal of Animal Science 1998 76 1405-1420.
44. Landt M, Parvin CA & Wong M. Leptin in cerebrospinal fluid from children: correlation with plasma leptin, sexual dimorphism, and lack of protein binding. Clinical Chemistry 2000 46 854-858.
45. Shimizu H, Shimomura K, Negishi M, Masunaga M, Uehara Y, Sato N, Shimomura Y, Kasai K & Mori M. Circulating concentrations of soluble leptin receptor: influence of menstrual cycle and diet therapy. Nutrition 2002 18 309-312.
46. Chan JL, Bluher S, Yiannakouris N, Suchard MA, Kratzsch J & Mantzoros CS. Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans. Diabetes 2002 51 2105-2112.
47. Kratzsch J, Lammert A, Bottner A, Seidel B, Mueller G, Thiery J, Hebebrand J & Kiess W. Circulating soluble leptin receptor and free leptin index during childhood, puberty, and adolescence. Journal of Clinical Endocrinology and Metabolism 2002 87 4587-4594.
48. Magni P, Liuzzi A, Ruscica M, Dozio E, Ferrario S, Bussi I, Minocci A, Castagna A, Motta M & Savia G. Free and bound plasma leptin in normal weight and obese men and women: relationship with body composition, resting energy expenditure, insulin-sensitivity, lipid profile and macronutrient preference. Clinical Endocrinology 2005 62 189-196.
49. Caro JF, Sinha MK, Kolaczynski JW, Zhang PL & Considine RV. Leptin: the tale of an obesity gene. Diabetes 1996 45 1455-1462.
50. Misra M, Soyka LA, Miller KK, Grinspoon S, Levitsky LL & Klibanski A. Regional body composition in adolescents with anorexia nervosa and changes with weight recovery. American Journal of Clinical Nutrition 2003 77 1361-1367.