Role of CGRP and GABA in the hypotensive effect of intrathecally administered anandamide to anesthetized rats

European Journal of Pharmacology

Volumn 532, Issue 1-2, 2006, Pages 88-98

  Del Carmen García, María ^b   Adler Graschinsky, Edda ^a   Maris Celuch, Stella ^a  

^a Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

aminobutyric acid; Anandamide; Blood pressure; Calcitonin gene related peptide; Nitric oxide; Spinal cord

Indexed keywords

2 HYDROXYSACLOFEN; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; ANANDAMIDE; BACLOFEN; BICUCULLINE; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; CALCITONIN GENE RELATED PEPTIDE[8-37]; MUSCIMOL; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; URETHAN;

4 AMINOBUTYRIC ACID RELEASE; ANESTHESIA; ANIMAL EXPERIMENT; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; GABAERGIC SYSTEM; HOMEOSTASIS; HYPOTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SPINAL CORD; STATISTICAL SIGNIFICANCE;

ANIMALS; ANTIHYPERTENSIVE AGENTS; ARACHIDONIC ACIDS; BACLOFEN; BICUCULLINE; BLOOD PRESSURE; CALCITONIN GENE-RELATED PEPTIDE; CALCIUM CHANNEL BLOCKERS; CAPSAICIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCANNABINOIDS; ENZYME INHIBITORS; GABA AGONISTS; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; INJECTIONS, INTRAVENOUS; INJECTIONS, SPINAL; MALE; MORPHOLINES; NAPHTHALENES; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PEPTIDE FRAGMENTS; POLYUNSATURATED ALKAMIDES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; TIME FACTORS;

EID: 33644559036     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.12.074     Document Type: Article

References (48)

1. J. Ahluwalia, L. Urban, S. Bevan, and I. Nagy Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro Eur. J. Neurosci. 17 2003 2611 2618
2. S.B. Backman, and J.L. Henry Effects of GABA and glycine on sympathetic preganglionic neurons in the upper thoracic intermediolateral nucleus of the cat Brain Res. 277 1983 365 369
3. T.V. Bilfinger, M. Salzet, C. Fimiani, D.G. Deutsch, G. Tramu, and G.B. Stefano Pharmacological evidence for anandamide amidase in human cardiac and vascular tissues Int. J. Cardiol. 64 Suppl. 1 1998 S15 S22
4. 1 receptors decrease contractile performance in human atrial muscle J. Cardiovasc. Pharmacol. 41 2003 657 664
5. D. Bredt, and S.H. Snyder Isolation of nitric oxide synthase, a calmodulin-requiring enzyme Proc. Natl. Acad. Sci. U. S. A. 87 1990 682 685
6. B receptor component in the spinal action of substance P (SP) on arterial blood pressure in the awake rat Br. J. Pharmacol. 136 2002 1169 1177
7. S.A. Deuchars, K.M. Spyer, and M.P. Gilbey Stimulation within the rostral ventrolateral medulla can evoke monosynaptic GABAergic IPSPs in sympathetic preganglionic neurons in vitro J. Neurophysiol. 77 1997 229 235
8. D.G. Deutsch, M.S. Goligorsky, P.G. Schmid, R.J. Krebsbach, H.H.O. Schmid, S.K. Das, S.K. Dey, G. Arreaza, C. Thorup, G. Stefano, and L.C. Moore Production and physiological actions of anandamide in the vasculature of the rat kidney J. Clin. Invest. 100 1997 1538 1546
9. B. Dib Intrathecal chronic catheterization in rat Pharmacol. Biochem. Behav. 20 1984 45 48
10. J.P. Fluckiger, M. Sonnay, N. Boillat, and J. Atkinson Attenuation of the baroceptor reflex by general anesthetic agents in the normotensive rat Eur. J. Pharmacol. 109 1985 105 109
11. E. Friedman, S. Gershon, B. Hine, and M. Torrelio Cardiovascular effects of delta9-tetrahydrocannabinol in conscious and anaesthetized dogs Br. J. Pharmacol. 59 1977 561 563
12. W.R. Ford, S.A. Honan, R. White, and C.R. Hiley Evidence of a novel site mediating anandamide-induced negative inotropic and coronary vasodilator responses in rat isolated hearts Br. J. Pharmacol. 135 2002 1191 1198
13. 1 spinal receptors in urethane-anesthetized rats Naunyn-Schmiedeberg's Arch. Pharmacol. 368 2003 270 276
14. M.C. García, S.M. Celuch, and E. Adler-Graschinsky Possible participation of spinal nitric oxide in the control of the blood pressure in anesthetized rats Brain Res. 764 1997 67 74
15. M.C. García, S.M. Celuch, and E. Adler-Graschinsky Involvement of GABA and glutamate receptors in the blood pressure responses to intrathecally injected sodium nitroprusside in anesthetized rats Eur. J. Pharmacol. 349 1998 245 252
16. M.C. García, M.A. Enero, and S.M. Celuch Hypotensive and hypertensive effects of catecholamines intrathecally injected in anesthetized rats J. Auton. Nerv. Syst. 59 1996 17 26
17. S.J. Gibson, J.M. Polak, J.M. Bloom, I.M. Sabate, P.M. Mulderry, M.A. Ghatei, G.P. McGregor, J.F.B. Morrison, J.S. Kelly, R.M. Evans, and M.G. Rosenfeld Calcitonin gene-related peptide-immunoreactivity in the spinal cord of man and eight other species J. Neurosci. 4 1984 3101 3111
18. E.S. Hayes, and S.M. Carlton Primary afferent interactions: analysis of calcitonin gene-related peptide-immunoreactive terminals in contact with unlabeled and GABA-immunoreactive profiles in the monkey dorsal horn Neuroscience 47 1992 873 896
19. Y. Hirooka, T. Kishi, K. Sakai, H. Shimokawa, and A. Takeshita Effect of overproduction of nitric oxide in the brain stem on the cardiovascular response in conscious rats J. Cardiovasc. Pharmacol. 41 Suppl 1 2003 S119 S126
20. A. Hiura, F. Nasu, and H. Ishizuka Relationship of substance P- and CGRP-immunoreactive central endings of the primary afferent neurons to GABAergic interneurons in the guinea pig substancia gelatinosa Okajimas Folia Anat. Jpn. 74 1998 231 235
21. Y. Hong, and J.L. Henry Spinal mediation of the increases in arterial pressure and heart rate in response to intrathecal administration of bicuculline Brain Res. 513 1990 86 93
22. C. Iadecola, X. Xu, F. Zhang, J. Hu, and E.E. El-Fakahany Prolonged inhibition of brain nitric oxide synthase by short-term systemic administration of nitro-l-arginine methyl esther Neurochem. Res. 19 1994 501 505
23. J. Kamei, K. Zushida, K. Morita, M. Sasaki, and S. Tanaka Role of vanilloid VR1 receptor in thermal allodynia and hyperalgesia in diabetic mice Eur. J. Pharmacol. 422 2001 83 86
24. H. Kannan, Y. Hayashida, and H. Yamashita Increase in sympathetic outflow by paraventricular nucleus stimulation in awake rats Am. J. Physiol. 256 1989 R1325 R1330
25. N. Koga, Y. Takano, K. Honda, R. Saito, and H. Kamiya Roles of nitric oxide in the spinal cord in cardiovascular regulation in rats Neurosci. Lett. 267 1999 173 176
26. K.D. Lake, B.R. Martin, G. Kunos, and K. Varga Cardiovascular effects of anandamide in anesthetized and conscious normotensive and hypertensive rats Hypertension 29 1997 1204 1210
27. I.J. Llevellyn-Smith GABA in the control of sympathetic preganglionic neurons Clin. Exp. Pharmacol. Physiol. 29 2002 507 513
28. O.H. Lowry, N.J. Rosenbrough, A.L. Farr, and R.J. Randall Protein measurement with the folin phenol reagent J. Biol. Chem. 193 1951 265 275
29. V.E. Mendizábal, I. Poblete, A. Lomniczi, V. Rettori, J.P. Huidobro-Toro, and E. Adler-Graschinsky Nitric oxide synthase-independent release of nitric oxide induces by KCl in the perfused mesenteric bed of the rat Eur. J. Pharmacol. 409 2000 85 91
30. V.E. Mendizábal, M.L. Orliac, and E. Adler-Graschinsky Long-term inhibition of nitric oxide synthase potentiates effects of anandamide in the rat mesenteric bed Eur. J. Pharmacol. 427 2001 251 262
31. M.A. Morales, K. Holmberg, Z.Q. Xu, C. Cozzari, B.K. Hartman, P. Emson, M. Goldstein, L.G. Elfvin, and T. Hokfelt Localization of choline acetyltransferase in rat peripheral sympathetic neurons and its coexistence with nitric oxide synthase and neuropeptides Proc. Natl. Acad. Sci. U. S. A. 92 1995 11819 11823
32. G.J. Molderings, J. Likungu, and M. Göthert Presynaptic cannabinoid and imidazoline receptors in the human heart and their potential relationship Naunyn-Schmiedeberg's Arch. Pharmacol. 360 1999 157 164
33. J. Németh, Z. Heyles, M. Thán, B. Jakab, E. Pinter, and J. Szolcsányi Concentration-dependent dual effect of anandamide on sensory neuropeptide release from isolated rat tracheae Neurosci. Lett. 336 2003 89 92
34. B.W. Newton, J. Unger, and R.W. Hamill Calcitonin gene-related peptide and somatostatin immunoreactivities in the rat lumbar spinal cord: sexually dimorphic aspects Neuroscience 37 1990 471 489
35. T.J. Price, A. Patwardhan, A.N. Akopian, K.M. Hargreaves, and C.M. Flores Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists anandamide, N-arachidonoyl-dopamine and arachidonoyl-2-chloroethylamide Br. J. Pharmacol. 141 2004 1118 1130
36. M.D. Randall, D. Harris, D.A. Kendall, and V. Ralevic Cardiovascular effects of cannabinoids Pharmacol. Ther. 95 2002 191 202
37. S. Reuss Calcitonin gene-related peptide-like immunoreactivity in spinal cord and superior cervical ganglion of the Djungarian hamster (Phodopus sungorus) J. Chem. Neuroanat. 6 1993 343 350
38. J. Rochford, K. Yashpal, and J.L. Henry Intrathecal administration of calcitonin gene-related peptide (CGRP) increases heart rate and decreases arterial pressure in the urethane anesthetized rat Brain Res. Bull. 25 1990 809 816
39. J.L. Seagard, C. Dean, S. Patel, D.J. Rademacher, F.A. Hopp, W.T. Schmeling, and C.J. Hillard Anandamide content and interaction of endocannabinoid/GABA modulatory effects in the NTS on baroreflex-evoked sympathoinhibition Am. J. Physiol. 286 2004 H992 H1000
40. A. Shimokawa, T. Kunitake, M. Takasaki, and H. Kannan Differential effects of anesthetics on sympathetic nerve activity and arterial baroreceptor reflex in chronically instrumented rats J. Automon. Nerv. Syst. 72 1998 46 54
41. P. Stjarne, L. Lundblad, A. Anggard, T. Hokfelt, and J.M. Lundberg Tachykinins and calcitonin gene-related peptide: co-existence in sensory nerves of the nasal mucosa and effects on blood flow Cell Tissue Res. 256 1989 439 446
42. M. Tognetto, S. Amadesi, S. Harrison, C. Creminon, M. Trevisani, M. Carreras, M. Matera, P. Geppetti, and A. Bianchi Anandamide excites central terminals of dorsal root ganglion neurons via vanilloid receptor-1 activation J. Neurosci. 21 2001 1104 1109
43. S.Y. Wu, and N.J. Dun Presynaptic GABAB receptor activation attenuates synaptic transmission to rat sympathetic preganglionic neurons in vitro Brain Res. 572 1992 94 102
44. K. Yamamoto, E. Senba, T. Matsunaga, and M. Tohyama Calcitonin gene-related peptide containing sympathetic preganglionic and sensory neurons projecting to the superior cervical ganglion of the rat Brain Res. 487 1989 158 164
45. Z. Yang, L. Smith, and J.H. Coote Paraventricular nucleus activation of renal sympathetic neurons is synaptically depressed by nitric oxide and glycine acting at a spinal level Neuroscience 124 2004 421 428
46. Y.P. Yip, L. Rinaman, C. Capriotti, and J.W. Yip Ectopic sympathetic preganglionic neurons maintain proper connectivity in the reeler mutant mouse Neuroscience 118 2003 439 450
47. L. Zhang, A.O. Hoff, S.J. Wimalawansa, G.J. Cote, R.F. Gagel, and K.N. Westlund Arthritic calcitonin/alpha calcitonin gene-related peptide knockout mice have reduced nociceptive hypersensitivity Pain 89 2001 265 273
48. P.M. Zygmunt, J. Petersson, D.A. Andersson, H. Chuang, M. Sorgard, V. Di Marzo, D. Julius, and E.D. Högestätt Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide Nature 400 1999 452 457