TC-2559 excites dopaminergic neurones in the ventral tegmental area by stimulating α4β2-like nicotinic acetylcholine receptors in anaesthetised rats

British Journal of Pharmacology

Volumn 147, Issue 4, 2006, Pages 379-390

  Wang, Yun ^a,b   Sherwood, John L ^a,c   Miles, Colin P ^a   Whiffin, Gary ^a   Lodge, David ^a,c  

^a ELI LILLY AND COMPANY   (United States)

^b CHONGQING TECHNOLOGY AND BUSINESS UNIVERSITY   (China)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Dopaminergic neurone; nAChR; Nicotine; Rat; TC 2559; Ventral tegmental area

Indexed keywords

5' PHENYLSPIRO(1 AZABICYCLO[2.2.2]OCTANE 3,2') (3H)FURO[2,3 B]PYRIDINE; DIHYDRO BETA ERYTHROIDINE; METHYLLYCACONITINE; N METHYL 4 [3 (5 ETHOXYPYRIDIN)YL] 3 BUTEN 1 AMINE DEMIGALACTARATE; NICOTINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; PYRIDINE DERIVATIVE; RECEPTOR SUBUNIT; TC 2559; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BOLUS INJECTION; BRAIN DEPTH STIMULATION; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DOPAMINERGIC TRANSMISSION; DRUG BIOAVAILABILITY; DRUG EFFECT; IN VITRO STUDY; IN VIVO STUDY; MALE; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; RAT; VENTRAL TEGMENTUM;

ACTION POTENTIALS; ANIMALS; APOMORPHINE; DOPAMINE; DOPAMINE AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; LIGANDS; MALE; NEURONS; NICOTINE; NICOTINIC AGONISTS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CHOLINERGIC; RECEPTORS, NICOTINIC; VENTRAL TEGMENTAL AREA;

EID: 33644552135     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706621     Document Type: Article

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