Effects of changing heart rate on electrophysiological and hemodynamic function in the dog

Life Sciences

Volumn 72, Issue 17, 2003, Pages 1919-1930

  Hamlin, Robert L ^a   Nakayama, Tomohiro ^a   Nakayama, Hitomi ^a   Carnes, Cynthia A ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Bradycardia; Cardiovascular effects; Heart rate; Toxicological studies; Zatebradine

Indexed keywords

ATROPINE; ZATEBRADINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA PRESSURE; ARTICLE; CARDIOTOXICITY; CARDIOVASCULAR EFFECT; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG EFFECT; HEART ELECTROPHYSIOLOGY; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE EJECTION TIME; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE; HEART OUTPUT; HEART RATE; HEART RIGHT ATRIUM PRESSURE; HEART STROKE VOLUME; HEMODYNAMICS; NONHUMAN; QT INTERVAL; RIGIDITY; RR INTERVAL; SYSTEMIC VASCULAR RESISTANCE;

CANIS FAMILIARIS;

EID: 0037436747     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(03)00015-8     Document Type: Article

References (31)

1. Atkins C.E., Snyder P.S. Systolic time intervals and their derivatives for evaluation of cardiac function. Journal of Veterinary Internal Medicine. 6:1992;55-63.
2. Bazett H.C. An analysis of the time-relations of electrocardiograms. Heart. 7:1920;353-370.
3. Bell L.B., Peterson D.F. Inotropic responses of the left ventricle to changes in heart rate in anesthetized rabbits. Canadian Journal of Physiology and Pharmacology. 65:1987;179-184.
4. Berne R.M., Levy M.N. Regulation of the heart beat. Berne R.M., Levy M.N. Cardiovascular Physiology. 1997;83-112 Mosby, St. Louis.
5. Bouchard R.A., Bose D. Analysis of the interval-force relationship in rat and canine ventricular myocardium. The American Journal of Physiology. 257:1989;H2036-H2047.
6. Braunwald E., Sonnenblick E.H., Ross J.J. Mechanism of cardiac contraction and relaxation. Braunwald E. Heart Disease. 1992;351-392 WB Sounders, Philadelphia.
7. Breall J.A., Watanabe J., Grossman W. Effect of zatebradine on contractility, relaxation and coronary blood flow. Journal of the American College of Cardiology. 21:1993;471-477.
8. Brown H.F., DiFrancesco D., Noble S.J. How does adrenaline accelerate the heart? Nature. 280:1979;235-236.
9. Chen Z., Slinker B.K. The sinus node inhibitor UL-FS 49 lacks significant inotropic effect. Journal of Cardiovascular Pharmacology. 19:1992;264-271.
10. Chiamvimonvat V., Newman D., Tang A., Green M., Mitchell J., Wulffhart Z., Dorian P. A double-blind placebo-controlled evaluation of the human electrophysiologic effects of zatebradine, a sinus node inhibitor. Journal of Cardiovascular Pharmacology. 32:1998;516-520.
11. Detweiler D.K. The use of electrocardiography in toxicological studies with beagle dogs. Balazs T. Cardiac Toxicology. vol. 3:1981;33-82 CRC Press Inc, Boca Raton.
12. Doerr T., Trautwein W. On the mechanism of the "specific bradycardic action" of the verapamil derivative UL-FS 49. Naunyn-Schmiedeberg's Archives of Pharmacology. 341:1990;331-340.
13. Ezzaher A., Bouanani N.E.H., Crozatier B. Force-frequency relations and response to ryanodine in failing rabbit hearts. The American Journal of Physiology. 263:1992;H1710-H1715.
14. Fridericia L.S. Die sytolendauer in elektrokardiogramm bei normalen menschen und bei herzkranken. Acta Medica Scandinavica. 53:1920;469-486.
15. Goethals M., Raes A., Van Bogaert P.P. Use-dependent block of the pacemaker current If in rabbit sinoatrial node cells by zatebradine (UL-FS49). Circulation. 88:1993;2389-2401.
16. Kambayashi M., Miura T., Oh B.-H., Rockman H.A., Murata K., Ross J. Enhancement of the force-frequency effect on myocardial contractility by adrenergic stimulation in conscious dogs. Circulation. 86:1992;572-580.
17. Kobinger W., Lillie C. Cardiovascular characterization of UL-FS 49, 1,3,4,5-tetrahydro-7,8-dimethoxy-3-[3-][2-(3,4-dimethoxyphenyl)ethyl] methylimino]propyl]-2H-3-benzazepin-2-on hydrochloride, a new "specific bradycardic agent" European Journal of Pharmacology. 104:1984;9-18.
18. Mancini G.B.J., Friedman H.Z., Hramiec J.E., DeBoe S.F. The hemodynamic determinants of the isovolumic index. American Heart Journal. 112:1986;791-799.
19. Mitsuiye T., Shinagawa Y., Noma A. Sustained inward current during pacemaker depolarization in mammalian sinoatrial node cells. Circulation Research. 87:2000;88-91.
20. Mulieri L.A., Hasenfuss G., Leavitt B., Allen P.D., Alpert N.R. Altered myocardial force-frequency relation in human heart failure. Circulation. 85:1992;1743-1750.
21. Munk A.A., Adjemian R.A., Zhao J., Ogbaghebriel A., Shrier A. Electrophyisiological properties of morphologically distinct cells isolated from the rabbit atrioventricular node. Journal of Physiology. 493:1996;801-818.
22. Naito H., Furukawa Y., Chino D., Yamada C., Hashimoto K. Effects of zatebradine and propranolol on canine ischemia and reperfusion-induced arrhythmias. European Journal of Pharmacology. 388:2000;171-176.
23. Neumann T., Ravens U., Heusch G. Characterization of excitation-contraction coupling in conscious dogs with pacing-induced heart failure. Cardiovascular Research. 37:1998;456-466.
24. O'Brien P., Drage D., Saeian K., Brooks H.L., Warltier D.C. Regional redistribution of myocardial perfusion by UL-FS 49, a selective bradycardic agent. American Heart Journal. 123:1992;566-574.
25. Opie L.H. Pacemakers, conduction system, and electrocardiogram. Opie L.H. The Heart Physiology, from Cell to Circulation. 1988;115-124 Lippincott-Raven Publishers, Philadelphia.
26. Pipers F.S., Andrysco R.M., Hamlin R.L. A totally noninvasive method for obtaining systolic time intervals in the dog. American Journal of Veterinary Research. 39:1978;1822-1826.
27. Rouse W., Johnson I.R. Haemodynamic actions of a novel sino-atrial node function modulator, ZENECA ZD7288, in the anaesthetized dog: a comparison with zatebradine, atenolol and nitrendipine. British Journal of Pharmacology. 113:1994;1064-1070.
28. Sakamoto M., Siri F.M., Solomon S.B., Tanimoto H., Yellin E.L. UL-FS 49 (zatebradine) does not affect arterial baroreflex in conscious normal or aortic-contricted rats. Journal of Cardiovascular Pharmacology. 31:1998;488-492.
29. Van de Water A., Verheyen J., Xhonneux R., Reneman R.S. An improved method to correct the QT interval of the electrocardiogram for changes in heart rate. Journal of Pharmacological Methods. 22:1989;207-217.
30. Weiss J.L., Frederiksen J.W., Weisfeldt M.L. Hemodynamic determinants of the time-course of fall in canine left ventricular pressure. Journal of Clinical Investigation. 58:1976;751-760.
31. Yanagihara K., Irisawa H. Inward current activated during hyperpolarization in the rabbit sinoatrial node cell. Pflügers Archiv: European Journal of Physiology. 385:1980;11-19.