Age-related differences in the direct cardiac effects of cisapride: Narrower safety range in the hearts of young rabbits

Pediatric Research

Volumn 53, Issue 3, 2003, Pages 493-499

  Wu, Mei Hwan ^a   Su, Ming Jai ^a   Siu Man Sun, Selma ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIARRHYTHMIC AGENT; CISAPRIDE; DOFETILIDE; KETOCONAZOLE; METHOXAMINE;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATRIOVENTRICULAR BLOCK; CONTROLLED STUDY; DRUG EFFECT; DRUG SAFETY; HEART ATRIOVENTRICULAR NODE; HEART ATRIUM PACING; HEART VENTRICLE TACHYCARDIA; NONHUMAN; PRIORITY JOURNAL; PURKINJE FIBER; RABBIT; REFRACTORY PERIOD; THERMAL CONDUCTIVITY;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; ATRIOVENTRICULAR NODE; BUNDLE OF HIS; CISAPRIDE; ELECTROCARDIOGRAPHY; GASTROINTESTINAL AGENTS; HEART ATRIA; HEART BLOCK; HEART CONDUCTION SYSTEM; LONG QT SYNDROME; PURKINJE FIBERS; RABBITS;

EID: 0037372159     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.PDR.0000050122.67091.1D     Document Type: Article

References (26)

1. Wysowski KD, Bacsanyi J 1996 Cisapride and fatal arrhythmia. N Engl J Med 335:290-291
2. Ahmad SR, Wolfe SM 1995 Cisapride and torsades de pointes. Lancet 345:508
3. Vandenplas Y, Belli DC, Benatar A, Cadranel S, Cucchiara S, Dupont C 1999 The role of cisapride in the treatment of pediatric gastroesophageal reflux. J Pediatr Gastroenterol Nutr 28:518-528
4. Akbarali HI, Thatte H, He XD, Giles WR, Goyal RK 1999 Role of HERG-like K(+) currents in opossum esophageal circular smooth muscle. Am J Physiol 277:C1284-C1290
5. Chen HT, Goh MH, Pan S 1993 The effect and mechanism of the prokinetic action of cisapride on gastrointestinal smooth muscle. Gastroenterol Jpn 28:218-223
6. Puisieux FL, Adamantidis MM, Dumotier BM, Dupuis AB 1996 Cisapride-induced prolongation of cardiac action potential and early afterdepolarizations in rabbit Purkinje fibers. Br J Pharmacol 117:1377-1379
7. Carlsson L, Amos GJ, Andersson B, Drews L, Duker G, Wadstedt G 1997 Electrophysiological characterization of the prokinetic agents cisapride and mosapride in vivo and in vitro: implications for proarrhythmic potential? J Pharmacol Exp Ther 282:220-227
8. Wu MH, Su MJ, Lue HC 1994 Age-related quinidine effects on ionic currents of rabbit cardiac myocytes. J Mol Cell Cardiol 26:1167-1177
9. Kilbon MJ, Fedida D 1990 A study of the developmental changes in outward currents of rat ventricular myocytes. J Physiol 430:37-60
10. Hill SL, Evangelista JK, Pizzi AM, Mobassaleh M, Fulton R, Berul CI 1998 Proarrhythmia associated with cisapride in children. Pediatrics 101:1053-1156
11. Lewin MB, Bryant RM, Fenrich AL, Grifka RG 1996 Cisapride-induced long QT interval. J Pediatr 128:279-281
12. Wu MH, Su MJ, Lee SS, Young ML 1994 The electrophysiological effects of antiarrhythmic potential of a secoaporphine, N-allylsecoboldine. Br J Pharmacol 113:221-227
13. Stevens J 1996 Applied Multivariate Statistics for the Social Sciences, 3rd Ed. Lawrence Erlbaum Associates, New Jersey, pp 450-478
14. Rampe D, Roy ML, Dennis A, Brown AM 1997 A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG. FEBS Lett 417:28-32
15. Wiseman LR, Faulds D 1994 Cisapride. An updated review of its pharmacology and therapeutic efficacy as a prokinetic agent in gastrointestinal motility disorders. Drugs 47:116-152
16. Preechagoon Y, Charles B, Piotrovskij V, Donovan T, Van Peer A 1999 Population pharmacokinetics of enterally administered cisapride in young infants with gastrooesophageal reflux. Br J Clin Pharmacol 48:688-693
17. Drolet B, Khalifa M, Daleau P, Hamelin BA, Turgeon J 1998 Block of the rapid component of the delayed rectifier potassium current by the prokinetic agent cisapride underlies drug-related lengthening of the QT interval. Circulation 97:204-210
18. Walker BD, Singleton CB, Bursill JA, Wyse KR, Valenzuela SM, Qiu MR, Breit SN, Campbell TJ 1999 Inhibition of the human ether-a-go-go-related gene (HERG) potassium channel by cisapride: affinity for open and inactivated states. Br J Pharmacol 128:444-450
19. + current in cardiac myocytes by dofetilide. J Pharmacol Exp Ther 262:809-817
20. + in single cardiac Purkinje cells. Am J Physiol 257:C1086-C1092
21. Nattel S 1999 The molecular and ionic specificity of antiarrhythmic drug actions. J Cardiovasc Electrophysiol 10:272-282
22. Reder RF, Miura DS, Danilo P, Rosen MR 1981 The electrophysiological properties of normal neonatal and adult cardiac Purkinje fibers. Circ Res 48:658-668
23. (+) channel blockers in mice. Am J Physiol 278:C73-C80
24. Wu MH, Su MJ, Lue HC 1993 Postnatal maturation of inwardly rectifying potassium current in isolated ventricular myocytes. J Formos Med Assoc 92:15-9
25. Carlsson L, Abrahamsson C, Andersson B, Duker G, Schiller-Linhardt G 1993 Proarrhythmic effects of the class III antiarrhythmic agent almokalant: importance of infusion rate, QT dispersion and early afterdepolarizations. Cardiovasc Res 27:2186-2193
26. Giles WR, Imaizumi Y 1988 Comparison of potassium currents in rabbit atrial and ventricular cells. J Physiol (Lond) 405:123-145