The effects of an AMPA receptor antagonist on the neurotoxicity of tetracaine intrathecally administered in rabbits

Anesthesia and Analgesia

Volumn 102, Issue 3, 2006, Pages 930-936

  Koizumi, Yumika ^a   Matsumoto, Mishiya ^a   Yamashita, Atsuo ^a   Tsuruta, Shunsuke ^a   Ohtake, Takanao ^a   Sakabe, Takefumi ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; BUPIVACAINE; GLUTAMIC ACID; PENTOBARBITAL; PHENYLEPHRINE; SEVOFLURANE; TETRACAINE; [1,2,3,4 TETRAHYDRO 7 (1H IMIDAZOL 1 YL) 6 NITRO 2,3 DIOXO 1 QUINOXALINYL]ACETIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CEREBROSPINAL FLUID LEVEL; CONTROLLED STUDY; CYTOPLASM; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; EVALUATION; HISTOPATHOLOGY; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NEUROTOXICITY; NISSL SUBSTANCE; NONHUMAN; PRIORITY JOURNAL; SENSORY DYSFUNCTION; SENSORY NERVE;

EID: 33644502539     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ane.0000195550.67356.6a     Document Type: Article

References (20)

1. Rigler ML, Drasner K, Krejcie TC, et al. Cauda equina syndrome after continuous spinal anesthesia. Anesth Analg 1991;72: 275-81.
2. Ready LB, Plumer MH, Haschke RH, et al. Neurotoxicity of intrathecal local anesthetics in rabbits. Anesthesiology 1985;63: 364-70.
3. Drasner K, Sakura S, Chan VWS, et al. Persistent sacral sensory deficit induced by intrathecal local anesthetic infusion in the rat. Anesthesiology 1994;80:847-52.
4. Gold MS, Reichling DB, Hampl KF, et al. Lidocaine toxicity in primary afferent neurons from the rat. J Pharmacol Exp Ther 1998;285:413-21.
5. Johnson ME, Saenz JA, DaSilva AD, et al. Effect of local anesthetic on neuronal cytoplasmic calcium and plasma membrane lysis (necrosis) in a cell culture model. Anesthesiology 2002;97: 1466-76.
6. Kitagawa N, Oda M, Totoki T. Possible mechanism of irreversible nerve injury caused by local anesthetics: detergent properties of local anesthetics and membrane disruption. Anesthesiology 2004;100:962-7.
7. Ohtake K, Matsumoto M, Wakamatsu H, et al. Glutamate release and neuronal injury after intrathecal injection of local anesthetics. Neuro Report 2000;11:1105-9.
8. Oka S, Matsumoto M, Ohtake K, et al. The addition of epinephrine to tetracaine injected intrathecally sustains an increase in glutamate concentrations in the cerebrospinal fluid and worsens neuronal injury. Anesth Analg 2001;93:1050-7.
9. Yamashita A, Matsumoto M, Matsumoto S, et al. A comparison of the neurotoxic effects on the spinal cord of tetracaine, lidocaine, bupivacaine, and ropivacaine administered intrathecally in rabbits. Anesth Analg 2003;97:512-9.
10. Li S, Stys PK. Mechanisms of ionotropic glutamate receptor-mediated excitotoxicity in isolated spinal cord white matter. J Neurosci 2000;20:1190-8.
11. Wakamatsu H, Matsumoto M, Nakakimura K, Sakabe T. The effects of moderate hypothermia and intrathecal tetracaine on glutamate concentrations of intrathecal dialysate and neurologic and histopathologic outcome in transient spinal cord ischemia in rabbits. Anesth Analg 1999;88:56-62.
12. Nishiyama T, Gyermek L, Lee C, et al. Analgesic interaction between intrathecal midazolam and glutamate receptor antagonists on thermal-induced pain in rats. Anesthesiology 1999;91: 531-7.
13. Drummond JC, Moore SS. The influence of dextrose administration on neurologic outcome after temporary spinal cord ischemia in the rabbit. Anesthesiology 1989;70:64-70.
14. Kaneko S, Matsumoto M, Tsuruta S, et al. The nerve root entry zone is highly vulnerable to intrathecal tetracaine in rabbits. Anesth Analg 2005;101:107-14.
15. Hudspith MJ. Glutamate: a role in normal brain function, anaesthesia, analgesia and CNS injury. Br J Anaesth 1997;78: 731-47.
16. Sarantis M, Everett K, Attwell D. A presynaptic action of glutamate at the cone output synapse. Nature 1988;332:451-3.
17. Martin D, Bustos GA, Bowe MA, et al. Autoreceptor regulation of glutamate and aspartate release from slices of the hippocampal CA1 area. J Neurochem 1991;56:1647-55.
18. Takenami T, Yagishita S, Asato F, Hoka S. Neurotoxicity of intrathecally administered tetracaine commences at the posterior roots near entry into the spinal cord. Reg Anesth Pain Med 2000;25:372-9.
19. Takahashi M, Kohara A, Shishikura J, et al. YM872: a selective, potent and highly water-soluble alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist. CNS Drug Rev 2002;8:337-52.
20. Nishiyama T, Gyermek L, Lee C, et al. The spinal antinociceptive effects of a novel competitive AMPA receptor antagonist, YM872, on thermal or formalin-induced pain in rats. Anesth Analg 1999;89:143-7.