The nerve root entry zone is highly vulnerable to intrathecal tetracaine in rabbits

Anesthesia and Analgesia

Volumn 101, Issue 1, 2005, Pages 107-114

  Kaneko, Shuichi ^a   Matsumoto, Mishiya ^a   Tsuruta, Shunsuke ^a   Hirata, Takao ^a   Gondo, Toshikazu ^a   Sakabe, Takefumi ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETIC AGENT; TETRACAINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAUDA EQUINA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENTAL ANESTHESIA; DORSAL ROOT; HISTOPATHOLOGY; LOCAL ANESTHESIA; MORPHOLOGICAL TRAIT; MYELIN SHEATH; NERVE ROOT; NEUROLOGIC DISEASE; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RABBIT; SPINAL CORD; VENTRAL ROOT;

ANESTHETICS, LOCAL; ANIMALS; CATHETERIZATION; CAUDA EQUINA; GANGLIA, SPINAL; MOTOR NEURONS; MYELIN SHEATH; NERVE DEGENERATION; NERVE FIBERS; NEURONS, AFFERENT; OLIGODENDROGLIA; RABBITS; SPINAL NERVE ROOTS; TETRACAINE;

EID: 20744447736     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000153018.90619.65     Document Type: Article

References (18)

1. Auroy Y, Narchi P, Messiah A, et al. Serious complications related to regional anesthesia: results of a prospective survey in France. Anesthesiology 1997;87:479-86.
2. Adams HJ, Mastri AR, Eicholzer AW, Kilpatrick G. Morphologic effects of intrathecal etidocaine and tetracaine on the rabbit spinal cord. Anesth Analg 1974;53:904-8.
3. Ready LB, Plumer MH, Haschke RH, et al. Neurotoxicity of intrathecal local anesthetics in rabbits. Anesthesiology 1985;63:364-70.
4. Drasner K, Sakura S, Chan VWS, et al. Persistent sacral sensory deficit induced by intrathecal local anesthetic infusion in the rat. Anesthesiology 1994;80:847-52.
5. Takenami T, Yagishita S, Asato F, Hoka S. Neurotoxicity of intrathecally administered tetracaine commences at the posterior roots near entry into the spinal cord. Reg Anesth Pain Med 2000;25:372-9.
6. Ohtake K, Matsumoto M, Wakamatsu H, et al. Glutamate release and neuronal injury after intrathecal injection of local anesthetics. Neuroreport 2000;11:1105-9.
7. Hashimoto K, Sakura S, Bollen AW, et al. Comparative toxicity of glucose and lidocaine administered intrathecally in the rat. Reg Anesth Pain Med 1998;23:444-50.
8. Oka S, Matsumoto M, Ohtake K, et al. The addition of epinephrine to tetracaine injected intrathecally sustains an increase in glutamate concentrations in the cerebrospinal fluid and worsens neuronal injury. Anesth Analg 2001;93:1050-7.
9. Yamashita A, Matsumoto M, Matsumoto S, et al. A comparison of the neurotoxic effects on the spinal cord of tetracaine, lidocaine, bupivacaine, and ropivacaine administered intrathecally in rabbits. Anesth Analg 2003;97:512-9.
10. Drummond JC, Moore SS. The influence of dextrose administration on neurologic outcome after temporary spinal cord ischemia in the rabbit. Anesthesiology 1989;70:64-70.
11. Sekiya T, Moller AR, Jannetta PJ. Pathophysiological mechanisms of intraoperative and postoperative hearing deficits in cerebellopontine angle surgery: an experimental study. Acta Neurochir (Wien) 1986;81:142-51.
12. Sekiya T, Moller AR. Cochlear nerve injuries caused by cerebellopontine angle manipulations. An electrophysiological and morphological study in dogs. J Neurosurg 1987;67:244-9.
13. Nemecek S, Parizek J, Spacek J, Nemeckova J. Histological, histochemical and ultrastructural appearance of the transitional zone of the cranial and spinal nerve roots. Folia Morphol (Praha) 1969;17:171-81.
14. McDonald JW, Althomsons SP, Hyrc KL, et al. Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity. Nature Med 1998;4:291-7.
15. Schneider M, Ettlin T, Kaufmann M, et al. Transient neurologic toxicity after hyperbaric subarachnoid anesthesia with 5% lidocaine. Anesth Analg 1993;76:1154-7.
16. Hampl KF, Heinzmann-Wiedmer S, Luginbuehl I, et al. Transient neurologic symptoms after spinal anesthesia. Anesthesiology 1998;88:629-33.
17. Freedman JM, Li DK, Drasner K, et al. Transient neurologic symptoms after spinal anesthesia: an epidemiologic study of 1,863 patients. Anesthesiology 1998;89:633-41.
18. Hirabayashi Y, Igarashi T, Suzuki H, et al. Mechanical effects of leg position on vertebral structures examined by magnetic resonance imaging. Reg Anesth Pain Med 2002;27:429-32.