Up-regulation of endothelin receptor function and mRNA expression in airway smooth muscle cells following Sephadex-induced airway inflammation

Basic and Clinical Pharmacology and Toxicology

Volumn 95, Issue 1, 2004, Pages 43-48

  Granström, Bengt W ^a   Xu, Cang Bao ^a   Nilsson, Elisabet ^a   Bengtsson, Ursula Hultkvist ^b   Edvinsson, Lars ^a,c  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN RECEPTOR; ENFLURANE; SARAFOTOXIN S6C; SEPHADEX;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS HYPERREACTIVITY; BRONCHUS MUSCLE; CONTROLLED STUDY; ENDOTHELIN RECEPTOR TYPE B GENE; GENE; GENE EXPRESSION; INFLAMMATION; MALE; MYOGRAPHY; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; RNA ANALYSIS; TRACHEA MUSCLE;

ANIMALS; BRONCHI; DEXTRANS; ENDOTHELIN-1; INFLAMMATION; MALE; MYOCYTES, SMOOTH MUSCLE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRACHEA; UP-REGULATION; VIPER VENOMS;

ANIMALIA; BRONCHUS;

EID: 3342989772     PISSN: 17427835     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2004.pto950109.x     Document Type: Article

References (30)

1. Andersson, S. E., S. Eirefelt, C. Zackrisson, A. Hemsen, M. Dahlback & J. M. Lundberg: Regulatory effects of aerosolized budesonide and adrenalectomy on the lung content of endothelin-1 in the rat. Respiration 1995, 62, 34-39.
2. Andersson, S. E., A. Hemsen, C. Zackrisson & J. M. Lundberg: Release of endothelin-I into rat airways following Sephadex-induced inflammation; modulation by enzyme inhibitors and budesonide. Respiration 1996, 63, 111-116.
3. Andersson, S. E., C. Zackrisson, A. Hemsen & J. M. Lundberg: Regulation of lung endothelin content by the glucocorticosteroid budesonide. Biochem. Biophys. Res. Commun. 1992, 188, 1116-1121.
4. Candenas, M. L., E. Naline, B. Sarria & C. Advenier: Effect of epithelium removal and of enkephalin inhibition on the bronchoconstrictor response to three endothelins of the human isolated bronchus. Eur. J. Pharmacol. 1992, 210, 291-297.
5. Chalmers, G. W., L. Thomson, K. J. Macleod, K. D. Dagg, B. J. McGinn, C. McSharry, K. R. Patel & N. C. Thomson: Endothelin-1 levels in induced sputum samples from asthmatic and normal subjects. Thorax 1997b, 52, 625-627.
6. Chalmers, G. W., S. A. Little, K. R. Patel & N. C. Thomson: Endothelin-1-induced bronchoconstriction in asthma. Amer. J. Respir. Crit. Care Med. 1997a, 156, 382-388.
7. Finsnes, F., G. Christensen, T. Lyberg, O. M. Sejersted & O. H. Skjonsberg: Increased synthesis and release of endothelin-1 during the initial phase of airway inflammation. AmER. J. Respir. Crit. Care Med. 1998, 158, 1600-1606.
8. Fukuroda, T., T. Fujikawa, S. Ozaki, K. Ishikawa, M. Yano & M. Nishikibe: Clearance of circulating endothelin-1 by ETB receptors in rats. Biochem. Biophys. Res. Commun. 1994, 199, 1461-1465.
9. Goldie, R. G., A. C. D'Aprile, G. J. Self, P. J. Rigby & P. J. Henry: The distribution and density of receptor subtypes for endothelin-1 in peripheral lung of the rat, guinea-pig and pig. Brit. J. Pharmacol. 1996, 117, 729-735.
10. Goldie, R. G., P. J. Henry, P. G. Knott, G. J. Self, M. A. Luttmann & D. W. Hay: Endothelin-I receptor density, distribution, and function in human isolated asthmatic airways. Amer. J. Respir. Crit. Care Med. 1995, pp. 1653-1658.
11. Granström, B., E. Nilsson, U. Hultkvist-Bengtsson & L. Edvinsson: Analysis of ET-A and ET-B receptors using an isolated perfused rat lung preparation. Acta physiol. scand 2004 (in press).
12. Hadj Kaddour, K., A. Michel & C. Chevillard: Endothelin-1 and endothelin-3 relax isolated guinea pig trachea through different mechanisms. J. Cardiovasc. Pharmacol. 1995, 26, Suppl 3, S115-S116.
13. Hakonarson, H., E. Halapi, R. Whelan, J. Gulcher, K. Stefansson & M. M. Grunstein: Association between IL-1beta/TNF-alpha-induced glucocorticoid-sensitive changes in multiple gene expression and altered responsiveness in airway smooth muscle. Amer. J. Respir. Cell Mol. Biol. 2001, 25, 761-771.
14. Henriksson, M., E. Stenman & L. Edvinsson: Intracellular pathways involved in upregulation of vascular endothelin type B receptors in cerebral arteries of the rat. Stroke 2003, 34, 1479-1483.
15. Henry, P. J.: Endothelin-1 (ET-1)-induced contraction in rat isolated trachea: involvement of ETA and ETB receptors and multiple signal transduction systems. Brit. J. Pharmacol. 1993, 110, 435-441.
16. Högestätt, E. D., K. E. Andersson & L. Edvinsson: Mechanical properties of rat cerebral arteries as studied by a sensitive device for recording of mechanical activity in isolated small blood vessels. Acta physiol. scand. 1983, 117, 49-61.
17. Laitinen, L. A., A. Laitinen & T. Haahtela: Airway mucosal inflammation even in patients with newly diagnosed asthma. Amer. Rev. Respir. Dis. 1993, 147, 697-704.
18. Leseth, K. H., M. Adner, H. K. Berg, L. R. White, J. Aasly & L. Edvinsson: Cytokines increase endothelin ETB receptor contractile activity in rat cerebral artery. Neuroreport 1999, 10, 2355-2359.
19. Michael, J. R. & B. A. Markewitz: Endothelins and the lung. Amer. J. Respir. Crit. Care Med. 1996, 154, 555-581.
20. Möller, S., M. Adner & L. Edvinsson: Increased levels of endothelin ETB receptor mRNA in human omental arteries after organ culture: quantification by competitive reverse transcription-polymerase chain reaction. Clin. Exp. Pharmacol. Physiol. 1998, 25, 788-794.
21. Möller, S., L. Edvinsson & M. Adner: Transcriptional regulated plasticity of vascular contractile endothelin ET(B) receptors after organ culture. Eur. J. Pharmacol. 1997, 329, 69-77.
22. Möller, S., R. Uddman, B. Granström & L. Edvinsson: Altered ratio of endothelin ET(A)- and ET(B) receptor mRNA in bronchial biopsies from patients with asthma and chronic airway obstruction. Eur. J. Pharmacol. 1999, 365, R1-R3.
23. Naline, E., C. Bertrand, K. Biyah, Y. Fujitani, T. Okada, A. Bisson & C. Advenier: Modulation of ET-1-induced contraction of human bronchi by airway epithelium-dependent nitric oxide release via ET(A) receptor activation. Brit. J. Pharmacol. 1999, 126, 529-535.
24. Uddman, E., M. Adner & L. Edvinsson: Protein kinase C inhibitors decrease endothelin ET(B) receptor mRNA expression and contraction during organ culture of rat mesenteric artery. Eur. J. Pharmacol. 2002, 452, 215-222.
25. Uddman, E., M. Henriksson, K. Eskesen & L. Edvinsson: Role of mitogen-activated protein kinases in endothelin ETB receptor upregulation after organ culture of rat mecenteric artery. Eur. J. Pharmacol. 2003, 482, 39-47.
26. Uddman, E., S. Möller, M. Adner & L. Edvinsson: Cytokines induce increased endothelin ET(B) receptor-mediated contraction. Eur. J. Pharmacol. 1999, 376, 223-232.
27. White, L. R., K. H. Leseth, S. Möller, R. Juul, M. Adner, J. Cappelen, G. Bovim, J. Aasly & L. Edvinsson: Interleukin-1beta potentiates endothelin ET(B) receptor-mediated contraction in cultured segments of human temporal artery. Regul. Pept. 1999, 81, 89-95.
28. Williams, D. L., Jr., K. L. Jones, D. J. Pettibone, E. V. Lis & B. V. Clineschmidt: Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes. Biochem. Biophys. Res. Commun. 1991, 175, 556-561.
29. Vittori, E., M. Marini, A. Fasoli, R. De Franchis & S. Mattoli: Increased expression of endothelin in bronchial epithelial cells of asthmatic patients and effect of corticosteroids. Amer. Rev. Respir. Dis. 1992, 146, 1320-1325.
30. Yang, Q., J. Laporte, B. Battistini & P. Sirois: Effects of dexamethasone on the basal and cytokine-stimulated release of endothelin-1 from guinea-pig cultured tracheal epithelial cells. Can. J. Physiol. Pharmacol. 1997, 75, 576-581.