Analysis of ET-A and ET-B receptors using an isolated perfused rat lung preparation

Acta Physiologica Scandinavica

Volumn 181, Issue 2, 2004, Pages 259-264

  Granstrom B ^a   Nilsson, E ^a   Hultkvist Bengtsson, U ^b   Edvinsson, L ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Bosentan; BQ 788; Endothelin 1; ETA receptor; ETB receptor; FR 139317; Rat bronchus

Indexed keywords

2 [[2 [[2 [[(HEXAHYDRO 1H AZEPIN 1 YL)CARBONYL]AMINO] 4 METHYLPENTANOYL]AMINO] 3 (1 METHYL 1H INDOL 3 YL)PROPIONYL]AMINO] 3 (2 PYRIDYL)PROPIONIC ACID; BOSENTAN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR; ENDOTHELIN B RECEPTOR ANTAGONIST; ENDOTHELIN RECEPTOR AGONIST; ENDOTHELIN RECEPTOR ANTAGONIST; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; SARAFOTOXIN S6C;

AIRWAY CONDUCTANCE; ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; DRUG RESPONSE; FLOW; ISOLATED LUNG; LUNG PERFUSION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; VASOCONSTRICTION;

ANIMALS; ANTIHYPERTENSIVE AGENTS; AZEPINES; BRONCHI; ENDOTHELIN-1; INDOLES; LUNG; MALE; OLIGOPEPTIDES; ORGAN CULTURE TECHNIQUES; PERFUSION; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; SULFONAMIDES; VASOCONSTRICTOR AGENTS; VIPER VENOMS;

EID: 3042606228     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-201X.2004.01275.x     Document Type: Article

References (27)

1. Adner, M., Cardell, L.O., Sjöberg, T., Ottosson, A. & Edvinsson, L. 1996. Contractile endothelin-B (ETB) receptors in human small bronchi. Eur Respir J 9, 351-355.
2. Adner, M., Uddman, E., Cardell, L.O. & Edvinsson, L. 1998. Regional variation in appearance of vascular contractile endothelin-B receptors following organ culture. Cardiovasc Res 37, 254-262.
3. Arai, H., Hori, S., Aramori, I., Ohkubo, H. & Nakanishi, S. 1990. Cloning and expression of a cDNA encoding an endothelin receptor. Nature 348, 730-732.
4. Bonvallet, S.T., Oka, M., Yano, M., Zamora, M.R., McMurtry, I.F. & Stelzner, T.J. 1993. BQ123, an ETA receptor antagonist, attenuates endothelin-1-induced vasoconstriction in rat pulmonary circulation. J Cardiovasc Pharmacol 22, 39-43.
5. Cardell, L.O., Uddman, R. & Edvinsson, L. 1990. Analysis of endothelin-1-induced contractions of guinea-pig trachea, pulmonary veins and different types of pulmonary arteries. Acta Physiol Scand 139, 103-111.
6. Cardell, L.O., Uddman, R. & Edvinsson, L. 1993. A novel ETA-receptor antagonist, FR 139317, inhibits endothelin-induced contractions of guinea-pig pulmonary arteries, but not trachea. Br J Pharmacol 108, 448-452.
7. Clozel, M., Breu, V., Gray, G.A. et al. 1994. Pharmacological characterization of Bosentan, a new potent orally active nonpeptide endothelin receptor antagonist. J Pharmacol Exp Ther 270, 228-235.
8. Goldie, R.G., Knott, P.G., Carr, M.J., Hay, D.W. & Henry, P.J. 1996. The endothelins in the pulmonary system. Pulm Pharmacol 9, 69-93.
9. Granstrom, B., Adner, M., Uddman, R., Edvinsson, L. & Cardell, L.O. 1997. Characterisation of endothelin induced relaxation in guinea-pig airways: evidence for dilatory ETA-and ETB-receptors. Pulm Pharmacol Ther 10, 293-298.
10. Granström, B., Xu, C.-B., Nilsson, E., Hultkvist-Bengtsson, U. & Edvinsson, L. 2004. Up-regulation of endothelin receptor function and mRNA expression in airway smooth muscle cells following Sephadex-induced airway inflammation. Pharmacol Toxicol (in press).
11. Henry, P.J. 1993. Endothelin-1 (ET-1)-induced contraction in rat isolated trachea: involvement of ETA and ETB receptors and multiple signal transduction systems. Br J Pharmacol 110, 435-441.
12. Ishikawa, K., Ihara, M., Noguchi, K. et al. 1994. Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788. Proc Natl Acad Sci U S A 91, 4892-4896.
13. Lal, H., Woodward, B. & Williams, K.I. 1995. Actions of endothelins and sarafotoxin 6c in the rat isolated perfused lung. Br J Pharmacol 115, 653-659.
14. MacLean, M.R., McCulloch, K.M. & Baird, M. 1994. Endothelin ETA- and ETB-receptor-mediated vasoconstriction in rat pulmonary arteries and arterioles. J Cardiovasc Pharmacol 23, 838-845.
15. Masaki, T., Yanagisawa, M. & Goto, K. 1992. Physiology and pharmacology of endothelins. Med Res Rev 12, 391-421.
16. Mattoli, S., Mezzetti, M., Riva, G., Allegra, L. & Fasoli, A. 1990. Specific binding of endothelin on human bronchial smooth muscle cells in culture and secretion of endothelin-like material from bronchial epithelial cells. Am J Respir Cell Mol Biol 3, 145-151.
17. Möller, S., Edvinsson, L. & Adner, M. 1997. Transcriptional regulated plasticity of vascular contractile endothelin ET(B) receptors after organ culture. Eur J Pharmacol 329, 69-77.
18. O'Donnell, S.R. & Kay, C.S. 1995. Effects of endothelin receptor selective antagonists, BQ-123 and BQ-788, on IRL 1620 and endothelin-1 responses of airway and vascular preparations from rats. Pulm Pharmacol 8, 11-19.
19. Redington, A.E., Springall, D.R., Ghatei, M.A. et al. 1995. Endothelin in bronchoalveolar lavage fluid and its relation to airflow obstruction in asthma. Am J Respir Crit Care Med 151, 1034-1039.
20. Rozengurt, N., Springall, D.R. & Polak, J.M. 1990. Localization of endothelin-like immunoreactivity in airway epithelium of rats and mice. J Pathol 160, 5-8.
21. Sakurai, T., Yanagisawa, M., Takuwa, Y. et al. 1990. Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor [see comments]. Nature 348, 732-735.
22. Shennib, H., Lee, A.G., Kuang, J.Q., Yanagisawa, M., Ohlstein, E.H. & Giaid, A. 1998. Efficacy of administering an endothelin-receptor antagonist (SB209670) in ameliorating ischemia-reperfusion injury in lung allografts. Am J Respir Crit Care Med 157, 1975-1981.
23. Szok, D., Hansen-Schwartz, J. & Edvinsson, L. 2001. In-depth pharmacological characterization of endothelin B receptors in the rat middle cerebral artery. Neurosci Lett 314, 69-72.
24. Uhlig, S., von Bethmann, A.N., Featherstone, R.L. & Wendel, A. 1995. Pharmacologic characterization of endothelin receptor responses in the isolated perfused rat lung. Am J Respir Crit Care Med 152, 1449-1460.
25. Vittori, E., Marini, M., Fasoli, A., De Franchis, R. & Mattoli, S. 1992. Increased expression of endothelin in bronchial epithelial cells of asthmatic patients and effect of corticosteroids. Am Rev Respir Dis 146, 1320-1325.
26. Westcott, J.Y., Henson, J., McMurtry, I.F. & O'Brien, R.F. 1990. Uptake and metabolism of endothelin in the isolated perfused rat lung. Exp Lung Res 16, 521-532.
27. Yanagisawa, M., Kurihara, H., Kimura, S. et al. 1988. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332, 411-415.