The effects of uncoupling protein-1 genotype on lipoprotein cholesterol level in Korean obese subjects

Metabolism: Clinical and Experimental

Volumn 53, Issue 8, 2004, Pages 1054-1059

  Oh, Hyun Hee ^a   Kim, Kil Soo ^b   Choi, Sun Mi ^a   Yang, Hyun Sung ^a   Yoon, Yoosik ^a,c  

^a Korea Institute of Oriental Medicine (KIOM)   (South Korea)

^b Kirin Oriental Medical Hospital   (South Korea)

^c Yuseong gu 305 811 ^*  (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 1;

ADULT; ARTICLE; BODY COMPOSITION; BODY DISTRIBUTION; BODY HEIGHT; BODY MASS; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; CORONARY RISK; DIABETIC OBESITY; DIASTOLIC BLOOD PRESSURE; DNA POLYMORPHISM; FEMALE; FISHER EXACT TEST; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE PHENOTYPE CORRELATION; GLUCOSE BLOOD LEVEL; HUMAN; HYPERCHOLESTEROLEMIA; LIPOPROTEIN BLOOD LEVEL; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; BLOOD GLUCOSE; BLOOD PRESSURE; BODY COMPOSITION; BODY MASS INDEX; BODY WEIGHT; CARRIER PROTEINS; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; HYPERCHOLESTEROLEMIA; ION CHANNELS; KOREA; LIPOPROTEINS; LIVER FUNCTION TESTS; LOGISTIC MODELS; MALE; MEMBRANE PROTEINS; MITOCHONDRIAL PROTEINS; OBESITY; POLYMORPHISM, GENETIC;

EID: 3342964198     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2004.02.014     Document Type: Article

References (37)

1. Lean M.E. Brown adipose tissue in humans. Proc Nutr Soc. 48:1989;243-256
2. Klaus S., Casteilla L., Bouillaud F., et al. The uncoupling protein UCP A membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue. Int J Biochem. 23:1991;791-801
3. Bouillaud F., Couplan E., Pecqueur C., et al. Homologues of the uncoupling protein from brown adipose tissue (UCP-1) UCP2, UCP3, BMCP1 and UCP4. Biochim Biophys Acta. 1:2001;107-119
4. Ravussin E., Lillioja S., Knowler W.C., et al. Reduced rate of energy expenditure as a risk factor for body-weight gain. N Engl J Med. 318:1988;467-472
5. Nagase I., Yoshida T., Kumamoto K., et al. Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic beta 3-adrenergic agonist. J Clin Invest. 97:1996;2898-2904
6. Garruti G., Ricquier D. Analysis of uncoupling protein and its mRNA in adipose tissue deposits of adult humans. Int J Obes Relat Metab Disord. 16:1992;383-390
7. Esterbauer H., Oberkofler H., Liu Y.M., et al. Uncoupling protein-1 mRNA expression in obese human subjects The role of sequence variations at the uncoupling protein-1 gene locus. J Lipid Res. 39:1998;834-844
8. Clement K., Ruiz J., Cassard-Doulcier A.M., et al. Additive effect of A→G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity. Int J Obes Relat Metab Disord. 20:1996;1062-1066
9. Shihara N., Yasuda K., Moritani T., et al. Synergistic effects of polymorphisms of uncoupling protein 1 and beta3-adrenergic receptor genes on autonomic nervous system activity. Int J Obes Relat Metab Disord. 25:2001;761-766
10. Cassard A.M., Bouillaud F., Mattei M.G., et al. Human uncoupling protein gene structure, comparison with rat gene, and assignment to the long arm of chromosome 4. J Cell Biochem. 43:1990;255-264
11. Oppert J.M., Vohl M.C., Chagnon M., et al. DNA polymorphism in the uncoupling protein (UCP) gene and human body fat. Int J Obes Relat Metab Disord. 18:1994;526-531
12. Kogure A., Yoshida T., Sakane N., et al. Synergic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on weight loss in obese Japanese. Diabetologia. 41:1998;1399. (letter)
13. Fumeron F., Durack-Bown I., Betoulle D., et al. Polymorphisms of uncoupling protein (UCP) and beta 3 adrenoreceptor genes in obese people submitted to a low calorie diet. Int J Obes Relat Metab Disord. 20:1996;1051-1054
14. Sivenius K., Valve R., Lindi V., et al. Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on long-term body weight change in Finnish type 2 diabetic and non-diabetic control subjects. Int J Obes Relat Metab Disord. 24:2000;514-519
15. Heilbronn L.K., Kind K.L., Pancewicz E., et al. Association of -3826 G variant in uncoupling protein-1 with increased BMI in overweight Australian women. Diabetologia. 43:2000;242-244
16. Hayakawa T., Nagai Y., Taniguchi M., et al. Phenotypic characterization of the beta3-adrenergic receptor mutation and the uncoupling protein 1 polymorphism in Japanese men. Metabolism. 48:1999;636-640
17. Proenza A.M., Poissonnet C.M., Ozata M., et al. Association of sets of alleles of genes encoding beta3-adrenoreceptor, uncoupling protein 1 and lipoprotein lipase with increased risk of metabolic complications in obesity. Int J Obes Relat Metab Disord. 24:2000;93-100
18. Herrmann S.M., Wang J.G., Staessen J.A., et al. Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio. J Mol Med. 81:2003;327-332
19. Fogelholm M., Valve R., Kukkonen-Harjula K., et al. Additive effects of the mutations in the beta3-adrenergic receptor and uncoupling protein-1 genes on weight loss and weight maintenance in Finnish women. J Clin Endocrinol Metab. 83:1998;4246-4250
20. Pihlajamaki J., Rissanen J., Valve R., et al. Different regulation of free fatty acid levels and glucose oxidation by the Trp64Arg polymorphism of the beta3-adrenergic receptor gene and the promoter variant (A-3826G) of the uncoupling protein 1 gene in familial combined hyperlipidemia. Metabolism. 47:1998;1397-1402
21. Indicator of Clinical Pathology. Ed 8 :1999;76-78 Seoul National University Hospital, Seoul, Korea
22. Valve R., Heikkinen S., Rissanen A., et al. Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on basal metabolic rate in obese Finns. Diabetologia. 41:1998;357-361
23. Schaffler A., Palitzsch K.D., Watzlawek E., et al. Frequency and significance of the A→G (-3826) polymorphism in the promoter of the gene for uncoupling protein-1 with regard to metabolic parameters and adipocyte transcription factor binding in a large population-based Caucasian cohort. Eur J Clin Invest. 29:1999;770-779
24. Urhammer S.A., Fridberg M., Sorensen T.I., et al. Studies of genetic variability of the uncoupling protein 1 gene in Caucasian subjects with juvenile-onset obesity. J Clin Endocrinol Metab. 82:1997;4069-4074
25. Gagnon J., Lago F., Chagnon Y.C., et al. DNA polymorphism in the uncoupling protein 1 (UCP-1) gene has no effect on obesity related phenotypes in the Swedish obese subjects cohorts. Int J Obes Relat Metab Disord. 22:1998;500-505
26. The Asia-Pacific Perspective Redefining Obesity and its Treatment. 2000;WHO Western Pacific Region, International Association for the Study of Obesity, International Obesity Task Force, Manila, Phillipines
27. Matsushita H., Kurabayashi T., Tomita M., et al. Effects of uncoupling protein 1 and beta3-adrenergic receptor gene polymorphisms on body size and serum lipid concentrations in Japanese women. Maturitas. 45:2003;39-45
28. Walston J., Silver K., Bogardus C., et al. Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene. N Engl J Med. 333:1995;343-347
29. Higuchi M., Hashimoto I., Yamakawa K., et al. Effect of exercise training on plasma high-density lipoprotein cholesterol level at constant weight. Clin Physiol. 4:1984;125-133
30. Ferguson M.A., Alderson N.L., Trost S.G., et al. Plasma lipid and lipoprotein responses during exercise. Scand J Clin Lab Invest. 63:2003;73-79
31. Jensen M.D., Haymond M.W., Rizza R.A., et al. Influence of body fat distribution on free fatty acid metabolism in obesity. J Clin Invest. 83:1989;1168-1173
32. Benthem L., Kuipers F., Steffens A.B., et al. Excessive portal venous supply of long-chain free fatty acids to the liver, leading to hypothalamus-pituitary-adrenal-axis and sympathetic activation as a key to the development of syndrome X. A proposed concept for the induction of syndrome X. Ann NY Acad Sci. 892:1999;308-311
33. Raspe E., Madsen L., Lefebvre A.M., et al. Modulation of rat liver apolipoprotein gene expression and serum lipid levels by tetradecylthioacetic acid (TTA) via PPARalpha activation. J Lipid Res. 40:1999;2099-2110
34. Djouadi F., Brandt J.M., Weinheimer C.J., et al. The role of the peroxisome proliferator-activated receptor alpha (PPAR alpha) in the control of cardiac lipid metabolism. Prostaglandins Leukot Essent Fatty Acids. 60:1999;339-343
35. Jump D.B., Clarke S.D. Regulation of gene expression by dietary fat. Annu Rev Nutr. 19:1999;63-90
36. Kim S.G., Kim C.H., Yun S.K., et al. Polymorphism of the uncoupling protein-1 (UCP-1) gene and fatty acid binding protein-2 (FABP-2) gene in Korean type II diabetic patients. J Korean Diabetic Assoc. 25:2001;262-272
37. Kim J.H., Yun S.K., Kim C.H., et al. Association between uncoupling protein-1 and 3-adrenergic receptor gene polymorphism and energy metabolism in normal Korean adults. J Korean Diabetic Assoc. 23:1999;803-813