Effects of sex steroid receptor specificity in the regulation of skeletal metabolism

Calcified Tissue International

Volumn 75, Issue 1, 2004, Pages 60-70

  Tozum T F ^a,b   Oppenlander, M E ^a,c   Koh Paige, A J ^a   Robins, D M ^c   McCauley, L K ^a,c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b HACETTEPE UNIVERSITY   (Turkey)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Androgen; Androgen receptor; Bone; Estrogen; Estrogen receptor; Osteoblast; Parathyroid hormone

Indexed keywords

ADENYLATE CYCLASE; ANDROGEN RECEPTOR; CALCIUM; CYCLIC AMP; DNA; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; HORMONE RECEPTOR; PARATHYROID HORMONE; SEX HORMONE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE METABOLISM; BONE MINERAL; CELL DIFFERENTIATION; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; GENOTYPE; MALE; MICRORADIOGRAPHY; MORPHOMETRICS; MOUSE; NONHUMAN; OSTEOBLAST; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REGULATORY MECHANISM; SEX DIFFERENCE; SKELETON; TRABECULAR BONE;

EID: 3342962307     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-004-0119-8     Document Type: Article

References (55)

1. Rodan GA, Raisz LG, Bilezikian JP (2002) Pathophysiology of osteoporosis. In: Bilezikian JP, Raisz LG, Rodan GA (eds) Principles of bone biology. Academic Press, San Diego, pp 1275-1289
2. Compston JE (2001) Sex steroids and bone. Physiological Reviews 81:419-447
3. Swartz CM, Young MA (1988) Male hypogonadism and bone fracture. N Eng J Med 318:996
4. Bilezikian JP, Khosla S, Riggs BL (2002) Estrogen effects on bone in the male skeleton. In: Bilezikian JP, Raisz LG, Rodan GA (eds) Principles of bone biology. Academic Press, San Diego, pp 1467-1476
5. Vermeulen A (1990) Androgens and male senescence. In: Nieschlag E, Behre NM (eds) Testosterone:action, deficiency, substitution. Springer Verlag, Heidelberg, pp 261-276
6. Smith EP, Boyd J, Frank G, Takahashi H, Cohen RM, Specker B, Williams TC, Lubahn DB, Korach KS (1994) Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. New Engl J Med 331:1056-1061
7. Rochira V, Balestrieri A, Faustini-Fustini M, Carani C (2001) Role of estrogen on bone in the human male: insights from the natural models of congenital estrogen deficiency. Mol Cell Biol 178:215-220
8. Carani C, Qin K, Simoni M, Faustini-Fustini M, Serpente S, Boyd J, Korach KS, Simpson ER (1997) Effect of testosteone and estradiol in a man with aromatase deficiency. Engl J Med 337:91-95
9. Kousteni S, Chen JR, Bellido T, et al. (2002) Reversal of bone loss in mice by nongenotropic signaling of sex steroids. Science 298:723-724
10. Hock JM, Fitzpatrick LA, Bilezikian JP (2002) Actions of parathyroid hormone. In: Bilezikian JP, Raisz LG, Rodan GA (eds) Principles of bone biology. Academic Press, San Diego, pp 463-482
11. Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster JY, Hodsman AB, Eriksen EF, Ish-Shalom S, Genant H, Wang O, Mitlak BH (2001) Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Eng J Med 10:1434-1441
12. Ma YL, Cain RL, Halladay DL, Yang X, Zeng Q, Miles RR, Chandrasekhar S, Martin TJ, Onyia JE (2001) Catabolic effects of continuous human PTH (1-38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation. Endocrinology 142:4047-4054
13. Leder BZ, Smith MR, Fallon MA, Lee ML, Finkelstein JS (2001) Effects of gonadal steroid suppression on skeletal sensitivity to parathyroid hormone in men. J Clin Endocrinol Metab 86:511-516
14. Jüppner H, Abou-Samra AB, Freeman M, et al. (1991) A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254:1024-1026
15. Eriksen EF, Colvard DS, Berg NJ, Graham ML, Mann KG, Spelsberg TC, Riggs BL (1988) Evidence of estrogen receptors in normal human osteoblast-like cells. Science 241:84-86
16. Abu EO, Homer A, Kusec V, Triffitt JT, Compston JE (1997) The localization of androgen receptors in human bone. J Clin Endocrinol Metab 82:3493-3497
17. Kasperk CH, Wergedal JE, Parley JR, Linkhart TA, Turner RT, Baylink DJ (1989) Androgens directly stimulate proliferation of bone cells in vitro. Endocrinology 124:1576-1578
18. Fukayama S, Tashjian AH Jr (1989) Direct modulation by estradiol of the response of human bone cells (SaOS-2) to human parathyroid hormone (PTH) and PTH-related potein. Endocrinology 124:397-401
19. Fukayama S, Tashjian AH Jr (1989) Direct stimulation by androgens of the response of human bone cells (SaOS-2) to human parathyroid hormone (PTH) and PTH-related protein. Endocrinology 125:1789-1794
20. Ohno S (1971) Simplicity of mammalian regulatory systems inferred by single gene determination of sex phenotypes. Nature 234:134-137
21. Yarbrough WG, Quarmby VE, Simental JA, Joseph DR, Sar M, Lubahn DB, Olsen KL, French FS (1990) A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat. J Biol Chem 265:8893-8900
22. Vanderschueren D, Van Herck E, Suiker A, Visser W, Schot LP, Chung K, Lucas RS, Einhorn TA, Bouillon R (1993) Bone and mineral metabolism in the androgen-resistant (testicular feminized) male rat. J Bone Miner Res 8:801-809
23. McCauley LK, Tözüm TF, Rosol TJ (2002) Estrogen receptors in skeletal metabolism: lessons from genetically modified models of receptor function. Crit Revi Eukaryotic Gene Expression 12:89-100
24. Windahl SH, Andersson G, Gustafsson JÅ (2002) Elucidation of estrogen receptor function in bone with the use of mouse models. TEM 13:195-200
25. Dupont S, Krust A, Gansmuller A, Dierich A, Chambon P, Mark M (2000) Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development. 127:4277-4291
26. McCauley LK, Tözüm TF, Kozloff K, et al. (2003) Transgenic models of metabolic bone disease: impact of estrogen receptor deficiency on skeletal metabolism. Connect Tissue Res 4481:250-263
27. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR (1989) Bone histomorphometry: standardization of nomenclature, symbols, and units. J Bone Miner Res 2:595-610
28. McCauley LK, Koh AJ, Beecher CA, Cui Y, Rosol TJ, Franceschi RT (1996) PTH/PTHrP receptor is temporally regulated during osteoblast differentiation and is associated with collagen synthesis. J Cell Biochem 61:638-647
29. Chen H, McCauley LK, D'Silva N (2002) cAMP binding protein assay for widespread use in cell signaling studies. Biotechniques 33:66-72
30. Puchtler H, Meloan SN (1978) Demonstration of phosphates in calcium deposits: a modification of von kossa reaction. Histochemistry 56:177-185
31. Lindberg MK, Moverare S, Skrtic S, Alatalo S, Halleen J, Mohan S, Gustafsson J-A, Ohlsson C (2002) Two different pathways for the maintenance of trabecular bone in adult male mice. J Bone Miner Res 17:555-562
32. Okazaki R, Inoue D, Shibata M, Saika M, Kido S, Ooka H, Tomiyama H, Sakamoto Y, Matsumoto T (2002) Estrogen promotes early osteoblast differentiation and inhibits adipocyte differentiation in mouse bone marrow stromal cell lines that express estrogen receptor (ER) alpha or beta. Endocrinology 143:2349-2356
33. Pietras RJ, Szego CM (1999) Cell membrane estrogen receptors resurface. Nat Med 5:1330.
34. Aronica SM, Kraus WL, Katzenellenbogen BS (1994) Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription. Proc Natl Acad Sci USA 91:8517-8521
35. Turner RT, Riggs BL, Spelsberg TC (1994) Skeletal effects of estrogen. Endocrine Rev 15:275-300
36. Windahl SH, Vidal O, Andersson G, Gustafsson JA, Ohlsson C (1999) Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERβ-/-mice. J Clin Invest 104:895-901
37. Vanderschueren D, Van Herck E, Geusens P, Suiker A, Visser W, Chung K, Bouillon R (1994) Androgen resistance and deficiency have different effects on the growing skeleton of the rat. Calcif Tissue Int 55:198-203
38. Sims NA, Dupont S, Krust A, Clement-Lacroix P, Minet D, Resche-Rigon M, Gaillard-Kelly M, Baron R (2002) Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-β in bone remodeling in females but not in males. Bone 30:18-25
39. Vidal O, Lindberg MK, Sävendahl L, Lubahn DB, Ritzen EM, Gustafsson JÅ, Ohlsson C (1999) Disproportional body growth in female estrogen receptor-α inactivated mice. Biochem Biophys Res Commun 265:569-571
40. Vidal O, Lindberg MK, Hollberg K, Baylink DJ, Andersson G, Lubahn DB, Mohan S, Gustafsson JA, Ohlsson C (2000) Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice. Proc Natl Acad Sci USA 97:5474-5479
41. Vandenput L, Ederveen AGH, Erben R, Stahr K, Swinnen JV, Van Herck E, Verstuyf A, Boonen S, Bouillon R, Vanderschueren D (2001) Testosterone prevents orchidectomy-induced bone loss in estrogen receptor-α knockout mice. Biochem Biophys Res Commun 285:70-76
42. Öz OK, Hirasawa G, Lawson J, et al. (2001) Bone phenotype of the aromatase-deficient mouse. J Steroid Biochem Mol Biol 79:49-59
43. Turner RT (1999) Mice, estrogen, and postmenopausal osteoporosis. J Bone Miner Res 14:187-191
44. Zhang XZ, Kalu DN, Erbas B, Hopper JL, Seeman E (1999) The effects of gonadectomy on bone size, mass, and volumetric density in growing rats are gender-, site-, and growth hormone-specific. J Bone Miner Res 14:802-809
45. Wakley GK, Schutte HDJ, Hannon KS, Turner RT (1991) Androgen treatment prevents loss of cancellous bone in the orchidectomized rat. J Bone Miner Res 6:325-330
46. Vandenput L, Boonen S, Van Herck E, Swinnen JV, Bouillon R, Vanderschueren D (2002) Evidence from the aged orchidectomized male rat model that 17 beta-estradiol is a more effective bone-sparing and anabolic agent than 5 alpha-dihydrotestosterone. J Bone Miner Res 17:2080-2086
47. McDougall KE, Perry MJ, Gibson RL, Colley SM, Korach KS, Tobias JH (2003) Estrogen receptor-α dependency of estrogen's stimulatory action on cancellous bone formation in male mice. Endocrinology 144:1994-1999
48. Turner RT, Hannon KS, Demers LM, Buechler J, Bell NH (1989) Differential effects of gonadal function on bone histomorphometry in male and female rats. J Bone Miner Res 4:557-563
49. Qiu S, Rao DS, Palnitkar S, Parfitt AM (2002) Relationships between osteocyte density and bone formation rate in human cancellous bone. Bone 31:709-711
50. Collins P, Webb C (1999) Estrogen hits surface. Nat Med 5:1130-1131
51. Kousteni S, Han L, Chen JR, Almeida M, Plotkin LI, Bellido T, Manolagas SC (2003) Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids. J Clin Invest 111:1651-1664
52. Endoh H, Sasaki H, Maruyama K, Takeyama K, Waga I, Shimizu T, Kato S, Kawashima H (1997) Rapid activation of MAP kinase by estrogen in the bone cell line. Biochem Biophys Res Commun 235:99-102
53. Verhaar HJ, Damen CA, Duursma SA, Scheven BA (1994) A comparison of the action of progestins and estrogen on the growth and differentiation of normal adult human osteoblast-like cells in vitro. Bone 15:307-311
54. Partridge NC, Bloch SR, Pearman AT (1994) Signal transduction pathways mediating parathyroid hormone regulation of osteoblastic gene expression. J Cell Biochem 55:321-327
55. Kurland ES, Cosman F, McMahon DJ, Rosen CJ, Lindsay R, Bilezikian JP (2000) Parathyroid hormone as a therapy for idiopathic osteoporosis in men: effects on bone mineral density and bone markers. J Clin Endocrinol Metab 85:3069-3076