Cloning of two carotenoid ketolase genes from Nostoc punctiforme for the heterologous production of canthaxanthin and astaxanthin

Biotechnology Letters

Volumn 26, Issue 10, 2004, Pages 813-817

  Steiger, Sabine ^a   Sandmann, Gerhard ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

carotene ketolase; Astaxanthin; Canthaxanthin; Heterologous carotenoid production

Indexed keywords

ASTAXANTHIN; BACTERIAL PROTEIN; BETA CAROTENE; CANTHAXANTHIN; CAROTENOID; CRTW PROTEIN, BACTERIA; DRUG DERIVATIVE; OXYGENASE; RECOMBINANT PROTEIN; XANTHOPHYLL;

AMINO ACID SEQUENCE; ARTICLE; BIOSYNTHESIS; CHEMISTRY; ENZYMOLOGY; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; METHODOLOGY; MOLECULAR CLONING; MOLECULAR GENETICS; NOSTOC; PHYSIOLOGY; PROTEIN ENGINEERING;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BETA CAROTENE; CANTHAXANTHIN; CAROTENOIDS; CLONING, MOLECULAR; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MOLECULAR SEQUENCE DATA; NOSTOC; OXYGENASES; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; XANTHOPHYLLS;

ESCHERICHIA COLI; NOSTOC; NOSTOC PUNCTIFORME; NOSTOC PUNCTIFORME PCC 73102; NOSTOC SP.; PROKARYOTA;

EID: 3342944435     PISSN: 01415492     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:BILE.0000025880.91269.cf     Document Type: Article

References (14)

1. Albrecht M, Steiger S, Sandmann G (2001) Expression of a ketolase gene mediates the synthesis of canthaxanthin in Synechococcus leading to resistance against pigment photodegradation and UV-B sensitivity of photosynthesis. Photochem. Photobiol. 73: 551-555.
2. Borovkov AY, Rivkin MI (1997) pBBR1MCS: XcmI-containing vector for direct cloning of per products. BioTechniques 22: 812-814.
3. Breitenbach J, Misawa N, Kajiwara S, Sandmann G (1996) Expression in Escherichia coli and properties of the carotene ketolase from Haematococcus pluvialis. FEMS Microbiol. Lett. 140: 241-246.
4. Fernández-Gonzalez B, Sandmann G, Vioque A (1997) A new type of asymmetrically acting β-carotene ketolase is required for the synthesis of echinenone in the cyanobacterium Synechocystis sp. PCC 6803. J. Biol. Chem. 272: 9728-9733.
5. Fraser PD, Shimada H, Misawa N (1998) Enzymic confirmation of reactions involved in routes to astaxanthin formation, elucidated using a direct substrate in vitro assay. Eur. J. Biochem. 252: 229-236.
6. Goodwill TW (1980) The Biochemistiy of the Carotenoids, Vol. 1: Plants, 2nd edn. New York: Chapman & Hall.
7. Harker M, Hirschberg J (1999) Carotenoid biosynthesis genes in the bacterium Paracoccus marcusii MH1. Submission to data base: Accession No. Y15112.
8. Johnson EA, An GH (1991) Astaxanthin from microbial sources. Crit. Rev. Biotechnol. 11: 297-326.
9. Lorenz RT, Cysewski GR (2000) Commercial potential for Haematococcus microalgae as a natural source of astaxanthin. Trends Biotechnol. 18: 160-167.
10. Meyers SP (1994) Developments in world aquaculture, feed formulations and role of carotenoids. Pure Appl. Chem. 66: 1069-1076.
11. Misawa N, Satomi Y, Kondo K, Yokoyama A, Kajiwara S, Saito T, Ohtani T, Miki W (1995) Structure and functional analysis of a marine bacterial carotenoid biosynthesis gene cluster and astaxanthin biosynthetic pathway proposed at the gene level. J. Bacteriol. 177: 6575-6584.
12. Rippka R, Deruelles J, Waterbury JB, Herdman M, Stanier RY (1979) Generic assignments, strain histories and properties of pure cultures of cyanobacteria. J. Gen. Microbiol. 111: 1-61.
13. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
14. Verdoes J, Krubasik P, Sandmann G, van Ooyen M (1999) Isolation and functional characterization of a novel type of carotenoid biosynthetic gene from Xanthophyllomyces dendrorhous. Mol. Gen. Genet. 262: 453-461.