Expression in Escherichia coli and properties of the carotene ketolase from Haematococcus pluvialis

FEMS Microbiology Letters

Volumn 140, Issue 2-3, 1996, Pages 241-246

  Breitenbach, Jürgen ^a   Misawa, Norihiko ^b   Kajiwara, Susumu ^b   Sandmann, Gerhard ^a  

^a GOETHE UNIVERSITY   (Germany)

^b KIRIN BREWERY CO LTD   (Japan)

Author keywords

Adonixanthin; Astaxanthin; Canthaxanthin; Gene bkt; Haematococcus pluvialis; Carotene ketolase

Indexed keywords

ADONIXANTHIN; ASTAXANTHIN; BETA CAROTENE; CAROTENE KETOLASE; KETOLASE; UNCLASSIFIED DRUG; ZEAXANTHIN;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ESCHERICHIA COLI; GENE EXPRESSION; HAEMATOCOCCUS; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL;

EID: 0030199805     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-1097(96)00187-5     Document Type: Article

References (23)

1. [1] Miki, W. (1991) Biological functions and activities of animal carotenoids. Pure Appl. Chem. 63, 141-146.
2. [2] Hagen, C., Braune, W. and Greulich, F. (1993) Functional aspects of secondary carotenoids in Haematococcus lacustris [Girod] Rostafinsky (Volvocales). IV. Protection from photodynamic damage. J. Photochem. Photobiol. B: Biol. 20, 153-160.
3. [3] Krinsky, N.I. (1994) The biological properties of carotenoids. Pure Appl. Chem. 66, 1003-1010.
4. [4] Bernhard, K. (1989) Synthetic astaxanthin. The route of a carotenoid from research to commercialization. In: Carotenoids, Chemistry and Biology (Krinsky, N.I., Mathews-Roth, M.M. and Taylor, R.F., Eds.), pp. 337-364. Plenum Press, New York.
5. [5] Nelis, H.J. and De Leenheer, A.P. (1991) Microbial sources of carotenoid pigments used in food and feeds, J. Appl. Bacteriol. 70, 181-191.
6. [6] Johnson, E.A. and An, G.-H. (1991) Astaxanthin from microbial sources. Crit. Rev. Biotechnol. 11, 297-326.
7. [7] Britton, G. (1988) Biosynthesis of carotenoids. In: Plant Pigments (Goodwin, T.W., Ed.), pp. 133-182. Academic Press, New York.
8. [8] Misawa, N. Satomi, Y., Kondo, K., Yokoyama, A., Kajiwara, S., Saito, T., Ohtani, T. and Miki, W. (1995) Structure and functional analysis of a marine bacterial carotenoid biosynthesis gene cluster and astaxanthin biosynthetic pathway proposed at the gene level. J. Bacteriol. 177, 6575-6584.
9. [9] Misawa, N., Kajiwara, S., Kondo, K., Yokoyama, A., Satomi, Y., Saito, T., Miki, W. and Ohtani, T. (1995) Canthaxanthin biosynthesis by the conversion of methylene to keto groups in a hydrocarbon β-carotene by a single gene. Biochem. Biophys. Res. Commun. 209, 867-876.
10. [10] Lotan, T. and Hirschberg J. (1995) Cloning and expression in Escherichia coli of the gene encoding β-C-4-oxygenase, that converts β-carotene to the ketocarotenoid canthaxanthin in Haematococcus pluvialis. FEBS Lett. 364, 125-128.
11. [11] Kajiwara, S., Kakizono, T., Saito, T., Kondo, K., Ohtani, T., Nishio, N., Nagai, S. and Misawa, N. (1995) Isolation and functional identification of a novel cDNA for astaxanthin biosynthesis from Haematococcus pluvialis, and astaxanthin synthesis in Escherichia coli. Plant Mol. Biol. 29, 343-352.
12. [12] Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning, A Laboratory Manual, 2nd Edn., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
13. [13] Hanna, Z., Fregeau, C., Prefontaine, G. and Brousseau, R. (1984) Construction of a family of universal expression plasmid vectors. Gene 30, 247-250.
14. [14] Bramley, P.M, and Sandmann, G. (1985) In vitro and in vivo biosynthesis of xanthophylls by the cyanobacterium Aphanocapsa, Phytochemistry 24, 2919-2922.
15. [15] Eugster, C.H. (1995) Chemical derivatization: Microscale tests for the presence of common functional groups in carotenoids. In: Carotenoids, Vol. 1A: Isolation and Analysis (Britton, G., Liaaen-Jensen, S. and Pfander, H., Eds.), pp. 73-74. Birkhäuser Verlag, Basel.
16. [16] Yokoyama, A. and Miki, W. (1995) Composition and presumed biosynthetic pathway of carotenoids in the astaxanthin-producing bacterium Agrobacterium aurantiacum. FEMS Microbiol. Lett. 128, 139-144.
17. [17] Laemmli, U.K. (1970) Cleavage of structural proteins during assembley of the head of bacteriophage T4. Nature 227, 680-685.
18. [18] Petersen, G.L. (1977) A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal. Biochem. 83, 346-356.
19. [19] Griggs, D.L., Hedden, P. and Lazarus C.M. (1991) Partial purification of two gibberellin 2β-hydroxylases from cotyledons of Phaseolus vulgaris. Phytochemistry 30, 2507-2512.
20. [20] Sandmann, G. and Bramley, P. (1985) The in vitro biosynthesis of β-cryptoxanthin and related xanthophylls with Aphanocapsa membranes. Biochim. Biophys. Acta 843, 73-77.
21. [21] Gribanovski Sassu, O. (1972) Effect of diphenylamine on carotenoid synthesis in Dictyococcus cinnabarinus. Phytochemistry 11, 3195-3198.
22. [22] Fraser, P.D. and Sandmann, G. (1992) In vitro assays of three carotenogenic membrane-bound enzymes from Escheriachia coli transformed with different crt genes. Biochem. Biophys. Res. Commun. 185, 9-15.
23. [23] Fan, L., Vonshak, A., Gabbay, R., Hirschberg, J. and Boussiba, S. (1995) The biosynthetic pathway of astaxanthin in a green alga Haematococcus pluvialis as indicated by inhibition with diphenylamine. Plant Cell Physiol. 36, 1519-1524.