Dietary supplementation with the tribomechanically activated zeolite clinoptilolite in immunodeficiency: Effects on the immune system

Advances in Therapy

Volumn 21, Issue 2, 2004, Pages 135-147

  Ivkovic, Slavko ^a   Deutsch, Ulrich ^a   Silberbach, Angelika ^a   Walraph, Erwin ^b   Mannel, Marcus ^c  

^a Laboratory for Immunology ^*  (Germany)

^b Laboratory for Immunology   (Germany)

^c Ad libitum Medical Services   (Germany)

Author keywords

Antioxidants; Clinical trial; Clinoptilolite; Dietary supplements; Immunologic deficiency syndromes; Immunomodulators; Immunotherapies; Superantigens; TMAZ; Zeolites

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; CD19 ANTIGEN; CD4 ANTIGEN; CLINOPTILOLITE; HLA DR ANTIGEN; LYCOPENE; MAGNESIUM STEARATE; UNCLASSIFIED DRUG; ZEOLITE;

ADSORPTION; ADULT; AGED; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD CELL COUNT; CATION EXCHANGE; CHEMICAL COMPOSITION; CRYSTAL STRUCTURE; DIET SUPPLEMENTATION; FEMALE; HUMAN; IMMUNE DEFICIENCY; IMMUNOTHERAPY; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PHYSICAL CHEMISTRY; STATISTICAL ANALYSIS;

EID: 3342889498     PISSN: 0741238X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02850340     Document Type: Article

References (34)

1. Mumpton FA. La roca magica: uses of natural zeolites in agriculture and industry. Proc Natl Acad Sci USA. 1999;96:3463-3470.
2. Pavelic K, Hadzija M. Medical applications of zeolites. In: Auerbach SM, Carrado KA, Dutta PK (eds). Handbook of Zeolite Science and Technology. New York: Dekker; 2003; pp 1143-1174.
3. Cattaneo MV, Chang TM. The potential of a microencapsulated urease-zeolite oral sorbent for the removal of urea in uremia. ASAIO Trans. 1991;37:80-87.
4. Patzer JF II, Yao SJ, Wolfson SK Jr. Zeolitic ammonium ion exchange for portable hemodialysis dialysate regeneration. ASAIO J. 1995;41:221-226.
5. Seidel H, Bartko P, Kovác G, Paulíková I, Nagy O. Effects of haemoperfusion on selected Indices of blood biochemistry in sheep. Acta vet Brno. 1997;66:213-218.
6. Rodriguez-Fuentes G, Barrios MA, Iraizoz A, Perdomo I, Cedre B. Enterex-anti-diarrheic drug based on purified natural clinoptilolite. Zeolites. 1997;19:441-448.
7. Young SW, Qing F, Rubin D, et al. Gadolinium zeolite as an oral contrast agent for magnetic resonance imaging. J Magn Reson Imaging. 1995;5:499-508.
8. Keeting PE, Oursler MJ, Wiegand KE, Bonde SK, Spelsberg TC, Riggs BL. Zeolite A increases proliferation, differentiation, and transforming growth factor beta production in normal adult human osteoblast-like cells in vino. J Bone Miner Res. 1992;7:1281-1289.
9. Ivkovic S, Zabcic D. The effect of tribomechanically activated zeolite (TMAZ) on total antioxidant status of healthy individuals and patients with malignant disease. Free Radic Biol Med. 2002;33(suppl 1):172.
10. Ivkovic S, Zabcic D. Antioxidative Therapy: nanotechnology product TMA-Zeolite reduces oxidative stress in cancer and diabetic patients. Free Radic Biol Med. 2002;33(suppl 2):331.
11. Nikawa H, Yamamoto T, Hamada T, Rahardjo MB, Murata H, Nakanoda S. Antifungal effect of zeolite-incorporated tissue conditioner against Candida albicans growth and/or acid production. J Oral Rehabil. 1997;24:350-357.
12. Morishita M, Miyagi M, Yamasaki Y, Tsuruda K, Kawahara K, Iwamoto Y. Pilot study on the effect of a mouthrinse containing silver zeolite on plaque formation. J Clin Dent. 1998;9:94-96.
13. Uchida T, Maru N, Furuhata M, et al. [Anti-bacterial zeolite balloon catheter and its potential for urinary tract infection control.] Article in Japanese. Hinyokika Kiyo. 1992;38:973-978.
14. Oschilewski U, Kiesel U, Kolb H. Administration of silica prevents diabetes in BB-rats. Diabetes. 1985;34:197-199.
15. Charlton B, Bacelj A, Mandel TE. Administration of silica particles or anti-Lyt2 antibody prevents beta-cell destruction in NOD mice given cyclophosphamide. Diabetes. 1988;37:930-935.
16. Ueki A, Yamaguchi M, Ueki H, et al. Polyclonal human T-cell activation by silicate in vitro. Immunology. 1994;82:332-335.
17. Aikoh T, Tomokuni A, Matsukii T, et al. Activation-induced cell death in human peripheral blood lymphocytes after stimulation with silicate in vitro. Int J Oncol. 1998;12:1355-1359.
18. Muller-Alouf H, Carnoy C, Simonet M, Alouf JE. Superantigen bacterial toxins: state of the art. Toxicon. 2001;39:1691-1701.
19. Allison AC, Harington JS, Birbeck M. An examination of the cytotoxic effects of silica on macrophages. J Exp Med. 1966;124:141-154.
20. Drumm K, Oettinger R, Smolarski R, Bay M, Kienast K. In vitro study of human alveolar macrophages inflammatory mediator transcriptions and releases induced by soot FR 101, Printex 90, titandioxide and Chrysotile B. Eur J Med Res. 1998;3:432-438.
21. Pavelic K, Katic M, Sverko V, et al. Immunostimulatory effect of natural clinoptilolite as a possible mechanism of its antimetastatic ability. J Cancer Res Clin Oncol. 2002;128:37-44.
22. Martin-Kleiner I, Flegar-Mestric Z, Zadro R, et al. The effect of the zeolite clinoptilolite on serum chemistry and hematopoiesis in mice. Food Chem Toxicol. 2001;39:717-727.
23. Nezhinskaia GI, Sapronov NS. [Assessment of the rhythm of lymphocyte stimulation and suppression as a criterion of prognosis of the effects of immunomodulatory drugs.] Article in Russian. Patol Fiziol Eksp Ter. 2002;3:22-25.
24. Martin LD, Krunkosky TM, Dye JA, et al. The role of reactive oxygen and nitrogen species in the response of airway epithelium to particulates. Environ Health Perspect. 1997;105(suppl 5): 1301-1307.
25. Ginn-Pease ME, Whisler RL. Redox signals and NF-kappaB activation in T cells. Free Radic Biol Med. 1998;25:346-361.
26. Kaul N, Choi J, Forman HJ. Transmembrane redox signaling activates NF-kappaB in macrophages. Free Radic Biol Med. 1998;24:202-207.
27. Tsuda T, Morimoto Y, Yamato H, et al. Effects of mineral fibers on the expression of genes whose product may play a role in fiber pathogenesis. Environ Health Perspect. 1997;105(suppl 5): 1173-1178.
28. Lim Y, Kim SH, Kim KA, Oh MW, Lee KH. Involvement of protein kinase C, phospholipase C, and protein tyrosine kinase pathways in oxygen radical generation by asbestos-stimulated alveolar macrophage. Environ Health Perspect. 1997;105(suppl 5):1325-1327.
29. Simeonova PP, Toriumi W, Kommineni C, et al. Molecular regulation of IL-6 activation by asbestos in lung epithelial cells: role of reactive oxygen species. J Immunol. 1997;159:3921-3928.
30. Totterman TH, Gidlof C, Ragnarsson L, et al. Targeted superantigens for immunotherapy of haematopoietic tumours. Vox Sang. 1998;74(suppl 2):483-487.
31. Macphail S. Superantigens: mechanisms by which they may induce, exacerbate and control autoimmune diseases. Int Rev Immunol. 1999;18:141-180.
32. Stevens DL. Superantigens: their role in infectious diseases. Immunol Invest. 1997;26:275-281.
33. Zarkovic N, Zarkovic K, Kralj M, et al. Anticancer and antioxidative effects of micronized zeolite clinoptilolite. Anticancer Res. 2003;23:1589-1595.
34. Pavelic K, Katic M, Sverko V, et al. Immunostimulatory effect of natural clinoptilolite as a possible mechanism of its antimetastatic ability. J Cancer Res Clin Oncol. 2002;128:37-44.