The formation of an intrachain disulfide bond in the leptin protein is necessary for efficient leptin secretion

Biochimie

Volumn 86, Issue 6, 2004, Pages 351-356

  Boute, N ^a   Zilberfarb, V ^a   Camoin, L ^a   Bonnafous, S ^a   Le Marchand Brustel, Y ^a   Issad, T ^a  

^a INSERM   (France)

Author keywords

Adipocyte; Leptin; Obesity; Secretion

Indexed keywords

COMPLEMENTARY DNA; CYSTEINE; DISULFIDE; LEPTIN; MUTANT PROTEIN; SERINE;

ACID SECRETION; ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL STRAIN COS1; CONTROLLED STUDY; DISULFIDE BOND; FILTRATION; GENETIC CODE; MALE; MOLECULE; MUTAGENESIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SECRETION;

ADIPOCYTES; AMINO ACID SUBSTITUTION; ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; DISULFIDES; HUMANS; LEPTIN; MALE; POINT MUTATION; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 3342887701     PISSN: 03009084     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biochi.2004.06.005     Document Type: Article

References (23)

1. Zhang Y., Proenca M., Maffei M., Barone L., Leopold L. and Friedman J.M. Positional cloning of the mouse gene and its human homologue Nature (London) 372 1994 425 432
2. Montague C.T., Farooqi I.S., Whitehead J.P., Soos M.A., Rau H., Wareham N.J., Sewter C.P., Digby J.E., Mohammed S.N., Hurst J.A., Cheetham C.H., Earley A.R., Barnett A.H., Prins J.B. and O'Rahilly S. Congenital leptin deficiency is associated with severe early-onset obesity in humans Nature 387 1997 903 908
3. Strobel A., Issad T., Camoin L., Ozata M. and Strosberg A.D. A leptin missense mutation associated with hypogonadism and morbid obesity Nat. Genet. 18 1998 213 215
4. Rau H., Reaves B.J., O'Rahilly S. and Whitehead J.P. Truncated human leptin (delta133) associated with extreme obesity undergoes proteasomal degradation after defective intracellular transport Endocrinology 140 1999 1718 1723
5. Muller G., Ertl J., Gerl M. and Preibisch G. Leptin impairs metabolic actions of insulin in isolated rat adipocytes J. Biol. Chem. 272 1997 10585 10593
6. Rock F.L., Altmann S.W., van Heek M., Kastelein R.A. and Bazan J.F. The leptin haemopoietic cytokine fold is stabilized by an intrachain disulfide bond Horm. Metab. Res. 28 1996 649 652
7. Giese K., Fantl W.J., Vitt C., Stephans J.C., Cousens L., Wachowicz M. and Williams L.T. Reduction of food intake and weight gain by the ob protein requires a specific secondary structure and is reversible Mol. Med 2 1996 50 58
8. Imagawa K., Numata Y., Katsuura G., Sakaguchi I., Morita A., Kikuoka S., Matumoto Y., Tsuji T., Tamaki M., Sasakura K., Teraoka H., Hosoda K., Ogawa Y. and Nakao K. Structure - function studies of human leptin J. Biol. Chem. 273 1998 35245 35249
9. Grosfeld A., Zilberfarb V., Turban S., Andre J., Guerre-Millo M. and Issad T. Hypoxia increases leptin expression in human PAZ6 adipose cells Diabetologia 45 2002 527 530
10. Cormont M., Bortoluzzi M.N., Gautier N., Mari M., van Obberghen E. and Le Marchand-Brustel Y. Potential role of Rab4 in the regulation of subcellular localization of Glut4 in adipocytes Mol. Cell Biol. 16 1996 6879 6886
11. Bado A., Levasseur S., Attoub S., Kermorgant S., Laigneau J.P., Bortoluzzi M.N., Moizo L., Lehy T., Guerre-Millo M., Le Marchand-Brustel Y. and Lewin M.J. The stomach is a source of leptin Nature 394 1998 790 793
12. Zilberfarb V., Pietri-Rouxel F., Jockers R., Krief S., Delouis C., Issad T. and Strosberg A.D. Human immortalized brown adipocytes express functional beta3-adrenoceptor coupled to lipolysis J. Cell Sci. 110 Pt 7 1997 801 807
13. Zilberfarb V., Siquier K., Strosberg A.D. and Issad T. Effect of dexamethasone on adipocyte differentiation markers and tumour necrosis factor-alpha expression in human PAZ6 cells Diabetologia 44 2001 377 386
14. Pind S., Riordan J.R. and Williams D.B. Participation of the endoplasmic reticulum chaperone calnexin (p88, IP90) in the biogenesis of the cystic fibrosis transmembrane conductance regulator J. Biol. Chem. 269 1994 12784 12788
15. Illing M.E., Rajan R.S., Bence N.F. and Kopito R.R. A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome system J. Biol. Chem. 277 2002 34150 34160
16. Beuret N., Rutishauser J., Bider M.D. and Spiess M. Mechanism of endoplasmic reticulum retention of mutant vasopressin precursor caused by a signal peptide truncation associated with diabetes insipidus J. Biol. Chem. 274 1999 18965 18972
17. Booth D.R., Sunde M., Bellotti V., Robinson C.V., Hutchinson W.L., Fraser P.E., Hawkins P.N., Dobson C.M., Radford S.E., Blake C.C. and Pepys M.B. Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis Nature 385 1997 787 793
18. Khare S.D., Ding F. and Dokholyan N.V. Folding of Cu, Zn superoxide dismutase and familial amyotrophic lateral sclerosis J. Mol. Biol. 334 2003 515 525
19. Cresswell P. and Hughes E.A. Protein degradation: the ins and outs of the matter Curr. Biol 7 1997 R552 R555
20. Zhang F., Basinski M.B., Beals J.M., Briggs S.L., Churgay L.M., Clawson D.K., DiMarchi R.D., Furman T.C., Hale J.E., Hsiung H.M., Schoner B.E., Smith D.P., Zhang X.Y., Wery J.P. and Schevitz R.W. Crystal structure of the obese protein leptin-E100 Nature 387 1997 206 209
21. Wittrup K.D. Disulfide bond formation and eukaryotic secretory productivity Curr. Opin. Biotechnol. 6 1995 203 208
22. Sawyer J.T., Lukaczyk T. and Yilla M. Dithiothreitol treatment induces heterotypic aggregation of newly synthesized secretory proteins in HepG2 cells J. Biol. Chem. 269 1994 22440 22445
23. Yilla M., Doyle D. and Sawyer J.T. Early disulfide bond formation prevents heterotypic aggregation of membrane proteins in a cell-free translation system J. Cell Biol. 118 1992 245 252