Effects of the Paratemnus elongatus pseudoscorpion venom in the uptake and binding of the L-glutamate and GABA from rat cerebral cortex

Journal of Biochemical and Molecular Toxicology

Volumn 20, Issue 1, 2006, Pages 27-34

  Ferreira Dos Santos, Wagner ^a   Coutinho Netto, Joaquim ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

GABA; L glutamate; Neurotoxins; Paratemnus elongates; Pseudoscorpion venom

Indexed keywords

4 AMINOBUTYRIC ACID; GLUTAMATE RECEPTOR; GLUTAMIC ACID; NEUROTRANSMITTER; PSEUDOSCORPION VENOM; SPIDER VENOM; UNCLASSIFIED DRUG; VENOM; WASP VENOM;

ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARACHNID; ARTICLE; BRAIN CORTEX; GABAERGIC TRANSMISSION; MALE; NERVE INJURY; NEUROLOGIC DISEASE; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; PARATEMNUS ELONGATUS; PSEUDOSCORPION; RAT; SYNAPTOSOME;

ANIMALS; BIOLOGICAL TRANSPORT; CEREBRAL CORTEX; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; MALE; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SPIDER VENOMS; SYNAPTOSOMES;

ANIMALIA; ARACHNIDA; ARANEAE; MAMMALIA; VERTEBRATA;

EID: 33344479240     PISSN: 10956670     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbt.20113     Document Type: Article

References (44)

1. Watkins JC, Krogsgaard-Larsen P, Honoré T. Structure activity relationship in the development of excitatory amino acid receptor agonists and competitive antagonists. TIPS 1990;11:25-33.
2. Conley EC. The Ion Channel-Facts Book-Extracellular Ligand-Gated Channels, I. New York: Academic Press; 1996. p 426.
3. Hinoi E, Takarada T, Tsuchihashi Y, Yoneda Y. Glutamate transporters as drug targets. Curr Drug Targets CNS Neurol Disord 2005;4(2):211-220.
4. Edwards FA, Gibb AJ, Colquhoun D. ATP receptor-mediated synaptic currents in the central nervous system. Nature 1992;10(6391):144-147.
5. Manabe T, Renner P, Nicoll RA. Postsynaptic contribution to long-term potentiation revealed by analysis of miniature synaptic currents. Nature 1992;355(6355):50-54.
6. Collingridge GL, Watkins, JC. The NMDA Receptor, second edition. New York: Oxford University Press, 1994. p 503.
7. Rothman SM, Olney JW. Glutamate and the pathophysiology of hypoxic/ischemic brain damage. Ann Neurol 1987;19:105-111.
8. Louzada Dias JJ Jr, Santos WF, Lachat JJ, Bradford HF, Coutinho-Netto J. Release in experimental ischaemia of the retina na approach using microdialysis. J Neurochem 1992;59:358-363.
9. Sangstad JA, Kinzie JM, Shinohara MM, Segerson TP, Westbrook, GL. Cloning and expression of rat metabotropic glutamate receptor 8 revels a dsitinct pharmacological profile. Mol Pharmacol 1997;51(1):119-125.
10. Darlison MG. Invertebrate GABA and glutamate receptors: molecular biology revels predictable but some unusual pharmacologies. TINS 1992;15(12):469-474.
11. Hollmann M, Heinemann S. Cloned glutamate receptors. Ann Rev Neurosci 1994;17:31-108.
12. Ozawa S, Kamiya H, Tsuzuki K. Glutamate receptors in the mammalian central nervous system. Prog Neurobiol 1998;54:581-618.
13. Danbolt NC. Glutamate uptake. Prog Neurobiol 2001;65(1):1-105.
14. Beleboni RO, Carolino RO, Pizzo AB, Castellan-Baldan L, Coutinho-Netto J, Santos WF, Coimbra NC. Pharmacological and biochemical aspects of Gabaergic neurotransmission: Pathological and neuropsybiological relationships. Cell Mol Neurobiol 2004;24:707-728.
15. Coutinho-Netto J, Abdul-Ghani AS, Collins JF, Bradford, HF. The glutamate a trigger factor in epileptic hyperactivity? Epilepsia 1981;22:289-294.
16. Croucher MJ, Collin JF, Meldrum BS. Anticonvulsant action of excitatory amino acid antagonists. Science 1982;216:899-901.
17. Meldrum BS, Garthwaite J. Excitatory amino acid neurotoxicity and neurodegenerative disease. TIPS 1990;11:379-387.
18. Chen J, Lee, CT, Errico S, Deng X, Cadet JL, Freed WJ. Protective effects of delta(9)-tetrahydrocannabinol against N-methyl-d-aspartate-induced AF5 cell death. Brain Res Mol Brain Res 2005;134(2):215-225.
19. Erdo F, Berzsenyi P, Andrasi F. The AMPA-antagonist talampanel is neuroprotective in rodent models of focal cerebral ischemia. Brain Res Bull 2005;66(1):43-49.
20. Usherwood PNR. Insect glutamatergic receptors. Adv Insect Physiol 1994;24:309-341.
21. Green AC, Nakanishi K, Usherwood PNR. Polyamine amides are neuroprotective in cerebellar granule cell cultures challenged with excitatory amino acids. Brain Res 1996;717:136-146.
22. Corzo G, Escoubas P. Pharmacologically active spider peptide toxins. Cell Mol Life Sci 200;60(11):2409-2426.
23. Beleboni RO, Pizzo AB, Fontana ACK, Carolino OGC, Coutinho-Netto J, Santos WF. Spider and wasp neurotoxins: Pharmacological and biochemical aspects Eur J Pharmacol 2004;493(1-3):1-17.
24. Mellor IR, Usherwood PNR. Targeting ionotropic receptors with polyamine-containing toxins. Toxicon 2004;43(5):493-508.
25. Cairrão MAR, Ribeiro AM, Pizzo AB, Fontana ACK, Beleboni RO, Coutinho-Netto J, Miranda A, Santos WF. Anticonvulsant and GABA uptake inhibition properties of venom fractions from the spiders Parawixia bistriata and Scaptocosa raptoria. Phamac Biol 2002;40(6):472-477.
26. Fontana ACK, Guizzo R, Beleboni RO, Silva ARM, Coimbra NC, Amara SG, Santos WF, Coutinho-Netto J. Parawixia bistriata spider venom: Purification and characterization of a L-glutamate uptake stimulating compound with neuroprotective action. Brit J Pharmacol 2003;139(7):1297-1309.
27. Mussi-Ribeiro A, Miranda A, Gobbo-Netto L, Peporine Lopes N, Santos WF. A anticonvulsive fraction from Scaptocosa raptoria (Araneae: Lycosidae) spider venom. Neurosci Lett 2004;371(2-3):171-175.
28. Weygoldt P. The Biology of Pseudoscorpions. Cambridge, MA: Harvard University Press; 1969. p. 145.
29. Fantinatti A.P, Santos WF. Estudos preliminares sobre a adaptação do pseudoescorpião Paratemnus elongatus. Ciência Cultura 1987;39(1);abstract.
30. Coutinho-Netto, J. Livre-Docente thesis, Ribeirão Preto School of Medicine, University of São Paulo; 1980: p. 98.
31. Pizzo AB, Fontana AC, Coutinho-Netto J, Santos WF. Effects of the crude venom of the social wasp Agelaia vicina on gamma-aminobutyric acid and glutamate uptake in synaptosomes from rat cerebral cortex. J Biochem Mol Toxicol 2000;14(2):88-94.
32. Pizzo AB, Beleboni RO, Fontana ACK, Ribeiro AM, Miranda A, Coutinho-Netto J, Santos WF. Characterization of the actions of AvTx 7 isolated from Agelaia vicina (Hymenoptera: Vespidae) wasp venom on synaptosomal glutamate uptake and release. J Biochem Mol Toxicol 2004;18(2):61-68.
33. Gray EG, Whittaker VP. The isolation of nerve endings from brain: An aletron-microscopic study of cell fragments derived by homogenization and centrifugation. J Anat (London) 1962;96:79.
34. Hartree EF. Determination of protein: A modification of the Lowry method gives a linear photometric response. Anal Biochem 1972;48:422-477.
35. 3H]-L-glutamate binding sites in the rat hippocampal membranes. J Neurochem 1981;36:811-820.
36. Zukin SR, Young AB, Snyder SH. Gamma aminobutyric acid binding to receptor sites in the cat central nervous system. Proc Natl Acad Sci USA 1974;71:4802-4807.
37. Carolino RO, Beleboni RO, Pizzo AB, Vecchio FD, Garcia-Cairasco N, Moyses-Neto M, Santos WF, Coutinho-Netto J. Convulsant activity and neurochemical alterations induced by a fraction obtained from fruit Avenhoa carambola (Oxalidaceae: Geraniales). Neurochem Int 2005; 46(7):523-531.
38. Michaelis EK, Galton N, Early SL. Spider venoms inhibit L-glutamate binding to brain synaptic membrane receptors. Proc Natl Acad Sci (USA) 1984;81:5571-5574.
39. Roberts PJ, Watkins JC. Structural requirements for the inhibition for L-glutamate uptake by glia and nerve endings. Brain Res 1975;85:120-125.
40. Cunha AO, Mortari MR, Oliveira L, Carolino RO, Coutinho-Netto J, Ferreira Dos Santos W. Anticonvulsant effects of the wasp Polybia ignobilis venom on chemically induced seizures and action on GABA and glutamate receptors. Comp Biochem Physiol C Toxicol Pharmacol 2005;141(1):50-57.
41. Cunha AOS, Oliveira L, Vieira EB, Gelfuso EA, Mortari, MR, Santos WF. Anconvulsant and behavioral effects of the denatured venom of the social wasp Polybia occidentalis (Polistinae; Vespidae). Basic Clin Pharmacol Toxicol (in press).
42. Caccamo D, Campisi A, Curro M, Bramanti V, Tringali M, Volti GL, Vanella A, Ientile R. Antioxidant Treatment inhibited glutamate-evoked NF-kappaB activation in primary astroglial cell cultures. Neurotoxicology 2005;12:
43. Miljanich GP. Venom peptides as human pharmaceutical. Sci Med 1997; Sept/Oct: 06-15.
44. Uchitel OD. Toxins affecting calcium channels in neurons. Toxicon 1997;35(8):1161-1191.