Purification of a neuroprotective component of Parawixia bistriata spider venom that enhances glutamate uptake

British Journal of Pharmacology

Volumn 139, Issue 7, 2003, Pages 1297-1309

  Fontana, Andréia Cristina Karklin ^a,b   Guizzo, Renato ^a   De Oliveira Beleboni, Renê ^a   Meirelles E Silva, Antonio Renato ^a   Coimbra, Norberto Cysne ^a   Amara, Susan G ^b   Dos Santos, Wagner Ferreira ^a   Coutinho Netto, Joaquim ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Acute glaucoma; GABA uptake; Glutamate uptake; Neuroprotection; Neurotransmitter transport; Purification; Spider venom; Synaptosomes

Indexed keywords

4 AMINOBUTYRIC ACID; CALCIUM CHANNEL; GLUTAMIC ACID; PARAWIXIA BISTRIATA TOXIN 1.2.3; POTASSIUM CHANNEL; SODIUM CHANNEL; SPIDER VENOM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG ISOLATION; DRUG PURIFICATION; GLAUCOMA; ION EXCHANGE CHROMATOGRAPHY; MALE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPROTECTION; NEUROTRANSMITTER UPTAKE; NONHUMAN; PARAWIXIA BISTRIATA; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; RETINA GANGLION CELL; RETINA ISCHEMIA; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SPIDER; SYNAPTOSOME;

ANIMALS; BRAZIL; CARBON ISOTOPES; CEREBRAL CORTEX; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMMA-AMINOBUTYRIC ACID; GLAUCOMA; GLUTAMIC ACID; ION CHANNELS; MALE; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; RETINA; SPIDER VENOMS; SPIDERS; SYNAPTOSOMES; TISSUE EXTRACTS; TRITIUM;

EID: 0042387833     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705352     Document Type: Article

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