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Volumn 47, Issue 13, 2006, Pages 2237-2240

Development of synthetic routes to macrocyclic compounds based on the HSP90 inhibitor radicicol

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN 90 INHIBITOR; LACTAM DERIVATIVE; LACTONE DERIVATIVE; MACROCYCLIC COMPOUND; RADICICOL;

EID: 33344475514     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.01.116     Document Type: Article
Times cited : (14)

References (22)
  • 7
    • 3142717486 scopus 로고    scopus 로고
    • Several synthetic analogues of radicicol have been reported including cycloproparadicicol: X. Geng, Z.Q. Yang, and S.J. Danishefsky Synlett 2004 1325 1333 and references cited therein
    • (2004) Synlett , pp. 1325-1333
    • Geng, X.1    Yang, Z.Q.2    Danishefsky, S.J.3
  • 10
    • 33344479028 scopus 로고    scopus 로고
    • note
    • Greatly reduced yields were observed when the solvent was not degassed.
  • 11
    • 33344456779 scopus 로고    scopus 로고
    • note
    • The corresponding mesylate was found to be unstable.
  • 13
    • 33847804686 scopus 로고
    • No cyclisation was observed with dipyridyldisulfide/triphosphine in acetonitrile or xylene at reflux. E.J. Corey, and K.C. Nicolaou J. Am. Chem. Soc. 96 1974 5614 5616
    • (1974) J. Am. Chem. Soc. , vol.96 , pp. 5614-5616
    • Corey, E.J.1    Nicolaou, K.C.2
  • 15
    • 33344459924 scopus 로고    scopus 로고
    • note
    • 1-tetramethyluronium hexafluorophosphate (HATU) gave no evidence of cyclisation.
  • 16
    • 33344469039 scopus 로고    scopus 로고
    • note
    • 1-Ethyl-3-(3-dimethylaminopropyl)-carbodiimide.
  • 17
    • 33344476672 scopus 로고    scopus 로고
    • note
    • 1-3-Dipolar cycloaddition reactions, Lindlar hydrogenation, hydroboration and hydration of the alkyne bond were attempted without success.
  • 20
    • 33344468751 scopus 로고    scopus 로고
    • note
    • 3 resulted in unidentifiable product mixtures.
  • 22
    • 33344471390 scopus 로고    scopus 로고
    • doi:10.1016/j.tetlet.2006.01.099
    • These prototype compounds did not inhibit HSP90, but related compounds incorporating phenolic functionality have been shown to inhibit HSP90 ATPase. See following paper: Tetrahedron Lett. 2006, 47, doi:10.1016/j.tetlet.2006.01. 099.
    • (2006) Tetrahedron Lett. , vol.47


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.