-
2
-
-
0032959590
-
-
S.M. Roe, C. Prodromou, R. O'Brien, J.E. Ladbury, P.W. Piper, and L.H. Pearl J. Med. Chem. 42 1999 260 266
-
(1999)
J. Med. Chem.
, vol.42
, pp. 260-266
-
-
Roe, S.M.1
Prodromou, C.2
O'Brien, R.3
Ladbury, J.E.4
Piper, P.W.5
Pearl, L.H.6
-
4
-
-
23044441106
-
-
U. Banerji, A. O'Donnell, M. Scurr, S. Pacey, S. Stapleton, Y. Asad, L. Simmons, A. Maloney, F. Raynaud, M. Campbell, M. Walton, S. Lakhani, S. Kaye, P. Workman, and I. Judson J. Clin. Oncol. 23 2005 4152 4161
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 4152-4161
-
-
Banerji, U.1
O'Donnell, A.2
Scurr, M.3
Pacey, S.4
Stapleton, S.5
Asad, Y.6
Simmons, L.7
Maloney, A.8
Raynaud, F.9
Campbell, M.10
Walton, M.11
Lakhani, S.12
Kaye, S.13
Workman, P.14
Judson, I.15
-
5
-
-
20644448390
-
-
K.-M. Cheung, T. Matthews, K. James, M. Rowlands, K. Boxall, S. Sharp, A. Maloney, S.M. Roe, C. Prodromou, L. Pearl, G.W. Aherne, E. McDonald, and P. Workman Bioorg. Med. Chem. Lett. 15 2005 3338 3343
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 3338-3343
-
-
Cheung, K.-M.1
Matthews, T.2
James, K.3
Rowlands, M.4
Boxall, K.5
Sharp, S.6
Maloney, A.7
Roe, S.M.8
Prodromou, C.9
Pearl, L.10
Aherne, G.W.11
McDonald, E.12
Workman, P.13
-
6
-
-
21244505104
-
-
B. Dymock, X. Barril, P. Brough, J. Cansfield, A. Massey, E. McDonald, R. Hubbard, A. Surgenor, S. Roughley, P. Webb, P. Workman, L. Wright, and M. Drysdale J. Med. Chem. 48 2005 4212 4215
-
(2005)
J. Med. Chem.
, vol.48
, pp. 4212-4215
-
-
Dymock, B.1
Barril, X.2
Brough, P.3
Cansfield, J.4
Massey, A.5
McDonald, E.6
Hubbard, R.7
Surgenor, A.8
Roughley, S.9
Webb, P.10
Workman, P.11
Wright, L.12
Drysdale, M.13
-
7
-
-
3142717486
-
-
Several synthetic analogues of radicicol have been reported including cycloproparadicicol: X. Geng, Z.Q. Yang, and S.J. Danishefsky Synlett 2004 1325 1333 and references cited therein
-
(2004)
Synlett
, pp. 1325-1333
-
-
Geng, X.1
Yang, Z.Q.2
Danishefsky, S.J.3
-
8
-
-
18744411808
-
-
and pochonin D E. Moulin, V. Zoete, S. Barluenga, M. Karplus, and N. Winssinger J. Am. Chem. Soc. 127 2005 6999 7004
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 6999-7004
-
-
Moulin, E.1
Zoete, V.2
Barluenga, S.3
Karplus, M.4
Winssinger, N.5
-
10
-
-
33344479028
-
-
note
-
Greatly reduced yields were observed when the solvent was not degassed.
-
-
-
-
11
-
-
33344456779
-
-
note
-
The corresponding mesylate was found to be unstable.
-
-
-
-
12
-
-
0001616071
-
-
J. Inaga, K. Hirata, H. Sacki, T. Katsuki, and M. Yamaguchi Bull. Chem. Soc. Jpn. 52 1979 1989
-
(1979)
Bull. Chem. Soc. Jpn.
, vol.52
, pp. 1989
-
-
Inaga, J.1
Hirata, K.2
Sacki, H.3
Katsuki, T.4
Yamaguchi, M.5
-
13
-
-
33847804686
-
-
No cyclisation was observed with dipyridyldisulfide/triphosphine in acetonitrile or xylene at reflux. E.J. Corey, and K.C. Nicolaou J. Am. Chem. Soc. 96 1974 5614 5616
-
(1974)
J. Am. Chem. Soc.
, vol.96
, pp. 5614-5616
-
-
Corey, E.J.1
Nicolaou, K.C.2
-
15
-
-
33344459924
-
-
note
-
1-tetramethyluronium hexafluorophosphate (HATU) gave no evidence of cyclisation.
-
-
-
-
16
-
-
33344469039
-
-
note
-
1-Ethyl-3-(3-dimethylaminopropyl)-carbodiimide.
-
-
-
-
17
-
-
33344476672
-
-
note
-
1-3-Dipolar cycloaddition reactions, Lindlar hydrogenation, hydroboration and hydration of the alkyne bond were attempted without success.
-
-
-
-
19
-
-
37049080959
-
-
O. Moriya, H. Takenaka, M. Lyoda, Y. Urata, and T. Endo J. Chem. Soc., Perkin Trans. 1 1994 413 418
-
(1994)
J. Chem. Soc., Perkin Trans. 1
, pp. 413-418
-
-
Moriya, O.1
Takenaka, H.2
Lyoda, M.3
Urata, Y.4
Endo, T.5
-
20
-
-
33344468751
-
-
note
-
3 resulted in unidentifiable product mixtures.
-
-
-
-
22
-
-
33344471390
-
-
doi:10.1016/j.tetlet.2006.01.099
-
These prototype compounds did not inhibit HSP90, but related compounds incorporating phenolic functionality have been shown to inhibit HSP90 ATPase. See following paper: Tetrahedron Lett. 2006, 47, doi:10.1016/j.tetlet.2006.01. 099.
-
(2006)
Tetrahedron Lett.
, vol.47
-
-
|