메뉴 건너뛰기




Volumn 7, Issue 3, 2003, Pages 380-387

Microfluidic combinatorial chemistry

Author keywords

[No Author keywords available]

Indexed keywords

ESTER DERIVATIVE; KETONE DERIVATIVE; REAGENT;

EID: 0038198834     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(03)00050-4     Document Type: Review
Times cited : (95)

References (43)
  • 1
    • 0009504993 scopus 로고    scopus 로고
    • Chemical reduction
    • Bradley D. Chemical reduction. Eur. Chem. 1:1999;17-20.
    • (1999) Eur. Chem. , vol.1 , pp. 17-20
    • Bradley, D.1
  • 3
    • 0006029565 scopus 로고    scopus 로고
    • Chip service
    • Cowen S: Chip service. Chem Ind 1999:584-586.
    • (1999) Chem Ind , pp. 584-586
    • Cowen, S.1
  • 4
    • 0006068822 scopus 로고    scopus 로고
    • Reducing the risks of synthesis
    • McCreedy T: Reducing the risks of synthesis. Chem Ind 1999:588-590.
    • (1999) Chem Ind , pp. 588-590
    • McCreedy, T.1
  • 6
  • 11
    • 0034213763 scopus 로고    scopus 로고
    • Fabrication techniques and materials commonly used for the production of micro reactors and micro total analytical systems
    • McCreedy T. Fabrication techniques and materials commonly used for the production of micro reactors and micro total analytical systems. TrAC. 19:2000;396-401.
    • (2000) TrAC , vol.19 , pp. 396-401
    • McCreedy, T.1
  • 12
    • 0035910644 scopus 로고    scopus 로고
    • Rapid prototyping of glass and PDMS microstructures for micro total analytical systems and micro chemical reactors by microfabrication in the general laboratory
    • McCreedy T. Rapid prototyping of glass and PDMS microstructures for micro total analytical systems and micro chemical reactors by microfabrication in the general laboratory. Anal. Chim. Acta. 427:2001;39-43.
    • (2001) Anal. Chim. Acta. , vol.427 , pp. 39-43
    • McCreedy, T.1
  • 13
    • 0000984751 scopus 로고
    • Electrokinetic phenomena
    • Edited by Kruyt HR. Amsterdam: Elsevier
    • Overbeek J: Electrokinetic phenomena. In Colloid Science. Edited by Kruyt HR. Amsterdam: Elsevier; 1952:195-244.
    • (1952) Colloid Science , pp. 195-244
    • Overbeek, J.1
  • 14
    • 33947485034 scopus 로고
    • Electrokinetic flow in a narrow cylindrical capillary
    • Rice C.L., Whitehead R. Electrokinetic flow in a narrow cylindrical capillary. J. Phys. Chem. 69:1965;4017-4024.
    • (1965) J. Phys. Chem. , vol.69 , pp. 4017-4024
    • Rice, C.L.1    Whitehead, R.2
  • 16
    • 0002581914 scopus 로고
    • The electrokinetic potential of glasses in aqueous electrolyte solutions
    • Jednacak J., Pravdic V., Haller W. The electrokinetic potential of glasses in aqueous electrolyte solutions. J. Colloid Interface Sci. 49:1974;16-23.
    • (1974) J. Colloid Interface Sci. , vol.49 , pp. 16-23
    • Jednacak, J.1    Pravdic, V.2    Haller, W.3
  • 17
    • 0141886236 scopus 로고    scopus 로고
    • Electrokinetic control of a chemical reaction in a lab-on-a-chip micro reactor: Measurement and quantitative modelling
    • 2+ ions have a greater electrophoretic velocity than the neutral ligand.
    • 2+ ions have a greater electrophoretic velocity than the neutral ligand.
    • (2002) Lab on a Chip , vol.2 , pp. 101-112
    • Fletcher, P.D.I.1    Haswell, S.J.2    Zhang, X.3
  • 18
    • 0037054163 scopus 로고    scopus 로고
    • Micro reactors: Principles and applications in organic synthesis
    • This review article gives a detailed account of the fabrication and operation of microreactors. The paper gives a detailed account of all gas phase, liquid phase and catalysed reactions performed in microreactors to date.
    • Fletcher P.D.I., Haswell S.J., Pombo-Villar E., Warrington B.H., Watts P., Wong S.Y.F., Zhang X. Micro reactors: principles and applications in organic synthesis. Tetrahedron. 58:2002;4735-4757 This review article gives a detailed account of the fabrication and operation of microreactors. The paper gives a detailed account of all gas phase, liquid phase and catalysed reactions performed in microreactors to date.
    • (2002) Tetrahedron , vol.58 , pp. 4735-4757
    • Fletcher, P.D.I.1    Haswell, S.J.2    Pombo-Villar, E.3    Warrington, B.H.4    Watts, P.5    Wong, S.Y.F.6    Zhang, X.7
  • 19
    • 0035127520 scopus 로고    scopus 로고
    • The preparation of a series of nitrostilbene ester compounds using micro reactor technology
    • This paper uses a borosilicate glass microreactor, operating under electrokinetic control, to prepare a range of stilbenes using the Wittig reaction. A range of starting materials are used, demonstrating that it is possible to prepare a combinatorial library of derivatives using the microreactor systems.
    • Skelton V., Greenway G.M., Haswell S.J., Styring P., Morgan D.O., Warrington B., Wong S.Y.F. The preparation of a series of nitrostilbene ester compounds using micro reactor technology. Analyst. 126:2001;7-10 This paper uses a borosilicate glass microreactor, operating under electrokinetic control, to prepare a range of stilbenes using the Wittig reaction. A range of starting materials are used, demonstrating that it is possible to prepare a combinatorial library of derivatives using the microreactor systems.
    • (2001) Analyst , vol.126 , pp. 7-10
    • Skelton, V.1    Greenway, G.M.2    Haswell, S.J.3    Styring, P.4    Morgan, D.O.5    Warrington, B.6    Wong, S.Y.F.7
  • 20
    • 0035129889 scopus 로고    scopus 로고
    • The generation of concentration gradients using electroosmotic flow in micro reactors allowing stereoselective chemical synthesis
    • This paper uses a borosilicate glass microreactor, operating under electrokinetic control, to prepare stilbenes using the Wittig reaction. It discusses how the Z/E ratio of isomers changes depending on the electrokinetic parameters used.
    • Skelton V., Greenway G.M., Haswell S.J., Styring P., Morgan D.O., Warrington B., Wong S.Y.F. The generation of concentration gradients using electroosmotic flow in micro reactors allowing stereoselective chemical synthesis. Analyst. 126:2001;11-13 This paper uses a borosilicate glass microreactor, operating under electrokinetic control, to prepare stilbenes using the Wittig reaction. It discusses how the Z/E ratio of isomers changes depending on the electrokinetic parameters used.
    • (2001) Analyst , vol.126 , pp. 11-13
    • Skelton, V.1    Greenway, G.M.2    Haswell, S.J.3    Styring, P.4    Morgan, D.O.5    Warrington, B.6    Wong, S.Y.F.7
  • 21
    • 0141926734 scopus 로고    scopus 로고
    • The aldol reaction of silyl enol ethers within a micro reactor
    • This paper illustrates how a selection of enolates may be prepared in situ within microreactor devices. The enolates are subsequently reacted with a range of aldehydes to form a variety of aldol products in high yield.
    • Wiles C., Watts P., Haswell S.J., Pombo-Villar E. The aldol reaction of silyl enol ethers within a micro reactor. Lab on a Chip. 1:2001;100-101 This paper illustrates how a selection of enolates may be prepared in situ within microreactor devices. The enolates are subsequently reacted with a range of aldehydes to form a variety of aldol products in high yield.
    • (2001) Lab on a Chip , vol.1 , pp. 100-101
    • Wiles, C.1    Watts, P.2    Haswell, S.J.3    Pombo-Villar, E.4
  • 22
    • 0141955168 scopus 로고    scopus 로고
    • 1,4-Addition of enolates to α,β-unsaturated ketones within a micro reactor
    • This paper prepares a range of Michael adducts by reaction of a selection of diketones with an organic base in a microreactor. The paper illustrates that microreactors may be used to study the kinetics of reactions.
    • Wiles C., Watts P., Haswell S.J., Pombo-Villar E. 1,4-Addition of enolates to α,β-unsaturated ketones within a micro reactor. Lab on a Chip. 2:2002;62-64 This paper prepares a range of Michael adducts by reaction of a selection of diketones with an organic base in a microreactor. The paper illustrates that microreactors may be used to study the kinetics of reactions.
    • (2002) Lab on a Chip , vol.2 , pp. 62-64
    • Wiles, C.1    Watts, P.2    Haswell, S.J.3    Pombo-Villar, E.4
  • 23
    • 0038536135 scopus 로고    scopus 로고
    • Synthesis of a three-member array of cycloadducts in a glass microchip under pressure driven flow
    • This paper demonstrates that an array of compound may be simultaneously produced within microreactor devices operating under pressure-driven flow. This methodology may be used for a combinatorial library of compounds.
    • Garcia-Egido E., Wong S.Y.F., Warrington B.H. Synthesis of a three-member array of cycloadducts in a glass microchip under pressure driven flow. Lab on a Chip. 2:2002;170-174 This paper demonstrates that an array of compound may be simultaneously produced within microreactor devices operating under pressure-driven flow. This methodology may be used for a combinatorial library of compounds.
    • (2002) Lab on a Chip , vol.2 , pp. 170-174
    • Garcia-Egido, E.1    Wong, S.Y.F.2    Warrington, B.H.3
  • 24
    • 0141961502 scopus 로고    scopus 로고
    • A Hantzsch synthesis of 2-aminothiazoles performed in a heated microreactor system
    • This paper reports a convenient method of heating a reaction in a microreactor by aligning a Peltier heating device with the fluidic channels. It is demonstrated how such devices may be applied to combinatorial chemistry.
    • Fernandez-Suarez M., Wong S.Y.F., Warrington B.H. A Hantzsch synthesis of 2-aminothiazoles performed in a heated microreactor system. Lab on a Chip. 2:2002;31-33 This paper reports a convenient method of heating a reaction in a microreactor by aligning a Peltier heating device with the fluidic channels. It is demonstrated how such devices may be applied to combinatorial chemistry.
    • (2002) Lab on a Chip , vol.2 , pp. 31-33
    • Fernandez-Suarez, M.1    Wong, S.Y.F.2    Warrington, B.H.3
  • 26
    • 0036642640 scopus 로고    scopus 로고
    • Solution phase synthesis of β-peptides using micro reactors
    • This paper illustrates that a series of peptide derivatives may be prepared in situ within microreactor devices. The methodology has been extended such that tripeptides may be prepared by careful control of protecting-group chemistry. The paper illustrates that reactions in microreactors are considerably faster than in batch reactions and an electrochemical effect is reported.
    • Watts P., Wiles C., Haswell S.J., Pombo-Villar E. Solution phase synthesis of β-peptides using micro reactors. Tetrahedron. 58:2002;5427-5439 This paper illustrates that a series of peptide derivatives may be prepared in situ within microreactor devices. The methodology has been extended such that tripeptides may be prepared by careful control of protecting-group chemistry. The paper illustrates that reactions in microreactors are considerably faster than in batch reactions and an electrochemical effect is reported.
    • (2002) Tetrahedron , vol.58 , pp. 5427-5439
    • Watts, P.1    Wiles, C.2    Haswell, S.J.3    Pombo-Villar, E.4
  • 27
    • 0038536131 scopus 로고    scopus 로고
    • Investigation of racemisation in peptide synthesis within a micro reactor
    • Watts P., Wiles C., Haswell S.J., Pombo-Villar E. Investigation of racemisation in peptide synthesis within a micro reactor. Lab on a Chip. 2:2002;141-144.
    • (2002) Lab on a Chip , vol.2 , pp. 141-144
    • Watts, P.1    Wiles, C.2    Haswell, S.J.3    Pombo-Villar, E.4
  • 29
    • 0141892179 scopus 로고    scopus 로고
    • Kumada-Corriu reactions in a pressure-driven microflow reactor
    • Haswell S.J., O'Sullivan B., Styring P. Kumada-Corriu reactions in a pressure-driven microflow reactor. Lab on a Chip. 1:2001;164-166.
    • (2001) Lab on a Chip , vol.1 , pp. 164-166
    • Haswell, S.J.1    O'Sullivan, B.2    Styring, P.3
  • 30
    • 0035129890 scopus 로고    scopus 로고
    • Electric field-induced mobilisation of multiphase solution systems based on the nitration of benzene in a micro reactor
    • Doku G.N., Haswell S.J., McCreedy T., Greenway G.M. Electric field-induced mobilisation of multiphase solution systems based on the nitration of benzene in a micro reactor. Analyst. 126:2001;14-20.
    • (2001) Analyst , vol.126 , pp. 14-20
    • Doku, G.N.1    Haswell, S.J.2    McCreedy, T.3    Greenway, G.M.4
  • 31
    • 0141989817 scopus 로고    scopus 로고
    • The investigation of an equilibrium dependent reaction for the formation of enamines in a microchemical system
    • Sands M., Haswell S.J., Kelly S.M., Skelton V., Morgan D.O., Styring P., Warrington B.H. The investigation of an equilibrium dependent reaction for the formation of enamines in a microchemical system. Lab on a Chip. 1:2001;64-65.
    • (2001) Lab on a Chip , vol.1 , pp. 64-65
    • Sands, M.1    Haswell, S.J.2    Kelly, S.M.3    Skelton, V.4    Morgan, D.O.5    Styring, P.6    Warrington, B.H.7
  • 32
    • 0030954703 scopus 로고    scopus 로고
    • Electroosmotic pumping of organic solvents and reagents in microfabricated reactor chips
    • Salimi-Moosavi H., Tang T., Harrison D.J. Electroosmotic pumping of organic solvents and reagents in microfabricated reactor chips. J. Am. Chem. Soc. 119:1997;8716-8717.
    • (1997) J. Am. Chem. Soc. , vol.119 , pp. 8716-8717
    • Salimi-Moosavi, H.1    Tang, T.2    Harrison, D.J.3
  • 33
    • 0037522145 scopus 로고    scopus 로고
    • On-chip generation and reaction of unstable intermediates - monolithic nanoreactors for diazonium chemistry: Azo dyes
    • Wootton R.C.R., Fortt R., de Mello A.J. On-chip generation and reaction of unstable intermediates - monolithic nanoreactors for diazonium chemistry: azo dyes. Lab on a Chip. 2:2002;5-7.
    • (2002) Lab on a Chip , vol.2 , pp. 5-7
    • Wootton, R.C.R.1    Fortt, R.2    De Mello, A.J.3
  • 34
    • 0141989838 scopus 로고    scopus 로고
    • Photocyanation of pyrene across an oil/water interface in a polymer microchannel chip
    • Ueno K., Kitagawa F., Kitamura N. Photocyanation of pyrene across an oil/water interface in a polymer microchannel chip. Lab on a Chip. 2:2002;231-234.
    • (2002) Lab on a Chip , vol.2 , pp. 231-234
    • Ueno, K.1    Kitagawa, F.2    Kitamura, N.3
  • 35
    • 0034616494 scopus 로고    scopus 로고
    • On-chip catalysis using a lithographically fabricated glass microreactor-the dehydration of alcohols using sulfated zirconia
    • Wilson NG, McCreedy T: On-chip catalysis using a lithographically fabricated glass microreactor-the dehydration of alcohols using sulfated zirconia. Chem Commun 2000:733-734.
    • (2000) Chem Commun , pp. 733-734
    • Wilson, N.G.1    McCreedy, T.2
  • 36
    • 0035127470 scopus 로고    scopus 로고
    • Microfabricated reactors for on-chip heterogeneous catalysis
    • McCreedy T., Wilson N.G. Microfabricated reactors for on-chip heterogeneous catalysis. Analyst. 126:2001;21-23.
    • (2001) Analyst , vol.126 , pp. 21-23
    • McCreedy, T.1    Wilson, N.G.2
  • 37
    • 0141886233 scopus 로고    scopus 로고
    • Photochemical reactions and on-line UV detection in microfabricated reactors
    • Lu H., Schmidt M.A., Jenson K.F. Photochemical reactions and on-line UV detection in microfabricated reactors. Lab on a Chip. 1:2001;22-28.
    • (2001) Lab on a Chip , vol.1 , pp. 22-28
    • Lu, H.1    Schmidt, M.A.2    Jenson, K.F.3
  • 38
    • 0036304954 scopus 로고    scopus 로고
    • A microfabricated nanoreactor for safe, continuous generation and use of singlet oxygen
    • Wootton R.C.R., Fortt R., de Mello A.J. A microfabricated nanoreactor for safe, continuous generation and use of singlet oxygen. Organic Process Res. Dev. 6:2002;187-189.
    • (2002) Organic Process Res. Dev. , vol.6 , pp. 187-189
    • Wootton, R.C.R.1    Fortt, R.2    De Mello, A.J.3
  • 39
    • 0035930657 scopus 로고    scopus 로고
    • Fast and high conversion phase-transfer synthesis exploiting the liquid-liquid interface formed in a microchannel chip
    • Hisamoto H, Saito T, Tokeshi M, Hibara A, Kitamori T: Fast and high conversion phase-transfer synthesis exploiting the liquid-liquid interface formed in a microchannel chip. Chem Commun 2001:2662-2663.
    • (2001) Chem Commun , pp. 2662-2663
    • Hisamoto, H.1    Saito, T.2    Tokeshi, M.3    Hibara, A.4    Kitamori, T.5
  • 40
    • 0033591376 scopus 로고    scopus 로고
    • Spink RCH: Microreactors for elemental fluorine
    • Chambers RD: Spink RCH: microreactors for elemental fluorine. Chem Commun 1999:883-884.
    • (1999) Chem Commun , pp. 883-884
    • Chambers, R.D.1
  • 41
    • 0141961176 scopus 로고    scopus 로고
    • Elemental fluorine. Part 13. gas-liquid thin film microreactors for selective direct fluorination
    • Chambers R.D., Holling D., Spink R.C.H., Sandford G. Elemental fluorine. Part 13. gas-liquid thin film microreactors for selective direct fluorination. Lab on a Chip. 1:2001;132-137.
    • (2001) Lab on a Chip , vol.1 , pp. 132-137
    • Chambers, R.D.1    Holling, D.2    Spink, R.C.H.3    Sandford, G.4
  • 43
    • 0002421130 scopus 로고    scopus 로고
    • The formation of cycloalkenes in the partial gas phase hydrogenation of c,t,t 1,5,9-cyclodecatriene, 1,5-cyclooctadiene and benzene in micro channel reactors
    • Edited by Matlosz M, Ehrfeld W, Baselt JP. Berlin: Springer
    • Dietzsch E, Hönicke D, Fichtner M, Schubert K: Weiβmeier G: The formation of cycloalkenes in the partial gas phase hydrogenation of c,t,t 1,5,9-cyclodecatriene, 1,5-cyclooctadiene and benzene in micro channel reactors. In IMRET 4: Proceedings of the Fourth International Conference on Microreaction Technology. Edited by Matlosz M, Ehrfeld W, Baselt JP. Berlin: Springer; 2000:89-93.
    • (2000) IMRET 4: Proceedings of the Fourth International Conference on Microreaction Technology , pp. 89-93
    • Dietzsch, E.1    Hönicke, D.2    Fichtner, M.3    Schubert, K.4    Weißmeier, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.