Rotaxanes of cyclic peptides

Journal of the American Chemical Society

Volumn 128, Issue 6, 2006, Pages 1784-1785

  Aucagne, Vincent ^a   Leigh, David A ^a   Lock, Julia S ^a   Thomson, Andrew R ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; CATION; CYCLOPEPTIDE; MACROCYCLIC COMPOUND; ROTAXANE;

ARTICLE; HYDROGEN BOND; MOLECULAR INTERACTION; PROTEIN FOLDING; PROTEIN STABILITY; STOICHIOMETRY; SYNTHESIS; THERMODYNAMICS;

NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES, CYCLIC; ROTAXANES;

EID: 33244492680     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja057206q     Document Type: Article

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39. To maintain the ammonium template the "stoppering" reaction must be carried out in the absence of base. HCl is generated during the reaction, autocatalyzing ester formation. Since there is the potential for a mixture of counterions in the initially formed rotaxane salts, anion exchange was performed to ensure uniformity.