Synthesis and in vitro evaluation of 18F- and 19F-labeled insulin: A new radiotracer for PET-based molecular imaging studies

Journal of Medicinal Chemistry

Volumn 49, Issue 4, 2006, Pages 1466-1474

  Guenther, Katharina J ^a   Yoganathan, Sabesan ^a   Garofalo, Robert ^b   Kawabata, Thomas ^b   Strack, Thomas ^b   Labiris, Renée ^c   Dolovich, Myrna ^c   Chirakal, Raman ^d   Valliant, John F ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b PFIZER INC   (United States)

^c MCMASTER UNIVERSITY   (Canada)

^d NONE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 FLUOROBENZOIC ACID F 18; 6 AMINOHEXANOYLINSULIN 4 FLUOROBENZOYL F 19; AMINOCAPROIC ACID; DEOXYGLUCOSE; HUMAN INSULIN; INSULIN; INSULIN F 18; INSULIN F 19; INSULIN RECEPTOR; SUCCINIMIDYL 4 FLUOROBENZOATE F 18; TRACER; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CHO CELL; CONTROLLED STUDY; DRUG CONJUGATION; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; EMBRYO; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MASS SPECTROMETRY; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTEIN PHOSPHORYLATION; RADIOACTIVITY; RADIOCHEMISTRY; STATISTICAL SIGNIFICANCE; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY;

ADIPOCYTES; ANIMALS; CELLS, CULTURED; CRICETINAE; CRICETULUS; DEOXYGLUCOSE; FLUORINE RADIOISOTOPES; HUMANS; INSULIN; ISOTOPE LABELING; PHOSPHORYLATION; POSITRON-EMISSION TOMOGRAPHY; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; RECEPTOR, INSULIN; RECOMBINANT PROTEINS;

EID: 33244487460     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0509344     Document Type: Article

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