Optimization of 2,4-diaminopyrimidines as GHS-R antagonists: Side chain exploration

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 7, 2006, Pages 1864-1868

  Liu, Bo ^a   Liu, Mei ^a   Xin, Zhili ^a   Zhao, Hongyu ^a   Serby, Michael D ^a   Kosogof, Christi ^a   Nelson, Lissa T J ^a   Szczepankiewicz, Bruce G ^a   Kaszubska, Wiweka ^a   Schaefer, Verlyn G ^a   Falls, H Douglas ^a   Lin, Chun Wel ^a   Collins, Christine A ^a   Sham, Hing L ^a   Liu, Gang ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

DHFR selectivity; Diaminopyrimidine; Ghrelin; GHS R antagonist

Indexed keywords

2,4 DIAMINOPYRIMIDINE DERIVATIVE; CHOLESTEROL; DIHYDROFOLATE REDUCTASE; GROWTH HORMONE SECRETAGOGUE RECEPTOR ANTAGONIST; HORMONE RECEPTOR BLOCKING AGENT; ISOXAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHOLESTEROL SIDE CHAIN CLEAVAGE; DRUG ANTAGONISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

PYRIMIDINES; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 33144468937     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.01.012     Document Type: Article

References (14)

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