Potent 4-arylalkyl-substituted 3-isothiazolol GABAA competitive/noncompetitive antagonists: Synthesis and pharmacology

Journal of Medicinal Chemistry

Volumn 49, Issue 4, 2006, Pages 1388-1396

  Krehan, Dorte ^a   Storustovu, Signe Í ^b   Liljefors, Tommy ^a   Ebert, Bjarke ^b   Nielsen, Birgitte ^a   Krogsgaard Larsen, Povl ^a   Frølund, Bente ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2 NAPHTHYLMETHYL) 5 (4 PIPERIDYL)ISOTHIAZOL 3 OL; 4 (2,2 DIPHENYL 1 ETHYL) 5 (4 PIPERIDYL)ISOTHIAZOL 3 OL; 4 (3,3 DIPHENYL 1 PROPYL) 5 (4 PIPERIDYL)ISOTHIAZOL 3 OL; 4 [(1 BROMO 2 NAPHTHYL)METHYL] 5 (4 PIPERIDYL)ISOTHIAZOL 3 OL; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 BENZYL 5 (4 PIPERIDYL)ISOTHIAZOL 3 OL; 4 METHYL 5 (4 PIPERIDYL)ISOTHIAZOL 3 OL; 5 (4 PIPERIDYL) 3 ISOXAZOLOL; 5 (4 PIPERIDYL) 4 PROPYLISOTHIAZOL 3 OL; ALKYL GROUP; GABOXADOL; ISOTHIAZOLE DERIVATIVE; LIGAND; MUSCIMOL; NAPHTHALENE DERIVATIVE; PARTIAL AGONIST; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; THIO 5 (4 PIPERIDYL) 3 ISOXAZOLOL; THIOGABOXADOL; THIOMUSCIMOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; FEMALE; MODEL; MOLECULAR RECOGNITION; NONHUMAN; OOCYTE; STEREOCHEMISTRY; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; VOLTAGE CLAMP; XENOPUS LAEVIS;

ANIMALS; BENZENE DERIVATIVES; BRAIN; FEMALE; HUMANS; LIGANDS; MODELS, MOLECULAR; NAPHTHALENES; OOCYTES; PATCH-CLAMP TECHNIQUES; RADIOLIGAND ASSAY; RATS; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; XENOPUS LAEVIS;

EID: 33144465898     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050987l     Document Type: Article

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